382 results match your criteria: "National Defence University of Malaysia[Affiliation]"

Exploring the Antarctic aminopeptidase P from sp. strain AMS3 through structural analysis and molecular dynamics simulation.

J Biomol Struct Dyn

March 2024

Enzyme and Microbial Technology Research Centre, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.

Aminopeptidase P (APPro) is a crucial metalloaminopeptidase involved in amino acid cleavage from peptide N-termini, playing essential roles as versatile biocatalysts with applications ranging from pharmaceuticals to industrial processes. Despite acknowledging its potential for catalysis in lower temperatures, detailed molecular basis and biotechnological implications in cold environments are yet to be explored. Therefore, this research aims to investigate the molecular mechanisms underlying the cold-adapted characteristics of APPro from sp.

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Background infection has been identified to cause constantly recurring inflammation, leading to gastrointestinal tract disorders, including carcinoma. The standard triple therapy (STT), used to eradicate includes two antimicrobials and a proton pump inhibitor for two weeks. Other drug regimens have also been developed since exhibits antimicrobial resistance.

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In recent years, the rise of antibiotic-resistant bacteria has posed a severe threat to global public health, necessitating innovative and alternative approaches to combat this escalating crisis. Bacteriophages, viruses that infect and replicate within bacteria, have emerged as promising candidates for therapeutic intervention against antibiotic-resistant pathogens. This study delves into the intricate landscape of bacteriophage research, unraveling the trends and impact of research in the field.

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Bibliometric Analysis of Research Papers on Academic Stress (1989-2023).

Cureus

March 2024

Department of Periodontology and Implantology, Karnavati School of Dentistry, Karnavati University, Gandhinagar, IND.

This extensive study provides a comprehensive overview of the contemporary research landscape about academic stress, emphasizing on identifying the most relevant contributors and understanding prevalent trends. The analysis included 5,375 results from the PubMed database and revealed a consistent upward trajectory with fluctuations in research paper publications over the years. Network analysis and visualization were performed using the Biblioshiny app and VOSviewer software.

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Aerobic exercise is a widely adopted practice, not solely for enhancing fitness and reducing the risk of various diseases but also for its ability to uplift mood and aid in addressing depression and anxiety disorders. Within the scope of this narrative review, we seek to consolidate current insights into the endocannabinoid-mediated regulation of stress and the brain's reward mechanism resulting from engaging in aerobic exercise. A comprehensive search was conducted across Medline, SPORTDiscus, Pubmed, and Scopus, encompassing data available until November 30, 2023.

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Mapping the Evolution of Clinical Trials on Drug-Resistant Tuberculosis: A Bibliometric Overview (1965-2023).

Cureus

February 2024

Department of Periodontology and Implantology, Karnavati School of Dentistry, Karnavati University, Gandhinagar, IND.

This study provides a comprehensive overview of the current landscape in drug-resistant tuberculosis research. An extensive electronic search was conducted on PubMed and Scopus databases to identify clinical trials related to drug-resistant tuberculosis. Network analysis and visualization were performed on the data using the Biblioshiny App and VOSviewer software.

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Introduction The emergence of antimicrobial resistance (AMR) is driven by the selection pressure of frequent uses of antimicrobial agents in healthcare, the food chain, agriculture, fishery, and the food animal industry, which poses a serious health risk for transmission-linked humans and the surrounding environment. Livestock, particularly cattle, play an essential role in the food sector in Bangladesh. The food-animal chains can be the potential routes of exposure to AMR-microorganisms for every domain of one health.

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Nitrocellulose (NC) has garnered significant interest among researchers due to its versatile applications, contingent upon the degree of nitration that modifies the cellulose structure. For instance, NC with a high nitrogen content, exceeding 12.5%, finds utility as a key ingredient in propellant formulations, while variants with lower nitrogen content prove suitable for a range of other applications, including the formulation of printing inks, varnishes, and coatings.

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Exploring the Perspective of Oral Microbiome Studies in PubMed Database: A Bibliometric Appraisal.

Cureus

February 2024

Periodontology and Implantology, Karnavati Scientific Research Center (KSRC) Karnavati School of Dentistry, Karnavati University, Gandhinagar, IND.

