23,015 results match your criteria: "National Cheng Kung University[Affiliation]"
J Oral Biosci
December 2024
Department of Life Sciences, National Cheng Kung University, Tainan, Taiwan R.O.C; Marine Biology and Cetacean Research Center, National Cheng Kung University, Tainan, Taiwan R.O.C. Electronic address:
Objective: Drug resistance and subsequent adverse effects, such as cancer cachexia, limit the clinical use of cisplatin. Oligonol® (Olg), a low-molecular-weight polyphenol, exhibits NF-κB inhibitory properties. NF-κB activation has been implicated in cisplatin resistance of cancer cells and skeletal muscle wasting.
View Article and Find Full Text PDFTransl Oncol
December 2024
Liver Research Center, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan. Electronic address:
Liver cancer, encompassing hepatocellular carcinoma (HCC) and hepatoblastoma, the latter of which primarily occurs in early childhood, is the most common malignant tumor arising from liver and is responsible for a significant number of cancer-related deaths worldwide. Targeted drugs have been used for anti-liver cancer treatment in the advanced stage, while their efficacy is greatly compromised by development of drug resistance. Drug resistance is a complicated process regulated by intrinsic and extrinsic signals and has been associated with poorer prognosis in cancer patients.
View Article and Find Full Text PDFHypertens Res
December 2024
Department of Internal Medicine, National Cheng-Kung University Hospital, Tainan, Taiwan.
The synergistic interplay between cortisol and aldosterone is critical for maintaining homeostasis, particularly in blood pressure regulation, fluid balance, and stress response. Cortisol, a glucocorticoid, and aldosterone, a mineralocorticoid, often act in tandem to regulate sodium retention and blood volume. Dysregulation of these hormones, as seen in hyperaldosteronism or Cushing's syndrome, contributes to hypertension and metabolic imbalances.
View Article and Find Full Text PDFClin Ther
December 2024
Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:
Purpose: Intraoperative topical vancomycin has been widely used in several surgical fields to prevent wound infection. However, there have been limited studies on the systemic exposure of topical vancomycin. The aim of this study was to investigate systemic exposure after topical vancomycin over the sternal edge in cardiac surgical patients.
View Article and Find Full Text PDFLancet Neurol
January 2025
Neuroimmunology Program, Institut d'Investigacions Biomèdiques August Pi i Sunyer/CaixaResearch Institute, Hospital Clínic de Barcelona, Barcelona, Spain; Pediatric Neuroimmunology Unit, Neurology Department, Sant Joan de Déu Children's Hospital, Barcelona, Spain; Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain; European Reference Networks-RITA. Electronic address:
Background: The usefulness of current diagnostic approaches in children with suspected autoimmune encephalitis is unknown. We aimed to assess the diagnosis of autoimmune encephalitis in clinical practice and to compare the performance of two international diagnostic algorithms (one intended for patients of any age [general], the other intended for paediatric patients), with particular emphasis on the evaluation of patients with probable antibody-negative autoimmune encephalitis because this diagnosis suggests that immunotherapy should be continued or escalated but is difficult to establish.
Methods: We did a prospective cohort study that included all patients (<18 years of age) with suspected autoimmune encephalitis recruited at 40 hospitals in Spain whose physicians provided clinical information every 6 months for 2 years or more.
Value Health
December 2024
Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Pharmacy, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:
Objective: Given the lack of a value framework for assessing health technologies in Asian settings, a value framework incorporating multiple-criteria decision analysis (MCDA) for new drugs under universal healthcare coverage in Taiwan was established.
Methods: The development process included: 1) the adoption of five value domains (i.e.
Bioorg Chem
December 2024
School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. Electronic address:
Septin 9 (SEPT9), a GTPase, known as the fourth cytoskeleton, is widely expressed in various cells and tissues. The functions of SEPT9 are partly similar to other cytoskeletons as a structure protein. Further, SEPT9 can interact with other cytoskeletons, participating in actin dynamics and microtubule regulation.
View Article and Find Full Text PDFAm J Emerg Med
December 2024
Department of Medicine, Division of General Internal and Emergency Medicine, Aarau, Switzerland; Faculty of Medicine, University of Basel, Basel, Switzerland. Electronic address:
Procalcitonin is a useful biomarker for infection. Over the past two decades, there has been much research on the clinical applications of procalcitonin, yet the majority of these studies have been conducted in the intensive care setting. Despite the extensive use of procalcitonin in emergency departments, there have been no guidelines focusing specifically on these clinical settings.
View Article and Find Full Text PDFJ Am Chem Soc
December 2024
Department of Chemical Engineering, National Tsing Hua University, Hsinchu 300044, Taiwan.
Mini-emulsion and nanoprecipitation techniques relied on large amounts of surfactants, and unresolved miscibility issues of heterojunction materials limited their efficiency and applicability in the past. Through our molecular design and developed surfactant-free precipitation method, we successfully fabricated the best miscible bulk-heterojunction-particles (BHJP) ever achieved, using donor () and acceptor () polymers. The structural similarity ensures optimal miscibility, as supported by the interaction parameter of the / blend is positioned very close to the binodal curve.
View Article and Find Full Text PDFInt J Surg
December 2024
Department of Urology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Bipolar Disord
December 2024
School of Nursing, National Taiwan University College of Medicine, Taipei, Taiwan.
