226 results match your criteria: "National Hospital Organization Yokohama Medical Center.[Affiliation]"

Patients with an unruptured ovarian pregnancy may exhibit signs of shock. Laparoscopy is well-suited for the detection of ovarian pregnancy. Viable pregnancies are possible for patients with ovarian pregnancy and a low risk of ectopic pregnancy.

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Objectives: New scores were developed to identify at-risk metabolic dysfunction-associated steatohepatitis (MASH) using multiparametric MRI (mpMRI).

Materials And Methods: A prospective study was conducted on 176 patients with suspected or diagnosed metabolic dysfunction-associated steatotic liver disease (MASLD) paired with an MR scan, vibration-controlled transient elastography (VCTE), and liver biopsy. Liver stiffness measurement (LSM) using magnetic resonance elastography (MRE), proton density fat fraction (PDFF), and mpMRI-based corrected T1 (cT1) were combined to develop a one-step strategy, named MPcT (MRE + PDFF + cT1, combined score), and a two-step strategy-MRE-based LSM followed by PDFF with cT1 (M-PcT, paired score) for diagnosing at-risk MASH.

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Aim: Gastric cancer is one of the leading causes of cancer-related mortalities worldwide. According to the pathological TNM classification, T3N0M0, Stage IIA gastric cancer has been excluded from the S-1 adjuvant chemotherapy trials. Thus, the clinical impact of S-1 adjuvant chemotherapy in patients with pathological T3N0M0 cancer and the associated prognostic factors have not been elucidated.

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  • A 40-year-old Japanese man with HIV experienced a decline in consciousness after two years of not receiving treatment, showing severe weight loss and a critically low CD4+ lymphocyte count.
  • He was diagnosed with disseminated Mycobacterium avium infection and pneumocystis pneumonia, and a brain biopsy confirmed varicella zoster virus (VZV) encephalitis.
  • The patient was treated with antiretroviral therapy and intravenous acyclovir, leading to survival but with ongoing neurological complications; VZV encephalitis is rare and carries a poor prognosis in AIDS patients.
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Background: Various surgical procedures have employed microporous polysaccharide hemosphere (MPH) hemostatic agents. However, data regarding their effectiveness in preventing pocket hematomas (PHs) during the implantation of cardiac implantable electronic devices (CIED) among the Asian population are limited. Therefore, this study aimed to investigate the potential benefits of using MPH hemostatic agents during CIED implantations as a preventive measure against post-procedural PHs.

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Superficial abdominal surgical site infection caused by Aspergillus welwitschiae: a case report.

BMC Infect Dis

September 2024

Department of Critical Care and Emergency Medicine, National Hospital Organization Yokohama Medical Center, 3-60-2 Harajuku, Totsuka-Ward, Yokohama City, Kanagawa, 245-8575, Japan.

Background: Aspergillus spp. are rare causes of surgical site infections (SSIs). Specifically, Aspergillus section Nigri, commonly identified as Aspergillus niger through morphological findings, has infrequently been reported as an abdominal SSI pathogen.

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  • - Primary squamous cell carcinoma of the kidney is rare, with limited cases documented in medical literature.
  • - A 73-year-old man was diagnosed with this rare tumor after imaging showed a mass in his kidney extending to the liver, leading to a radical nephrectomy and partial liver surgery.
  • - Despite surgery, the patient experienced rapid disease progression, with recurrences and lung metastases, highlighting the need for quick intervention when such cancers are suspected.
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Introduction: Even after the peak of the COVID-19 pandemic, the number of mild cases remains high, requiring continuous control. Curcumin, owing to its anti-inflammatory properties, can suppress vital proliferation and cytokine secretion in animal models. We developed a highly absorbable curcumin, curcuRouge (cR), which is approximately 100 times more orally bioavailable than conventional curcumin.

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  • The study focused on very elderly patients (aged 80 and above) with acute coronary syndrome (ACS) who underwent percutaneous coronary intervention (PCI), investigating their clinical outcomes over one year.
  • It included 1337 patients divided into four age groups, with findings showing that the very elderly had a higher rate of all-cause death compared to the sexagenarian group.
  • After accounting for various patient factors, there were no significant differences in the overall outcomes between the very elderly and sexagenarian groups, suggesting comparable results when adjusting for health conditions and characteristics.
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  • * A 74-year-old Japanese woman with a long history of sinus issues and asthma developed AERD after an adverse reaction to NSAIDs, leading to a diagnosis of severe eosinophilic CRSwNP.
  • * Switching her treatment from benralizumab to tezepelumab resulted in significant improvements in her asthma symptoms, nasal congestion, and olfactory dysfunction, indicating the importance of tailored therapies for CRSwNP and AERD.
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  • The study explores how the COVID-19 pandemic affected the prevalence of respiratory infections and asthma in young children.
  • It compares data from infants born during the pandemic in Japan to those born before it, focusing on asthma incidents at 18 months and 3 years of age.
  • Results suggest that pandemic conditions, which limited viral infections, may have led to a lower incidence of asthma in children under 18 months, highlighting the need for infection prevention in early infancy.
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  • Monosodium glutamate (MSG) is a common food additive known for enhancing flavor, especially in Asian dishes.
  • A case report discusses a 21-year-old woman who experienced tongue swelling after consuming snacks, leading to the discovery of a weak allergic reaction to MSG through skin tests.
  • An oral challenge test confirmed her allergy with pathology findings showing swelling and mast cell infiltration, marking it as the first documented case of a type 1 allergy to MSG.
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  • The study focuses on the issue of high recurrence rates of colorectal cancer liver metastasis (CRCLM) after surgery, assessing the effectiveness of adjuvant chemotherapy using S-1 and oxaliplatin (SOX).
  • Conducted as a multicenter, randomized phase II trial, the research compares low and high doses of oxaliplatin in patients who have undergone curative resection of CRCLM, monitoring toxicity and relapse-free survival.
  • Results indicated that both dose groups had similar rates of treatment discontinuation due to toxicity (around 60% in low-dose vs. 53.8% in high-dose), with common adverse events being neutropenia, diarrhea, and neuropathy, and a 3
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Unlabelled: Insertable cardiac monitors (ICMs) are small electrocardiographs implanted subcutaneously to automatically record electrocardiograms when arrhythmia is detected in patients with syncope. If the ICM misses a significant arrhythmia, it may delay the diagnosis of arrhythmogenic syncope and put the patient at risk. Herein, we describe a case of undetected cardiac arrest in a patient with ICM.

