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Article Synopsis
  • The COVID-19 pandemic has posed significant challenges to global healthcare, prompting a search for better treatment options alongside existing FDA-approved therapies.
  • The clinical management of COVID-19 involves infection prevention and supportive care, such as oxygen therapy and mechanical ventilation, while emergency protocols have been established to expedite patient access to potential treatments.
  • This manuscript explores the potential of using short-interfering RNA (siRNA) for targeting and degrading the SARS-CoV-2 genome, highlighting delivery methods using FDA-approved nanoparticulate systems that could be formulated as inhalable aerosols.
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