J Formos Med Assoc
December 2024
Division of Neurosurgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:
Microbiol Spectr
December 2024
Center for Infection Control, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Unlabelled: Commercial antifungal susceptibility tests were available for clinical yeast isolates. However, the updated Sensititre YeastOne (SYO) version YO10C excluded species for susceptibility testing. Uncorrelation of antifungal susceptibility patterns by SYO and therapeutic outcomes had been recently reported.
View Article and Find Full Text PDFCardiol Rev
December 2024
Department of Environmental and Occupational Health, National Cheng Kung University, Tainan City, Taiwan, R.O.C.
Heart failure (HF) prevalence is rising due to population aging and increasing risk factor incidence, thereby posing a significant global public health challenge. Disease management programs (DMPs) play a crucial role in managing HF and optimizing postevent health outcomes. Through a systematic review and meta-analysis, this study aimed to evaluate the effectiveness of DMPs following an HF event.
View Article and Find Full Text PDFKidney Int Rep
December 2024
Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Heliyon
December 2024
Department of Chemical Engineering, National Cheng Kung University, Tainan, 702, Taiwan.
Increasing attention has been paid to the detection of explosives due to the occurrence of terrorist attacks around the world. Here, we used free radical polymerization to develop two different types of fluorescent copolymers for use in detecting picric acid. One exhibits aggregation-caused quenching (ACQ) and is called PNNS [poly (-isopropyl acrylamide---hydroxymethyl acrylamide --styrene-pyrene), poly (NIPAAm--NMA--St-Py)].
View Article and Find Full Text PDFOTJR (Thorofare N J)
December 2024
International Gaming Research Unit, Psychology Department, Nottingham Trent University, Nottingham, UK.
Intrinsic capacity (IC), an internal composite ability proposed by the World Health Organization, is fundamental to older people's health. The present study examined potential models explaining the association between IC and quality of life (QoL) among older people in Taiwan. Frailty, basic activities of daily living (BADL), and instrumental activities of daily living (IADL) were hypothesized to be mediators in the association between IC and QoL.
View Article and Find Full Text PDFSci Data
December 2024
Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Cardiac regenerative therapy has recently progressed by reprogramming somatic cells into induced pluripotent stem cells (iPSCs) and advanced by large-scale differentiation-derived cardiomyocytes (hiPSC-CMs). However, repairing damaged cardiac tissues with hiPSC-CMs remains limited due to immune rejection, cardiac arrhythmias, and concerns over tumor formation after hiPSC-CM transplantation. Despite efforts in profiling epigenomic changes during cardiac differentiation, regulatory mechanisms underlying 5-methylcytosine (mC) deposition in RNA mC epitranscriptomic landscape during hiPSC-to-cardiomyocyte differentiation remain unclear.
View Article and Find Full Text PDFCurr Pharm Des
December 2024
Department of Pathology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi 600, Taiwan.
Background: Effective management strategies against tick infestations are necessary because tickborne diseases represent serious hazards to the health of humans and animals worldwide. The aim of this study was to examine the larvicidal and ovicidal properties of Xanthium strumarium extract against a notorious tick species, Rhipicephalus microplus.
Methodology: The maceration method was used to prepare the ethanolic extract of X.
ACS Appl Mater Interfaces
December 2024
Department of Materials Science and Engineering, National Cheng Kung University, Tainan 70101, Taiwan.
Components needed in Artificial Intelligence with a higher information capacity are critically needed and have garnered significant attention at the forefront of information technology. This study utilizes solution-processed zinc-tin oxide (ZTO) thin-film phototransistors and modulates the values of , which allows for the regulation of electron trapping/detrapping at the ZTO/SiO interface. By coupling the excited photonic carrier and electronic trapping, logic gates such as "AND," "OR," "NAND," and "NOR" can be achieved.
View Article and Find Full Text PDFChemosphere
December 2024
Center of Excellence in Catalysis for Bioenergy and Renewable Chemicals (CBRC), Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand; Center of Excellence on Petrochemical and Materials Technology (PETROMAT), Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand.
Support Care Cancer
December 2024
Department of Nursing, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Cancer Nurs
December 2024
Author Affiliations: Department of Nursing, College of Medicine, National Cheng Kung University (Dr Y. Y. Hsu and Ms C. F. Hsu); Biomdcare Corporation, New Taipei (Ms Liang); and Nursing Department (Mrs Liu) and Surgery Department (Dr Ho), National Cheng Kung University Hospital; Department of Obstetrics and Gynecology, College of Medicine, National Cheng Kung University (Dr K. F. Hsu); and Obstetrics and Gynecology Department, National Cheng Kung University Hospital (Dr K. F. Hsu), Tainan, Taiwan, Republic of China.
Background: Lower limb lymphedema (LLL) significantly impacts the quality of life in women who have undergone gynecological cancer surgery, limiting their physical activities, household chores, and social interactions. Despite its prevalence, there is a lack of comprehensive understanding of the lived experiences of these women.
Objective: To explore the experiences of LLL in Taiwanese women following gynecological cancer surgery.
Front Oncol
December 2024
Department of Occupational Medicine, Tainan Municipal Hospital (managed by ShowChwan Medical Care Corporation), Tainan, Taiwan.
Introduction: Cancer has emerged as one of the leading causes of fatality all over the world. Phytoconstituents are being studied for their synergistic effects, which include disease prevention by altering molecular pathways and immunomodulation without side effects. The present experiment aims to explore the cancer preventive activities of Linn leaves extract in skin cancer cell lines (A431) and colon cancer cell lines (COLO 320DM)).
View Article and Find Full Text PDFFront Hum Neurosci
December 2024
UMR7020 Laboratoire d'Informatique et Systèmes (LIS), Marseille, France.