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2 results match your criteria: "National Institute of Environmental Health Sciences of National Institutes of Health[Affiliation]"
Front Genet
June 2020
Biomolecular Screening Branch, National Institute of Environmental Health Sciences of National Institutes of Health, Durham, NC, United States.
Analysis of bulk RNA sequencing (RNA-Seq) data is a valuable tool to understand transcription at the genome scale. Targeted sequencing of RNA has emerged as a practical means of assessing the majority of the transcriptomic space with less reliance on large resources for consumables and bioinformatics. TempO-Seq is a templated, multiplexed RNA-Seq platform that interrogates a panel of sentinel genes representative of genome-wide transcription.
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June 2019
*Biomolecular Screening Branch, Division of National Toxicology Program, National Institute of Environmental Health Sciences of National Institutes of Health, Durham, North Carolina 27709.
Prediction of human response to chemical exposures is a major challenge in both pharmaceutical and toxicological research. Transcriptomics has been a powerful tool to explore chemical-biological interactions, however, limited throughput, high-costs, and complexity of transcriptomic interpretations have yielded numerous studies lacking sufficient experimental context for predictive application. To address these challenges, we have utilized a novel high-throughput transcriptomics (HTT) platform, TempO-Seq, to apply the interpretive power of concentration-response modeling with exposures to 24 reference compounds in both differentiated and non-differentiated human HepaRG cell cultures.
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