Optimizing coastal groundwater quality predictions: A novel data mining framework with cross-validation, bootstrapping, and entropy analysis.

Investigating the potential of novel data mining algorithms (DMAs) for modeling groundwater quality in coastal areas is an important requirement for groundwater resource management, especially in the coastal region of Bangladesh where groundwater is highly contaminated. In this work, the applicability of DMA, including Gaussian Process Regression (GPR), Bayesian Ridge Regression (BRR) and Artificial Neural Network (ANN), for predicting groundwater quality in coastal areas was investigated. The optuna-based optimized hyperparameter is proposed to improve the accuracy of the models, including optuna-GPR and optuna-BRR as benchmark models.

Impact of Gd doping on structural and magnetic characteristics of SrFeOperovskite nanomaterial.

The SrFeOnanoparticles doped with 5% and 10% Gd were synthesized using the solution combustion method. The phase formation of the synthesized nanoparticles was confirmed by powder x-ray diffraction analysis. Field emission scanning electron microscope and HRTEM were employed to examine the morphology of the samples, revealing well-ordered, agglomerated nanoparticles.

Tuberculosis vaccine - A timely analysis of the drawbacks for the development of novel vaccines.

The BCG vaccine, Bacille Calmette Guerin, holds the distinction of being the most widely administered vaccine. Remarkably, a century has passed since its discovery; however, puzzlingly, questions persist regarding the effectiveness of the immune response it triggers. After years of diligent observation, it has been deduced that BCG imparts immunity primarily to a specific age group, namely children.

Impact of climate change on vector-borne diseases: Exploring hotspots, recent trends and future outlooks in Bangladesh.

Climate change is a significant risk multiplier and profoundly influences the transmission dynamics, geographical distribution, and resurgence of vector-borne diseases (VBDs). Bangladesh has a noticeable rise in VBDs attributed to climate change. Despite the severity of this issue, the interconnections between climate change and VBDs in Bangladesh have yet to be thoroughly explored.

Beyond digital interfaces: The human element in online teaching and its influence on student experiences.

Amidst the digital transformation of education, the essence of the human touch in online teaching remains pivotal. Despite growing literature, there remains a significant gap in understanding how the human element in online teaching directly influences student engagement and learning outcomes, especially in diverse educational contexts. This study develops a quantifiable index capturing the essence of humanized online teaching and investigates the determinants influencing this humanization.

Impressive promiscuous biomimetic models of ascorbate, amine, and catechol oxidases.

Copper metalloenzymes ascorbate oxidase (AOase), amine oxidase (AmOase), and catechol oxidase (COase) possess copper(II) sites of coordination, which are trimeric, homodimeric, and dimeric, respectively. Two newly mononuclear copper(II) complexes, namely, [Cu(L)(bpy)](ClO) (1) and [Cu(L)(phen)](ClO) (2) where HL = Schiff base, have been synthesized. UV-visible, EPR and single-crystal X-ray diffraction examinations were used to validate the geometry in solution and solid state.

Association of Atrazine-Induced Overexpression of Aldo-Keto-Reductase 1C2 (AKR1C2) with Hypoandrogenism and Infertility: An Experimental Study in Male Wistar Rat.

Atrazine (ATZ, CHClN) is a widely used synthetic herbicide that contaminates drinking water. It is a known endocrine disruptor that disrupts various molecular pathways involved in hormone signaling, and DNA damage, and can cause reproductive disorders, including decreased fertility, and abnormal development of reproductive organs, as revealed in animal model studies. However, the effect of ATZ on steroidogenesis in the male reproductive system, especially reduction of ketosteroids to hydroxysteroids, remains unclear.

Exploring Therapeutic Potential of Catalase: Strategies in Disease Prevention and Management.

The antioxidant defense mechanisms play a critical role in mitigating the deleterious effects of reactive oxygen species (ROS). Catalase stands out as a paramount enzymatic antioxidant. It efficiently catalyzes the decomposition of hydrogen peroxide (HO) into water and oxygen, a potentially harmful byproduct of cellular metabolism.

Assessing metal(loid)s-Induced long-term spatiotemporal health risks in Coastal Regions, Bay of Bengal: A chemometric study.

Despite sporadic and irregular studies on heavy metal(loid)s health risks in water, fish, and soil in the coastal areas of the Bay of Bengal, no chemometric approaches have been applied to assess the human health risks comprehensively. This review aims to employ chemometric analysis to evaluate the long-term spatiotemporal health risks of metal(loid)s e.g.

Integrated approach to understand the multiple natural and anthropogenic stresses on intensively irrigated coastal aquifer in the Mediterranean region.

Understanding the major factors influencing groundwater chemistry and its evolution in irrigation areas is crucial for efficient irrigation management. Major ions and isotopes (δD-HO together with δO-HO) were used to identify the natural and anthropogenic factors contributing to groundwater salinization in the shallow aquifer of the Wadi Guenniche Plain (WGP) in the Mediterranean region of Tunisia. A comprehensive geochemical investigation of groundwater was conducted during both the low irrigation season (L-IR) and the high irrigation season (H-IR).

