6 results match your criteria: "National Institute of Infectious Diseases Lazzaro Spallanzani IRCCS[Affiliation]"
Subsequent Waves of Convergent Evolution in SARS-CoV-2 Genes and Proteins.
Vaccines (Basel)
August 2024
Laboratory of Virology and Laboratory of Biosecurity, National Institute of Infectious Diseases Lazzaro Spallanzani-IRCCS, 00149 Rome, Italy.
Beginning in 2022, following widespread infection and vaccination among the global population, the SARS-CoV-2 virus mainly evolved to evade immunity derived from vaccines and past infections. This review covers the convergent evolution of structural, nonstructural, and accessory proteins in SARS-CoV-2, with a specific look at common mutations found in long-lasting infections that hint at the virus potentially reverting to an enteric sarbecovirus type.
View Article and Find Full Text PDFImpact of COVID-19 pandemic on retention in care of native and migrant people with HIV in the ICONA cohort.
Travel Med Infect Dis
March 2024
Clinical and Research Infectious Diseases Department, National Institute of Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Article Synopsis
- The COVID-19 pandemic impacted HIV care, particularly affecting the retention in care of migrant people with HIV (PWH), prompting research into these disparities.
- A study compared HIV retention before and during the pandemic, revealing that temporary loss to follow-up (LTFU) was significantly higher among migrant PWH (19.6%) compared to native PWH (10.5%) during the pandemic.
- The data showed persistent issues, as LTFU for migrant PWH remained elevated across both periods, highlighting the need for targeted interventions to support these individuals and improve their retention in care.
Long-term outcome of dolutegravir-containing regimens according to sex: data from the ICONA study.
J Antimicrob Chemother
April 2023
Centre for Clinical Research, Epidemiology, Modelling and Evaluation (CREME), Institute for Global Health, University College London, London, UK.
Objectives: To compare the long-term risk of treatment failure of dolutegravir-based ART in men and women in a real-life setting.
Patients And Methods: Persons living with HIV (PLWH) from the ICONA cohort were included if they had started dolutegravir in a two- or three-drug regimen as ART-naive or as virologically controlled ART-experienced. The primary endpoint was time to treatment failure (virological/clinical failure or dolutegravir discontinuation).
Cutaneous Endothelial Dysfunction and Complement Deposition in COVID-19.
Am J Dermatopathol
March 2021
Dermatology Unit, National Institute of Infectious Diseases Lazzaro Spallanzani-IRCCS, Rome, Italy.
Central Nervous System involvement in tuberculosis: An MRI study considering differences between patients with and without Human Immunodeficiency Virus 1 infection.
J Neuroradiol
September 2020
NESMOS Department University of Rome Sapienza. Azienda Ospedaliero-Universitaria Sant'Andrea, Roma, Italy.
Background: Magnetic resonance imaging (MRI) is largely used in the diagnosis of central nervous system involvement of tuberculosis (CNSTB), yet there is no MRI comparison study between HIV+ and HIV- patients with CNSTB. The aim of the present study was to identify MRI differences in CNSTB between HIV+ and HIV- patients and possibly find early characteristics that could raise the suspect of this disease.
Methods: We included all patients admitted in our institution between 2011 and 2018 with confirmed diagnosis of CNSTB, and MRI performed in the first week.
Acute human immunodeficiency virus replication causes a rapid and persistent impairment of Vgamma9Vdelta2 T cells in chronically infected patients undergoing structured treatment interruption.
J Infect Dis
September 2002
National Institute of Infectious Diseases "Lazzaro Spallanzani" IRCCS, Rome, Italy.
Article Synopsis
- * Chronic HIV infection alters the composition and function of these T cells, but this can be reversed with highly active antiretroviral therapy (HAART).
- * In patients undergoing treatment interruption, a decrease in Vgamma9Vdelta2 T cells correlates with increased HIV replication, leading to reduced immune response, which is restored once HAART is resumed.