528 results match your criteria: "National Hospital Organization Okayama Medical Center.[Affiliation]"

Background: Pulmonary arterial hypertension (PAH) is a rare, progressive disease. The treatment landscape for PAH in Japan has evolved considerably in recent years, but there is limited knowledge of the changes in treatment practices or patient characteristics.

Objectives: The aim of this study was to evaluate the changes in characteristics and initial treatments for PAH in Japan over time.

View Article and Find Full Text PDF

Background: Although previous studies have demonstrated that paediatric pulmonary arterial hypertension remains distinct from that in adults, there are limited studies evaluating a direct comparison between children and adults. The aim of this head-to-head comparison study was to compare the gender, haemodynamic parameters, and prognosis between paediatric and adult pulmonary arterial hypertension.

Methods And Results: We retrospectively assessed the clinical differences in 40 childhood-onset (under 20 years old) patients and 40 adult-onset patients with idiopathic and heritable pulmonary arterial hypertension who were followed up at two centres.

View Article and Find Full Text PDF

Leptomeningeal metastasis (LM) is a rare but devastating cancer complication. LM occurs when cancer spreads into the leptomeningeal layer or cerebrospinal fluid. Intracranial magnetic resonance (MR) images of LM are characterized by the diffuse enhancement of the leptomeninges along the cerebral sulci, cerebellar folia, and cranial nerves.

View Article and Find Full Text PDF

More than one-third of advanced non-small-cell lung cancer patients do not receive immunochemotherapy due to intolerance.

J Cancer Res Clin Oncol

July 2023

Department of Allergy and Respiratory Medicine, Okayama University Hospital, 2-5-1 Shikata-Cho Kita-Ku Okayama City, Okayama, 700-8558, Japan.

Article Synopsis
  • Combination therapy of immune checkpoint inhibitors (ICIs) with chemotherapy is the standard treatment for advanced non-small-cell lung cancer (NSCLC) but may have higher toxicity compared to monotherapy, affecting its usage.
  • In a cohort study analyzing 919 advanced NSCLC patients, approximately 48% received ICI + chemotherapy, while 71% of those not receiving it cited intolerance as the main reason.
  • The findings highlight that a significant number of patients are unable to benefit from the combination therapy due to intolerance, raising concerns about its practical implementation in clinical settings.
View Article and Find Full Text PDF

Introduction: Pembrolizumab is a programmed death-ligand 1 inhibitor that was initially indicated for monotherapy in patients with advanced lung cancer. The Japanese Lung Cancer Society conducted an observational study on pembrolizumab using confirmative data obtained through postmarketing all-case surveillance (PMACS), which was performed by a pharmaceutical company under the Japanese law in 2017.

Methods: This multicenter observational study was conducted by the Japanese Lung Cancer Society using PMACS data with the newly created central registration system regarding patients with NSCLC who received pembrolizumab monotherapy between February 1, 2017 and June 30, 2017; a new database was created by adding the clinical information regarding prognosis for 3 years after therapy to the existing data collected by PMACS.

View Article and Find Full Text PDF

Objective: Postoperative atrial fibrillation (POAF) after cardiac surgery is associated with increased mortality. The efficacy of landiolol hydrochloride for POAF prevention after coronary artery bypass grafting procedure and valve surgery has been reported. However, little evidence is available on its role in POAF prevention after aortic root, ascending aorta, and aortic arch surgery.

View Article and Find Full Text PDF

A 91-year-old man was on his seventh course of pembrolizumab for recurrence of right renal pelvic cancer. On the 8th day of treatment, he was admitted to the hospital with idiopathic fever and malaise. On the 12th day, the patient experienced tonic convulsions and exhibited an impaired consciousness.

View Article and Find Full Text PDF

Background: Varicella-zoster virus (VZV) reactivation is a serious complication of hematopoietic stem cell transplantation (HSCT). Although low-dose acyclovir can prevent VZV reactivation after HSCT in adults, the efficacy of a dose of acyclovir lower than the recommended dose, such as 60-80 mg/kg/day in children, is unclear. In this study, we aimed to evaluate the incidence of VZV reactivation after HSCT during and after low-dose acyclovir administration for preventing VZV reactivation in children.

View Article and Find Full Text PDF

Introduction: Extramammary myofibroblastomas are extremely rare.

Case Presentation: The patient was an 88-year-old male. He presented for evaluation of frequent urination and a "pushing up" sensation from the groin during defecation.

View Article and Find Full Text PDF

Autologous stem cell transplantation (ASCT) remains an important therapeutic strategy for multiple myeloma; however, a proportion of patients fail to mobilize a sufficient number of peripheral blood stem cells (PBSCs) to proceed to ASCT. In the present study, we aimed to clarify the characteristics and outcomes of poor mobilizers. Clinical data on poorly mobilized patients who underwent PBSC harvest for almost 10 years were retrospectively collected from 44 institutions in the Japanese Society of Myeloma (JSM).

View Article and Find Full Text PDF

A 73-year-old woman in complete remission from localized small-cell lung cancer associated with Lambert-Eaton myasthenic syndrome (LEMS) 22 years earlier was referred to our hospital and diagnosed with non-small-cell lung cancer. After three courses of pembrolizumab, an immune checkpoint inhibitor, the patient complained of muscle weakness, fatigue, ptosis, and dysarthria. The anti-voltage-gated calcium channel antibody level was elevated, and waxing was observed on a high-frequency repetitive stimulation test using an electromyogram.

