83 results match your criteria: "National Cerebral and Cardiovascular Center Hospital.[Affiliation]"

Article Synopsis
  • - Post-stroke complications like epilepsy and cognitive impairment are on the rise due to an aging population, with post-stroke epilepsy making up about half of epilepsy cases in older adults, highlighting the need for effective seizure management.
  • - Research is advancing in areas such as diagnostic techniques and preventative strategies for post-stroke epilepsy while also emphasizing the importance of controlling vascular risk factors to potentially prevent conditions like vascular dementia and Alzheimer's.
  • - The review provides essential clinical information, including diagnostic criteria, classification, risk factors, measurements, and treatment options for managing complications that arise post-stroke.
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[Arrhythmia].

No Shinkei Geka

November 2024

Division of Arrhythmia, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center Hospital.

Article Synopsis
  • The main goals in treating atrial fibrillation (AF) are to prevent strokes using anticoagulants, manage heart rhythm and rate with medications, and explore non-drug therapies like catheter ablation.* -
  • Catheter ablation, which helps improve life quality by addressing AF symptoms, has advanced significantly, with new methods such as balloon ablation and pulsed-field ablation showing fewer complications.* -
  • Surgical methods for treating AF are also becoming less invasive, with innovations like robotic surgery and the Wolf-Ohtsuka procedure, highlighting the need for improved collaboration among heart care teams in future research.*
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Objective: Rupture of cerebral aneurysms has a poor prognosis, and growing aneurysms are prone to rupture. Although the number of coil embolization procedures is increasing worldwide, they are more prone to recurrence than clipping surgeries. However, there is still no drug that prevents aneurysm growth or recanalization after coil embolization.

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Article Synopsis
  • This study evaluated the safety and effectiveness of the Versi Retriever for mechanical thrombectomy in patients suffering from acute ischemic stroke (AIS) at 10 hospitals in Japan.
  • It involved 58 patients, showing that 62% achieved a good recovery (mRS 0-2) after 90 days, and 100% had successful blood flow restoration.
  • The procedure had an 8% mortality rate within 90 days and a significant occurrence of intracranial hemorrhage, indicating that while effective, some risks are involved.
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Aims: This was a retrospective cohort study that aimed to determine cutoff values for major adverse cardiovascular events (MACEs) in patients with heterozygous FH (HeFH) for Achilles tendon (AT) thickness (ATT) measured by ultrasonography (US-ATT) and radiography (Xp-ATT), AT softness, and intima-media thickness of carotid artery (C-IMT), and to examine the effectiveness of these values as well as AT calcification as indexes in assessing risk for MACEs.

Methods: The subjects were 391 clinically diagnosed HeFH patients. Kaplan-Meier curves were drawn based on the threshold values for the individual indexes calculated from ROC curves, and multivariate analysis was used to examine whether they were predictors of the development of MACEs.

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This review outlines the recent advances in stroke and cardiovascular diseases control and direction of national data health reform. Since the enactment of the Basic Act on Countermeasures against Cardiovascular Diseases, the national government and related academic societies have collaborated to promote countermeasures based on five key pillars; medical systems development, registration projects promotion, human resource development, public awareness, and research promotion. Simultaneously, the government is intensively promoting data health reform to compensate for the delay in digital medicine that became evident in the new coronary infection.

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Background: International consensus on cardiopulmonary resuscitation (CPR) and emergency cardiovascular care science and treatment recommendations (CoSTR) have reported updates on CPR maneuvers every 5 years since 2000. However, few national population-based studies have investigated the comprehensive effectiveness of those updates for out-of-hospital cardiac arrest due to shockable rhythms. The primary objective of the present study was to determine whether CPR based on CoSTR 2005 or 2010 was associated with improved outcomes in Japan, as compared with CPR based on Guidelines 2000.

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Introduction: National-level data on trends in the prognosis of age-stratified patients with intracerebral hemorrhage (ICH) are lacking. This study aimed to assess time trends in in-hospital mortality and functional outcomes of ICH patients by sex and age, and to explore factors associated with changes in in-hospital mortality trend.

Patients And Methods: Using the largest nationwide, J-ASPECT stroke database in Japan, this serial cross-sectional study included ICH patients aged ⩾18 years who were hospitalized for non-traumatic ICH from April 2010 to March 2020.

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Objective: To clarify the necessity of acetylsalicylic acid (ASA) administration combined with intravenous immunoglobulin (IVIG) therapy in the treatment of acute Kawasaki disease.

Design: Retrospective cohort study.

Setting: Multicentre.

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Background: Histiocytoid cardiomyopathy is a rare infancy cardiac disorder manifesting as severe cardiac arrhythmias or dilated cardiomyopathy. There is no specific treatment for these arrhythmias. This is the first report of infantile histiocytoid cardiomyopathy whose refractory ventricular arrhythmias were successfully controlled by high-dose carvedilol.

