Assessment of future habitat suitability and ecological vulnerability of Collichthys at population and species level.

Background: Global warming and extreme weather events driven by greenhouse gas emissions are significantly impacting fish survival and reproduction, leading to dramatic consequences for marine biodiversity and ecosystem stability. Comparative analysis of closely related species from a phylogenetic perspective provides valuable insights for biodiversity conservation efforts. The study investigates the effects of climate change on the suitability of habitat and ecological vulnerability of two important sibling fishes, Collichthys lucidus and Collichthys niveatus, in the western Pacific.

Cross-cultural adaptation and validation of the Chinese version of the modified Fresno test for physical therapists.

Background: The modified Fresno test was developed to assess knowledge and skills related to evidence-based practice among physical therapists and students, however no Chinese version is available. Therefore, the aim of this study was to cross-culturally adapt the English version of the modified Fresno test into Chinese and to evaluate its validity and reliability.

Methods: This was a cross-sectional validation study.

Gerbils without Borders: Invasiveness, Plague, and Micro-Global Histories of Science, 1932-1939.

In the 1930s, a series of bubonic plague outbreaks among humans cropped up in several villages at the border of Angola and Namibia. These outbreaks provoked deep concern, laying bare social and political tensions amongst neighboring imperial powers and Indigenous people within the region. Despite the appearance of this disease in what was then considered a recondite place, its spread sparked debate in transnational forums, such as the League of Nations and the Office International d'Hygiène Publique.

Unusual Inertness of a Ta Cluster in Dinitrogen Reactions.

Clusters serve as the optimal model to elucidate the structure-property relationship of materials, bridging condensed matter and individual atoms. The pursuit of exceptionally stable clusters has garnered significant interest. The distinctive electronic configuration and symmetrical geometry generally provide a consistent rationale for their stability.

The composition of England's single-qualification OMFS posts: a descriptive analysis of foundation year and dental core training posts.

Postgraduate exposure to oral and maxillofacial surgery (OMFS) for medical and dental graduates differs significantly. To our knowledge, the availability and opportunities provided by these single-qualification posts have not previously been explored. We investigated the number of OMFS posts available for foundation year (FY) doctors and dental core trainees (DCTs) by using information from UK foundation schools and analysing data from Health Education England (HEE) and the UK Foundation Programme Office (UKFPO).

[A national survey from the French Society of Pathology on research and application of artificial intelligence in pathology].

The 2030 French Innovation Healthcare national plan defined "Digital Healthcare" as one of its priority. The deployment of digital pathology and artificial intelligence fits perfectly into this framework. Therefore we evaluated the pathologist's interest in those fields by conducting an online survey among members of the French Society of Pathology, mainly composed of senior pathologists and trainees (n=2301).

A Phase II, Open Label, Single-Arm Study on the Efficacy of Cabozantinib in Patients With Advanced/Metastatic Nonsmall Cell Lung Cancer Harboring MET Exon 14 Alterations who Developed Acquired Resistance to Tepotinib or Capmatinib (CAPTURE Trial).

Background: MET gene exon 14 skipping was identified as a potential driver mutation that occurs in approximately 3%-4% of patients with nonsmall cell lung cancer (NSCLC), typically in the absence of other driver mutations. Capmatinib and tepotinib were the first MET- tyrosine kinase inhibitors (MET-TKIs) approved by the FDA and PMDA, specifically for patients with metastatic NSCLC. Several studies have reported acquired resistance after MET-TKI treatment for MET mutation-positive NSCLC.

Cost-of-illness analysis of chronic urticaria clinical management in five countries of Latin America.

Introduction: Chronic spontaneous urticaria (CSU) is a disease with a high impact on the quality of life of patients. There are some evaluations of the economic cost of the disease in developed countries, but there is little information about the economic cost of the disease in developing countries. Our aim was to assess the economic diagnostic and therapeutic expenses of CSU in five Latin American (LA) countries.

[Research progress on the role of calcium ion transport in dental biomineralization].