View Article and Find Full Text PDF

Failed internal fixations for trochanteric fractures have a strong negative impact owing to increased postoperative mortality and high medical costs. However, evidence on the prognostic value of postoperative radiographic findings for failed internal fixations is limited. We aimed to clarify the association between comprehensive immediate postoperative radiographic findings and failed internal fixation using relative and absolute risk measures.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the effectiveness and safety of durvalumab following chemoradiotherapy (CRT) using cisplatin and S-1 in patients with unresectable locally advanced non-small cell lung cancer (LA-NSCLC), a combination not previously evaluated prospectively.
  • Out of 59 patients treated, 86.4% successfully transitioned to durvalumab, with the most common reasons for not proceeding being disease progression and adverse events, though most issues were manageable.
  • The results show promising outcomes with a 62.7% objective response rate and high disease control rate, alongside low incidences of severe side effects like pneumonitis.
View Article and Find Full Text PDF

Background: To explore the predictive value of the Thompson score during the first 4 days of life for estimating short-term adverse outcomes in neonatal encephalopathy.

Methods: This observational study evaluated infants with neonatal encephalopathy (≥36 weeks of gestation) registered in a multicenter cohort of cooled infants in Japan. The Thompson score was evaluated at 0-24, 24-48, 48-72, and 72-90 h of age.

View Article and Find Full Text PDF

Coffin-Siris syndrome (CSS) is a congenital disorder that is characterized by an absent/hypoplastic fifth distal phalanx, psychomotor developmental delay, and coarse facial features. One of the causative genes, ARID1B (AT-rich interactive domain-containing protein 1B), encodes components of the BAF chromatin remodeling complexes. Here, we report a case of a 3-year 8-month-old male with a novel nonsense variant (NM_001374820.

View Article and Find Full Text PDF

Background: The purpose of this study was to clarify the clinical features of ossification of the posterior longitudinal ligament (OPLL) and extreme ossification at multiple sites.

Methods: This prospective study involved patients with a diagnosis of cervical OPLL at 16 institutions in Japan. Patient-reported outcome measures, including responses on the Japanese Orthopaedic Association (JOA) Cervical Myelopathy Evaluation Questionnaire (JOA-CMEQ), JOA Back Pain Evaluation Questionnaire (JOA-BPEQ), and visual analog scale pain score, were collected to investigate clinical status.

View Article and Find Full Text PDF

Purpose: This phase I/II clinical study was conducted to examine the safety, tolerability, pharmacokinetics, and efficacy of 10-min dosing of bendamustine in patients with previously untreated indolent B-cell non-Hodgkin lymphoma (iNHL) or mantle cell lymphoma (MCL) (Group 1) and patients with relapsed/refractory diffuse large B-cell lymphoma (rrDLBCL) (Group 2).

Methods: Rituximab 375 mg/m was administered intravenously every 28 days to Group 1 patients on day 1 and every 21 days to Group 2 patients on day 1. Bendamustine 90 mg/m/day was administered to the former on days 1 and 2; bendamustine 120 mg/m/day was administered to the latter on days 2 and 3.

View Article and Find Full Text PDF
Article Synopsis
  • - A nationwide study in Japan analyzed asthma patients (n=1925) to identify different disease phenotypes and potential biomarkers for better treatment options.
  • - Researchers categorized patients into two groups based on severity (GINA 4, 5 and GINA 1-3) and performed statistical analyses to determine distinct clusters of asthma phenotypes, revealing five unique types based on factors like age of onset and blood cell counts.
  • - Key findings suggest that specific biomarkers (like IL-1RA and RANTES) can help classify severe asthma phenotypes, enhancing understanding of asthma management and treatment.
View Article and Find Full Text PDF

Balloon pulmonary angioplasty (BPA) is now a treatment option for patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH). However, the incidence of restenosis and long-term changes in vessel diameters in pulmonary arteries after BPA are unknown. The present study investigated the incidence of restenosis by measuring changes in vessel diameter after BPA.

View Article and Find Full Text PDF

Larger sagittal inter-screw distance/tibial width ratio reduces delayed union or non-union after arthroscopic ankle arthrodesis.

Eur J Orthop Surg Traumatol

July 2023

Department of Orthopaedic Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan.

Background: Arthroscopic ankle arthrodesis (AAA) has risks of complications, such as delayed union and non-union. The number and direction of the inserted screws have been reported as important factors affecting the time to union of AAA. However, the ratio of inter-screw distance (ISD) to tibial width (TW) in different planes has not been investigated.

View Article and Find Full Text PDF

Background: Endoscopic fully-covered self-expandable metal stents (FCSEMSs) are used to treat benign biliary strictures (BBSs); however, treatment for perihilar BBSs is technically challenging. The aim of this study was to evaluate the usefulness of an unflared FCSEMS designed for intraductal placement in patients with refractory perihilar BBS.

Methods: Twenty-two consecutive patients with perihilar BBS unresolved by endoscopic plastic stent placement at 13 tertiary medical centers were prospectively enrolled.

View Article and Find Full Text PDF

Background: In the pivotal phase III, randomized, multicenter ICARIA-MM study (NCT02990338), isatuximab plus pomalidomide and dexamethasone (Isa-Pd) improved progression-free survival and overall response rate versus pomalidomide and dexamethasone (Pd) in the overall population of patients with relapsed/refractory multiple myeloma.

Patients And Methods: In this predefined subgroup analysis, efficacy, and safety between East Asian patients and the overall population were assessed.

Results: In total, 36 East Asian patients were included (Japanese, n = 13; Korean, n = 9; Taiwanese, n = 14).

View Article and Find Full Text PDF