This research aims to postulate an exhaustive sketch of the current research background on the oral microbiome to emphasize prevailing research trends. On November 25, 2023, a digital exploration was conducted on the PubMed platform. The search strategy employed was- '(Microbiome, Microbiota, Microorganisms, Bacteria, Virus, Fungi) AND (Oral, Dental, Saliva, Plaque, Gingival Crevicular Fluid)'.

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Conducted on randomized clinical trials (RCTs) addressing antibiotic resistance in the PubMed database, this bibliometric analysis explores relevant sources, keyword co-occurrence, institutional co-authorship, global collaboration patterns, and evolving research trends. Utilizing an electronic search on January 13, 2024, employing the term "antibiotic resistance," 252,657 results were retrieved, of which 2,962 RCTs were analyzed. The dissemination of RCTs exhibited a variable distribution from 1965 to 2023, with a peak in 2014, noteworthy peaks in 1993-1994 and 2002-2003, contrasting declines in 1990-1991 and 2007-2008, and a consistent decrease post 2018.

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Constipation suffered by children is a global public health problem. Functional constipation (FC) brings about deteriorating effects in the children's lives who suffer from it. The risk factors for the development of constipation include the consumption of a diet low in fiber and high in calories (such as the consumption of fast food), a sedentary lifestyle with a lack of exercise, a family history of constipation, and emotional and psychological stress endured by children in their families.

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Introduction: In Malaysia, the prevalence of depression has increased from 1.8 % to 2.3 % within a decade.

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Background Lockdown measures to reduce the outbreak of COVID-19 negatively impacted the administration of cancer chemotherapy globally; however, data from Kenya are limited. Researchers strove to address this information gap and assess chemotherapy trends before and during the pandemic at Kenyatta National Hospital (KNH), the most wide-ranging referral infirmary in Kenya, along with associated factors to provide future guidance. Methods Time series analyses and patient interviews were undertaken at the KNH Cancer Treatment Centre.

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Introduction Estimating ovarian reserve has been the cornerstone of designing treatment plans for female infertility over the last few years. The most reliable biomarker for assessing female fertility is the antral follicle count (AFC). Also, the anti-müllerian hormone (AMH) is a sensitive test for predicting ovarian reserve and is precisely associated with AFC value.

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The climate, geomorphological changes, and hydrological elements that have occurred have all influenced future flood episodes by increasing the likelihood and intensity of extreme weather occurrences like extreme precipitation events. River bank erosion is a natural geomorphic process that occurs in all channels. As modifications of sizes and channel shapes are made to transport the discharge, sediment abounds from the stream catchment, and floods are triggered dramatically.

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Article Synopsis
  • Magnesium (Mg) is a key intracellular ion crucial for various bodily functions, acting as a calcium antagonist that supports neuromuscular activities.
  • An imbalance in Mg levels can lead to a range of clinical issues, from mild symptoms to life-threatening complications, and it is often overlooked in medical evaluations.
  • The review emphasizes the importance of accurate Mg measurements and how they can impact diagnosis and treatment, highlighting its interrelationship with other electrolytes like potassium (K) and calcium (Ca).
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Background Adequate community-based or societal collaboration and cooperation are considerably important for the overall welfare of women and adolescent girls with disabilities. "The Multidimensional Scale of Perceived Social Support (MSPSS)" has not been evaluated for reliability and validity amid women and adolescent girls with disabilities in the Bangladeshi context. Methods A Bangla-translated form of the MSPSS was constructed, and the survey was conducted among 152 women and adolescent girls with disabilities who were purposefully recruited from Bogura Sadar and Chapainawabganj Sadar sub-districts of Bangladesh.

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Molten salt synthesis of disordered spinel CoFeO with improved electrochemical performance for sodium-ion batteries.