Production, optimization and characterization of partially purified anti-mycotic compound from marine soil derived streptomycetes originating at unexplored region of Bay of Bengal, India.

Sixty-eight morphologically distinct isolates of marine actinomycetes were derived from seashore, mangrove, and saltpan ecosystems located between the Palk Strait and Gulf of Mannar region, Bay of Bengal, Tamilnadu. Twenty-five (36.8%) isolates exhibited anti-mycotic activity against Candida albicans and Cryptococcus neoformans in preliminary screening, and 4 isolates with prominent activity were identified and designated at the genus level as Streptomyces sp.

infection in a stranded striped dolphin (Meyen, 1833) on the Southwest coastline of India.

Necropsy on a striped dolphin (Meyen, 1833) entangled in ghost fishing net and dead while rescuing yielded some helminth parasites, later identified as . DNA barcoding of the host and parasite and the phylogenetic analysis of the parasite was conducted. This study provides valuable information towards establishing basal data of marine mammal parasite diversity and distribution in the Indian waters.

Fine-Tuned Graphene Oxide Nanocomposite: Harnessing Copper(II)-Imidazole Complex for Enhanced Biological Responses and Balanced Photocatalytic Functionality.

In this study, the synthesis of biologically active copper(II) complex [Cu(im)]Cl was achieved using a reported method. Subsequently, this copper(II) complex was strategically grafted onto graphene oxide, resulting in the formation of a nanocomposite denoted as copper(II)-complex-grafted graphene oxide (Cu-GO). The comprehensive characterization of Cu-GO was conducted through various techniques, including X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), UV-visible spectroscopy, emission spectra analysis, X-ray photoelectron spectroscopy (XPS), and Copper K-edge X-ray Absorption Near Edge Structure (XANES) spectroscopy.

Silica/ nano-hybrid: Synthesis and anticancer activity against breast cancer.

Biogenically derived silica nanoparticles may serve as a well-defined target vehicle for drug delivery and have a wide range of applications in biomedicine. Silica nanoparticles are an excellent candidate as drug carriers due to their mesoporous structure, high drug loading capacity, low toxicity, environmental friendliness and low economic synthesis procedures. In this study, nano structured silica was extracted from sugarcane bagasse through an alkali leaching extraction and conjugated with extract overcoming its poor solubility and improving its bioavailability within the host system.

Harnessing the power of mollusc lectins as immuno-protective biomolecules.

The rapid advancement of molecular research on macromolecules has contributed to the discovery of 'Lectin', a carbohydrate-binding protein which specifically interacts with receptors on the surface of glycans and regulates various cellular activities thereby stimulating immunological functions. Considering the wide variety of sources and immunological significance, research has led to the discovery of lectins in invertebrate molluscs. Such lectins in molluscs mediate active immune response as they lack adaptive immunity.

Unravelling the Untapped Pharmacological Potential of Plant Molecules as Inhibitors of BACE1: In Silico Explorations for Alzheimer's Disease.

Alzheimer's disease (AD) is an extremely complex, heterogeneous, and multifactorial neurodegenerative disease clinically characterized by progressive memory loss and progressive decline in cognitive function. There is currently no effective treatment for the onset and/or progression of the pathophysiological diseases of AD. The global prevalence of this disease has increased in recent years due to modern lifestyle.

Random mutagenesis as a tool for industrial strain improvement for enhanced production of antibiotics: a review.

Secondary metabolites are produced by microbes in minimal quantities in the natural environment out of necessity. However, in the pharmaceutical industry, their overproduction becomes essential. To achieve higher yields, genetic modifications are employed to create strains that surpass the productivity of the initially isolated strains.

Polyol synthesis of one-dimensional Ag nanowires for the photocatalytic degradation of textile dye and effective removal of microbes.

Due to the excess release of hazardous pollutants to the environment, the quest for the synthesis of effective nanomaterials for wastewater treatment is never-ending. Present study reports the polyol synthesis of Ag NWs of ~ 85 nm diameter and average length of 4.08 µm using PVP and ethylene glycol.

Ectopic pregnancy: search for biomarker in salivary proteome.

Ectopic pregnancy (EP) is associated with high maternal morbidity and mortality. Ultrasonography is the only dependable diagnostic tool for confirming an ectopic pregnancy. In view of inadequate early detection methods, women suffer from a high-life risk due to the severity of EP.

Protective effect of quercetin and thymoquinone against genotoxicity and oxidative stress induced by ZnO nanoparticles in the Wistar rat model.

Zinc oxide nanoparticles (ZnO-NPs) are increasingly used in a variety of consumer and other commercial products. Hence, man faces the risk of exposure to ZnO-NPs and the consequent adverse health effects. Mitigation/prevention of such effects using natural products has drawn the attention of scientists.

Control and prevention of microbially influenced corrosion using cephalopod chitosan and its derivatives: A review.

Microbially influenced corrosion (MIC) of metals is an important industrial problem, causing 300-500 billion dollars of economic loss worldwide each year. It is very challenging to prevent or control the MIC in the marine environment. Eco-friendly coatings embedded with corrosion inhibitors developed from natural products may be a successful approach for MIC prevention or control.