Tooth development is a complex biomineralization process formed through the interaction between epithelial tissue and mesenchymal tissue. The Ca transport channel is the intrinsic regulatory mechanism of this process, which regulates the concentration of Ca inside and outside the cell in time and space, thereby affecting the biological functions of various cells and the growth of extracellular hydroxyapatite. This article reviews the researches on the effects of Ca transport in tooth biomineralization and corresponding cell development in recent years, with the aim of providing ideas and basis for the prevention of tooth developmental defects, assisting in early clinical diagnosis, and improving treatment methods.

[Research advances in tooth development studies based on single-cell RNA sequencing].

Tooth development is a complex process of the orderly interaction between epithelium originating from the ectoderm and mesenchyme derived from cranial neural crest cells, which not only depends on cell genes regulatory network but also involves crosstalk between cells and their surrounding environment. Even within the same type of cellular populations, obvious heterogeneity may be observed. Single-cell RNA sequencing is a novel technology aimed at sequencing the transcriptome of individual cell.

[WWP1 plays a positive role in ameloblast differentiation and enamel formation in mice].

To investigate the role of WW domain containing E3 ubiquitin protein ligase 1 (WWP1) in enamel development of mice. Single-cell RNA sequencing data of incisor tissues of postnatal day 7 (P7) mice and mandibular first molar tooth germs of P3.5 mice were used to analyze the expression of WWP1 in dental epithelial cells.

[Single-cell spatiotemporal atlas of tooth development: progress and prospects].

Single-cell and spatial multi-omics technologies enable the simultaneous analysis of thousands of cells in various states, revealing their transcriptional profiles, chromatin accessibility, and spatial positioning. Recent advances in single-cell multi-omics have led to significant discoveries regarding the definition, function, evolution, and interaction of various cell subtypes during tooth development. We summarize key findings from recent single-cell multi-omics studies on tooth development, highlighting their contributions to the field and discussing future perspectives in dental developmental genomics research.

[Guidelines for computer-aided design/computer-aided manufacturing custom fiber post-and-core].

The post-and-core is a widely accepted method to restore endodontically treated teeth with compromised tooth structure. Currently, cast metal post-and-core systems and prefabricated fiber posts combined with composite resin cores are the most frequently options in dental clinical practice, but both also come with advantages and limitations. The development of computer-aided design/computer-aided manufacturing (CAD/CAM) custom fiber post-and-core represents one of the significant trends in the advancement of dentistry.

[Statin for the prevention and treatment of hepatocellular carcinoma: use or wait?].

Hepatocellular carcinoma (HCC) is a kind of malignant tumor with an extremely high morbidity and mortality incidence rate. Although some new progress has been made in recent treatment, the overall prognosis is still poor. Therefore, the prevention and treatment of HCC have important clinical significance.

Pedicle ossification following mandibular reconstruction using fibular free flap in a patient with osteoradionecrosis of the jaw: a case report.

Pedicle ossification is a rare but significant complication following mandibular reconstruction using a fibular free flap (FFF), a technique widely employed in maxillofacial surgery due to its reliable vascularized bone supply and low donor site morbidity. The FFF supports dental implantation and prosthetic rehabilitation, with its vascularized periosteum enhancing osteogenic potential. Despite these advantages, unexpected ossification of the flap's vascular pedicle may occur, potentially mimicking tumor recurrence and causing diagnostic uncertainty.

Delayed inflammation after biodegradable and osteoconductive osteofixation in orthognathic surgery.

Objectives: This study aims to identify patterns and to describe the clinical course of delayed adverse tissue responses in patients who underwent orthognathic osteotomy with biodegradable osteofixation.

Patients And Methods: Through a retrospective review of cases between 2013 and 2020, we identified three patients who underwent bimaxillary osteotomy and fixation with unsintered-hydroxyapatite/poly-L lactic acid (u-HA/PLLA) devices, after which they developed delayed inflammation. These lesions were treated with drainage and/or removal of the devices.

Retrospective analysis of characteristics of patients presenting to the emergency room following dental treatment.

Objectives: This study is a retrospective analysis of patients who visited the emergency room (ER) following dental treatment over a period of 3 years, with the aim to enhance the understanding of emergency situations that may arise after dental procedures and to develop appropriate postoperative management and emergency care methods.

Patients And Methods: A total of 796 emergency patients whose visits were attributed to dental procedures, of 4,241 patients who visited the ER at Pusan National University Yangsan Hospital from January 2021 to January 2024, was included in the study. Patients were categorized based on the reason for visit into bleeding, inflammation, and other categories.