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Introduction: The number of facilities adopting intracorporeal urinary diversion (ICUD) using robots instead of extracorporeal urinary diversion (ECUD) is increasing. However, guidance on how to introduce robot-assisted radical cystectomy (RARC) + ICUD in each urological institute remains unclear. This study aimed to verify the feasibility of the transition from laparoscopic radical cystectomy (LRC) + ECUD to RARC + ICUD.

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  • - Ultrasound-guided central venous catheterization (CVC) has various approaches, but this study focused on comparing first-attempt success rates and arterial puncture rates of five methods: internal jugular, supraclavicular subclavian, infraclavicular subclavian, proximal axillary, and distal axillary veins.
  • - The review included 13 randomized controlled trials with over 4,400 participants, showing that the supraclavicular subclavian approach likely offers the highest first-attempt success rate compared to the other methods, particularly over the internal jugular vein.
  • - Although the supraclavicular approach is preferred due to higher success rates, arterial puncture rates were relatively consistent across all methods,
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Identification of differentially methylated regions associated with both liver fibrosis and hepatocellular carcinoma.

BMC Gastroenterol

February 2024

Laboratoy of Pathophysiology and Pharmacotherapeutics, Faculty of Pharmacy, Osaka Ohtani University, 3-11-1 Nishikiori-kita, Tondabayashi, Osaka, 584-8540, Japan.

Background: Liver fibrosis is a major risk factor for hepatocellular carcinoma (HCC). We have previously reported that differentially methylated regions (DMRs) are correlated with the fibrosis stages of metabolic dysfunction-associated steatotic liver disease (MASLD). In this study, the methylation levels of those DMRs in liver fibrosis and subsequent HCC were examined.

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Treating ocular involvement in eosinophilic granulomatosis with polyangiitis (EGPA) can be challenging. We present the case of a 37-year-old woman with EGPA who had severe bilateral visual field defects. Laboratory results showed leukocytosis (17,500 WBC/μL, 25.

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Introduction: Isolated fallopian tube torsion (IFTT) has rarely been confirmed in sexually inactive adolescents, and preoperative diagnosis of IFTT is difficult because of the absence of specific symptoms. Therefore, pediatric patients with IFTT tend to be misdiagnosed before the surgery.

Case: A 15-year-old female patient with no history of abdominal surgery or sexual intercourse presented with acute left lower abdominal pain and purpura.

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  • Lung sound analysis was tested as a way to predict recurrent wheezing (RW) in healthy children, which can be an early sign of asthma.
  • In a study involving 62 children aged 3 to 24 months, 30.6% developed RW by age 3, with specific lung sound parameters being lower in this group.
  • The findings suggest that lung sound analysis might provide noninvasive insights for high-risk groups, particularly those with atopic dermatitis or elevated IgE levels, to identify potential asthma development.
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  • Istradefylline (IST) is investigated as an adjunctive treatment for Parkinson's disease (PD) to see if it can reduce the need for higher doses of levodopa, which is commonly linked to motor complications.
  • In a study with 114 PD patients experiencing wearing-off symptoms, those receiving IST required significantly less additional levodopa over 37 weeks compared to those who did not receive IST.
  • Patients treated with IST also showed improvements in motor functions measured by rating scales and wearable devices, suggesting that IST may enhance symptom management without increasing levodopa dosage significantly.
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  • Dupilumab blocks the IL-4/IL-13 pathway, leading to increased eosinophils in the blood, which can potentially contribute to chronic eosinophilic pneumonia (CEP) but no direct link has been established.
  • A 33-year-old woman with a history of asthma and previous CEP experienced multiple asthma exacerbations and a recurrence of CEP despite steroid treatment.
  • After starting dupilumab, her asthma symptoms improved significantly, and she didn't experience any further asthma exacerbations or CEP relapses over a 12-month period, suggesting it may be an effective option for similar patients.
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Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD), is the most common liver disease. It has a rapidly growing patient population owing to the increasing prevalence of obesity and type 2 diabetes. Patients with MASLD are primarily treated by family physicians when fibrosis is absent or mild and by gastroenterologists/hepatologists when fibrosis is more advanced.

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