The COVID-19 pandemic has posed significant challenges to global healthcare, prompting a search for better treatment options alongside existing FDA-approved therapies.
The clinical management of COVID-19 involves infection prevention and supportive care, such as oxygen therapy and mechanical ventilation, while emergency protocols have been established to expedite patient access to potential treatments.
This manuscript explores the potential of using short-interfering RNA (siRNA) for targeting and degrading the SARS-CoV-2 genome, highlighting delivery methods using FDA-approved nanoparticulate systems that could be formulated as inhalable aerosols.