Effect of soluble factors derived from ZR 75.30 breast cancer cells on endothelial activation.

In this study, we analyzed soluble factors secreted by two Estrogen Receptor Positive (ER-α) human breast cancer cell lines, ZR 75.30 (luminal B) and MCF7 (luminal A), and evaluated their effect on endothelial activation. The composition of tumoral soluble factors (TSFs) was analyzed by ELISA (Bio-Plex).

Premature and severe cardiovascular disease in a Mexican male with markedly low high-density-lipoprotein-cholesterol levels and a mutation in the lecithin:cholesterol acyltransferase gene: a family study.

Epidemiological and clinical studies have shown that a low plasma high‑density lipoprotein cholesterol (HDL-C) level is a strong predictor of cardiovascular disease (CVD). Lecithin:cholesterol acyltransferase (LCAT) is a key enzyme in the formation, maturation and function of HDL. Therefore impaired LCAT function may enhance atherosclerosis because of defective cholesterol transport.

[Echocardiography in infirmary].

Cardiovascular diseases are the 1st death cause worldwide in the beginning of the third millennium. Due to its high incidence and fatal complications the study of ischaemic cardiopathy had great importance. Echocardiography is an image diagnostic technique, based on the use of ultrasound, applied in the evaluation and recognition of cardiovascular diseases.

[Patient selection for catheter ablation of atrial fibrillation].

The present report describes the program of radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF) in patients referred to the AF Clinic of the National Institute of Cardiology. Specific inclusion criteria are required for RFCA of AF. If the patient fulfills it, then an electrophysiological study is performed.

[Sugical treatment of aortic coarctation. Long-term results at National Institute of Cardiology of Mexico].

Objectives: Evaluate long-term evolution of patients submitted to surgery for coarctation of the aorta. Compare event free survival in younger vs older patients at the time of surgical correction.

Methods: We reviewed the clinical records of patients operated for coarctation of the aorta from January 1 1980 to December 31 1994.

[Rheumatic heart disease: cause of cerebrovascular disease at the National Institute of Cardiology "Ignacio Chávez"].

Objective: To review the epidemiological profile of stroke associated to rheumatic heart disease (RHD) in a Mexican Cardiovascular Center. Cardioembolic stroke is one of the most severe causes of death and disability and the spectrum of its neurological complications is diverse.

Patients And Methods: This is a 10-years retrospective study of 709 patients with stroke diagnosis from the National Institute of Cardiology "Ignacio Chávez" Stroke Data Bank from 1991 to 2000.

[Surgical treatment results of congenital heart defects in children with Down's syndrome].

We made a retrospective study of patients with Down's syndrome that were surgically treated for correction or palliation for their congenital heart disease between january 1996 to december of the 2000 in the National Institute of Cardiology "Ignacio Chávez". We analyzed these variables: age at the surgical moment, sex, congenital heart defect, pulmonary arterial pressure, type of surgery, time of stay in the intensive care unit, complications and mortality. In this period they were surgically treated 37 patients.

17 beta-estradiol modulates effects of insulin-induced changes in vascular contractility.

The protective role of estrogens against peripheral vascular and coronary disease in women is well documented; however, it is not present in diabetic women. Estrogens reduce tension development through non-genomic mechanisms that include changes in calcium concentrations in endothelial and smooth muscle cells, and regulation of nitric oxide synthase (NOS) in endothelial cells. Insulin increases endothelin-1 (ET-1) release from endothelial cells modulating smooth muscle calcium levels and elevating force generated by femoral and coronary arteries.

[New generation of bioprosthesis of the "Ignacio Chávez" National Institute of Cardiology].

The INC has been a pioneer in producing cardiac bioprostheses in Mexico. Since the 1970's it has produced and implanted more than 2,500 bioprostheses, first made of duramater and later on, made of cattle pericardium. Nowadays, it is working on the production of a new generation of bioprostheses of cattle pericardium as well as of pigs with or without support; to these, a system to reduce calcification has been added, as a result of research being performed at the Applied Biotechnics Department.

[Nursing process in advanced cardiopulmonary resuscitation].

The process male nurse is a systematic and organized method to offer effective and efficient cares guided to the achievement of solving real problems of health, reducing the incidence and the duration. It is organized and systematic for that consists of five sequential and interrelated steps: Valuation, diagnostic, planning, execution and evaluation, in which are carried out interrelated actions, thought to maximize the long term results. The nurse process is based on the notion that the success of the cares is measured by the degree of effectiveness and the degree of satisfaction and the patient's progress.