Residual hyperglycemia after successful treatment of a patient with severe copper sulfate poisoning.

Copper sulfate is a frequently used copper compound in laboratory settings, with instances of poisoning being uncommon. A study conducted by the American Association of Poison Control Centers' National Poison Data System found that only 140 individuals were exposed to copper compounds over the course of a year, with five cases being intentional (Gummin et al., 2023).

Deciphering odontogenic myxoma: the role of copy number variations as diagnostic signatures.

In light of the lack of reliable molecular markers for odontogenic myxoma (OM), the detection of copy number variation (CNV) may present a more objective method for assessing ambiguous cases. In this study, we employed multiregional microdissection sequencing to integrate morphological features with genomic profiling. This allowed us to reveal the CNV profiles of OM and compare them with dental papilla (DP), dental follicle (DF), and odontogenic fibroma (OF) tissues.

Implications of bacteria‒bacteria interactions within the plant microbiota for plant health and productivity.

Crop production currently relies on the widespread use of agrochemicals to ensure food security. This practice is considered unsustainable, yet has no viable alternative at present. The plant microbiota can fulfil various functions for its host, some of which could be the basis for developing sustainable protection and fertilization strategies for plants without relying on chemicals.

[Correlation of Mutation with Clinical Features and Prognosis of Langerhans Cell Histiocytosis in Cildren].

Objective: To explore the gene mutations of Langerhans cell histiocytosis in children, and to analyze the correlation of mutation with clinical features and prognosis of LCH, so as to provide reference for clinical diagnosis and treatment.

Methods: Fluorescence PCR was used to detect gene mutations in paraffin-embedded tissue samples from 78 children with LCH, and the correlation of mutation with clinical characteristics and prognosis of LCH in children was analyzed.

Results: Among the 78 children, 41 cases (52.

Embedding Specialised Educators in Modalities for Continuing Medical Education. A Study of Effectiveness, and Health Care Practitioner and Educator Preferences.

Introduction: As the delivery of continuing medical education moves towards digital modes, determining how to embed and capitalise on the skills of specialised educators in digital modalities is critical. Drawing on social theories of adult learning and behaviour change, this study trialled multiple delivery modes of education about reproductive genetic 'carrier screening' with varying levels of specialised educator (genetic counsellors) input to examine clinical effectiveness, and health care practitioners and educator preferences.

Methods: A subset of health care practitioners (n = 209) interested in offering carrier screening through a large study were randomly allocated to receive education via face-to-face, a pre-recorded video or an online module, with active or passive educator input.

The Influence of Dietary Habits on Male Lower Urinary Tract Symptoms: Differential Influence of Water Intake on Voiding Symptoms and Storage Symptoms.

Purpose: To investigate the dietary factors affecting male lower urinary tract symptoms (LUTS).

Materials And Methods: This retrospective study analyzed men who underwent health check-ups. The men who completed the International Prostate Symptom Score (IPSS) and a dietary questionnaire with 19 items were included in the study.

Multi-omics approach reveals TGF-β signaling-driven senescence in periodontium stem cells.

Introduction: The periodontal ligament (PDL), a dynamic connective tissue that anchors teeth to the alveolar bone, enables tooth retention and facilitates continuous turnover. The integrity of the periodontium is maintained by periodontal ligament stem cells (PDLSCs), whose dysfunction and senescence with age can disrupt tissue homeostasis, hinder injury repair, and lead to tooth loss, ultimately impacting overall health. Transforming growth factor-β1 (TGF-β1) is known for its regenerative properties and as a functional paracrine factor in stem cell therapy, but its precise role in modulating PDLSC activity remains controversial and poorly understood.

The novel assessment to explore the cutting performance of rotary instruments using dynamic finite element analysis with failure mode.

Introduction: The separation of nickel-titanium endodontic instruments due to excessive torque adversely affects treatment outcomes. Previous studies have analyzed torque values under static conditions and failed to accurately simulate the dynamic conditions of instruments within root canals. This study aimed to apply a novel finite element analysis (FEA) to assess the real-time dynamic performance of nickel-titanium endodontic instruments during operation in root canals.