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Morphologic and Immunohistochemical Study of Clear Cell Carcinoma of the Uterine Endometrium and Cervix in Comparison to Ovarian Clear Cell Carcinoma.

Int J Gynecol Pathol

July 2018

Department of Family Planning, the Second Hospital of Tianjin Medical University (B.J., J.W.) Departments of Pathology (B.Y., L.S., Y.G., J.W.) Gynecological Cancer (Q.H.), Tianjin Medical University Cancer Institute and Hospital Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center of Cancer (B.Y., L.S., Y.G., Q.H., J.W.), Tianjin, China.

Endometrial clear cell carcinoma (ECCC) and clear cell adenocarcinoma of the cervix (CCAC) are uncommon gynecologic cancers that have morphologic and phenotypic features similar to ovarian clear cell carcinoma (OCCC), but the 3 entities may not be completely identical. This study identified the morphologic and phenotypic characteristics and the differences between ECCC and CCAC in comparison to OCCC. The morphologic features of 16 ECCCs, 7 CCACs, and 22 OCCCs are described.

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