[Kidney transplantation].

The first renal transplant with little success was performed in 1933. It was not until 1947, in Boston (USA), when a cadaveric kidney was transplanted into a female patient with septic shock, renewing natural diuresis in two months. In 1950, different European and American medical teams had already proceeded with renal transplants in humans from cadaver donors with positive results, followed by an absolute success with the first renal transplant in univitelline twins in 1954.

[Treatment of systemic arterial hypertension].

The World Health Organization (WHO) and several other international committees on the study of hypertension define that a patient with blood pressure between 140/90-150/95 mmHg must be treated. In the first stage of hypertension it is possible to modify it with life style changes, but if high blood pressure persists, then drug therapy must be evaluated carefully. Drug therapy management is individualized and based upon age, race, previous history of hypertension, and risks for target systemic organs.

[Specific dilated myocardiopathy. Chronic chagasic cardiopathy at the National Institute of Cardiology Ignacio Chávez].

Cardiomyopathies are a heterogenous group of heart ailments. Some of them are primary myocardial diseases and are classified as dilated, hypertrophic, restrictive and arryhithmogenic. Dilated cardiomyopathies (DCs) are the most common.

[Fast pathway for heart surgery].

The increasing demographic and life expectancy rates, together with the vertiginous technological development during the last two decades, have raised the number of cardiac patients requiring surgical treatment. Therefore, several institutions have been forced to give priority to advanced or more serious cases and to postpone those that do not demand an urgent surgery. This analysis was made from June 15, 1999 to June 15, 2000 and demonstrates the results obtained from maintaining a fast track at the National Institute of Cardiology "Ignacio Chávez".

[Application of pharmacologic treatment in acute myocardial infarction].

Pharmacological therapeutics in acute myocardial infarction. The acute myocardial infarct is one of the main causes of death among the adult population of the industrialized countries, and this pattern is starting to be paralleled in many developing countries. The mortality rate due to coronary diseases has decreased 30% in the last decade, thanks to the new therapeutic strategies and the guidelines developed by the American college of Cardiology and the American Heart Association, aimed at physicians, nurses, and health personnel in charge of patients with suspected myocardial infarct or with an established myocardial infarct.

[One-and-a-half correction. Results at the National Institute of Cardiology "Ignacio Chávez"].

Herein we describe a preliminary report of 4 patients with hypoplastic right ventricle and 3 patients with Ebstein's anomaly who undergone "one and a half" repair at the Instituto Nacional de Cardiología "Ignacio Chávez". There was not surgical mortality and at mid-term follow up the patients are doing well.

[Fontan surgery in tricuspid atresia. Experience at the National Institute of Cardiology "Ignacio Chávez"].

A retrospective analysis is presented of all patients under 18 years of age with tricuspid atresia and concordant ventriculo-arterial connection who underwent a Fontan procedure in the National Cardiology Institute "Ignacio Chávez", México-City, between January 1989 and December 1995. In this period Fontan procedure was performed in 22 patients with a mean age of 6.52 +/- 1.

[Bidirectional cavopulmonary diversion for tricuspid atresia. Experience in the National Institute of Cardiology].

Bidirectional cavopulmonary shunt is an alternative palliative procedure for patients with congenital cyanotic heart disease, specially those patients less than "ideal" candidates for a Fontan's procedure. We present our results with this shunt in patients with tricuspid atresia. Twenty patients with tricuspid atresia were operated on with this shunt, with these associated defects: 20 atrial septal defect, 17 ventricular septal defect, 10 pulmonary stenosis, 1 pulmonary atresia and 1 transposition of the great arteries.

[The primary outcome in transluminal coronary angioplasty: the recent experience of the Instituto Nacional de Cardiología (1991-1992)].

Percutaneous balloon coronary angioplasty had a slow start in Mexico, and until recently only a relatively small number of procedures have been performed. Since March 1991, the Instituto Nacional de Cardiología has state-of-the-art fluoroscopic imaging and easy access to a variety of balloon coronary angioplasty catheters and accessories. Under these conditions, an increasing number of PTCAs have been performed (221 procedures in an initial 15 month period).