RSC Adv

November 2023

Department of Materials and Metallurgical Engineering, Institut Teknologi Sepuluh Nopember Surabaya 60111 Indonesia

Sodium-ion (Na-ion) batteries are currently being investigated as an attractive substitute for lithium-ion (Li-ion) batteries in large energy storage systems because of the more abundant and less expensive supply of Na than Li. However, the reversible capacity of Na-ions is limited because Na possesses a large ionic radius and has a higher standard electrode potential than that of Li, making it challenging to obtain electrode materials that are capable of storing large quantities of Na-ions. This study investigates the potential of CoFeO synthesised the molten salt method as an anode for Na-ion batteries.

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Worldwide trend discovery of structural and functional relationship of metallo-β-lactamase for structure-based drug design: A bibliometric evaluation and patent analysis.

Int J Biol Macromol

January 2024

Enzyme and Microbial Technology Research Center, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia; Department of Biochemistry, Faculty of Biotechnology and Biomolecular Science, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia. Electronic address:

Metallo-β-lactamase (MBL) is an enzyme produced by clinically important bacteria that can inactivate many commonly used antibiotics, making them a significant concern in treating bacterial infections and the risk of having high antibiotic resistance issues among the community. This review presents a bibliometric and patent analysis of MBL worldwide research trend based on the Scopus and World Intellectual Property Organization databases in 2013-2022. Based on the keywords related to MBL in the article title, abstract, and keywords, 592 research articles were retrieved for further analysis using various tools such as Microsoft Excel to determine the frequency analysis, VOSviewer for bibliometric networks visualization, and Harzing's Publish or Perish for citation metrics analysis.

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Cost effectiveness of quadrivalent influenza vaccines in the elderly population of Malaysia.

Sci Rep

October 2023

International Centre for Casemix and Clinical Coding, Hospital Canselor Tuanku Muhriz, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia.

The economic burden of influenza is a significant issue within healthcare system, related to higher medical costs particularly among the elderly. Yet, influenza vaccination rates in the elderly in Malaysia were considerably low as it is not part of Malaysia's national immunization program, with substantial mortality and morbidity consequences. Therefore, we conducted a cost-effectiveness analysis of quadrivalent influenza vaccine (QIV) for the elderly in Malaysia compared with the current no-vaccination policy.

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Vitamin D and Periodontal Health: A Systematic Review.

Cureus

October 2023

Periodontology and Implantology, Karnavati School of Dentistry, Karnavati University, Gandhinagar, IND.

Article Synopsis
  • - The systematic review assesses the role of vitamin D (specifically cholecalciferol) in periodontal health, indicating that while there's a recognized connection, the current literature shows significant variability and gaps in research findings.
  • - A thorough search across multiple databases led to the evaluation of 1883 papers, ultimately narrowing it down to four studies that meet the inclusion criteria for assessing vitamin D's impact on oral health.
  • - The review highlights vitamin D's dual role in oral health: supporting bone metabolism and acting as an anti-inflammatory agent, while also stressing the need for more consistent and high-quality research on the topic.
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Introduction The overlap in clinical presentation between COVID-19 and dengue poses challenges for diagnosis in co-endemic regions. Furthermore, there have been reports of antibody cross-reactivity between SARS-CoV-2 and dengue. Our research aims to evaluate SARS-CoV-2 antigens for serological testing while reducing the possibility of cross-reactivity with anti-dengue antibodies.

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Background Ridge preservation became a crucial dental health issue and strategy to keep away from ridge defacement after post-tooth loss. The recent scientific evolution of platelet-rich fibrin (PRF) comprises a parenteral formulation of PRF. The combined allograft for socket preservation gives benefits.

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Enhanced tribological properties of diesel-based engine oil through synergistic MoS-graphene nanohybrid additive.

Sci Rep

October 2023

Sunway Centre for Electrochemical Energy and Sustainable Technology (SCEEST), School of Engineering and Technology, Sunway University, No. 5 Jalan Universiti, Bandar Sunway, 47500, Petaling Jaya, Selangor, Malaysia.

This research explores the potential of microwave-synthesized MoS-graphene nanohybrid as additives to enhance the tribological properties of diesel-based engine oil. The synthesis method offers significant advantages, reducing both synthesis time and energy consumption by 90-98% compared to conventional approaches. The synthesized nanohybrids are characterized through FESEM, EDX, XRD, and Raman spectroscopy to understand their morphology and functional group interactions.

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