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Background: Intracranial atherosclerotic disease (ICAD) significantly contributes to ischemic stroke, especially among Asian populations. Large vessel occlusion (LVO) due to underlying ICAD accounts for 15-35% of acute ischemic stroke cases requiring endovascular therapy. However, the successful recanalization rate of ICAD-related LVO remains lower.

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Background And Purpose: Various prophylactic drugs for cerebral vasospasm and delayed cerebral infarction (DCI) after subarachnoid hemorrhage (SAH) have been used in Japan. To investigate the treatment trends for cerebral vasospasm and frequency of DCI after SAH throughout Japan in 2021.

Methods: In 2021 we conducted an anonymous questionnaire survey on management for preventing cerebral vasospasm after aneurysmal SAH, and the frequency of DCI.

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Background: Cerebral aneurysms of perforating arteries are rare and can be difficult to detect on computed tomography angiography (CTA) and digital subtraction angiography. Treatment is challenging and associated with a significant risk of morbidity. Endovascular treatment of a thalamoperforating artery (TPA) aneurysm within the midbrain has not previously been reported.

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Craniocervical junction dural arteriovenous fistula and pial arteriovenous fistula are rare cerebrovascular lesions. While their pathophysiology is different, both conditions can cause intracranial hemorrhage attributable to venous congestion. We present, to our knowledge, the first case report of craniocervical junction dural arteriovenous fistula and pial arteriovenous fistula presenting concomitantly in separate locations with subarachnoid hemorrhage.

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Article Synopsis
  • * Despite MRI showing no signs of a tear, dynamic myelography confirmed a leak of contrast medium into the intervertebral disc space.
  • * This situation highlights how incidental dural tears can be missed in endoscopic spine surgeries, making dynamic myelography a valuable tool for assessing these hidden injuries.
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Article Synopsis
  • The study investigated the best duration for dual antiplatelet therapy (DAPT) in patients with cerebral aneurysms after they undergo stent-assisted coil embolization (SACE).
  • Researchers analyzed data from 313 patients, categorizing them into long-term (more than 6 months) and short-term (less than 6 months) DAPT groups.
  • Results showed no significant differences in the incidence of ischemic strokes or hemorrhagic events between the two groups, indicating that the duration of DAPT does not impact these outcomes in the first 15 months post-SACE.
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Article Synopsis
  • This study evaluated trends over six years in the clinical outcomes of patients with subarachnoid hemorrhage (SAH) in Japan, focusing on those treated with either clipping or coiling techniques.
  • It found that in-hospital mortality rates decreased overall, while the percentage of patients undergoing clipping declined, with more patients receiving coiling or remaining untreated.
  • The improvements in Comprehensive Stroke Center capabilities correlated with increased coiling usage but did not affect short-term patient outcomes, indicating a need for further enhancement in care standards.
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Emergency cesarean delivery in patients with heart failure increases maternal and fetal mortality. The present study aimed to identify the relationship between the use of anesthesia for delivery and progressive cardiac deterioration in women with dilated cardiomyopathy (DCM) and to examine its implications on maternal and fetal outcomes. Twenty-nine pregnancies in 25 women with DCM from the National Cerebral and Cardiovascular Center Hospital (Suita, Japan) were included in this retrospective longitudinal study.

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Background: We aimed to estimate the future burden of coronary heart disease (CHD) and stroke mortalities by sex and all 47 prefectures of Japan until 2040 while accounting for effects of age, period, and cohort and integrating them to be at the national level to account for regional differences among prefectures.

Methods: We estimated future CHD and stroke mortality projections, developing Bayesian age-period-cohort (BAPC) models in population and the number of CHD and stroke by age, sex, and all 47 prefectures observed from 1995 to 2019; then applying these to official future population estimates until 2040. The present participants were all men and women aged over 30 years and were residents of Japan.

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Excess deposition of extracellular matrix in the myocardium is a predictor of reduced left ventricular function. Although reducing the hemodynamic load is known to improve myocardial fibrosis, the mechanisms underlying the reversal of the fibrosis have not been elucidated. We focused on the elasticity of myocardial tissue, which is assumed to influence the fibroblast phenotype.

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Candidate gene studies have identified genetic variants associated with clinical outcomes following aneurysmal subarachnoid haemorrhage (aSAH), but no genome-wide association studies have been performed to date. Here we report the results of the discovery phase of a two-stage genome-wide meta-analysis of outcome after aSAH. We identified 157 independent loci harbouring 756 genetic variants associated with outcome after aSAH (p < 1 × 10), which require validation.

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CLICs are the dimorphic protein present in both soluble and membrane fractions. As an integral membrane protein, CLICs potentially possess ion channel activity. However, it is not fully clarified what kinds of roles CLICs play in physiological and pathological conditions.

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Plasma Clearance of Intravenously Infused Adrenomedullin in Rats with Acute Renal Failure.

Biomolecules

September 2022

Department of Hypertension and Nephrology, National Cerebral and Cardiovascular Center Hospital, 6-1 Kishibe-Shimmachi, Suita 564-8565, Osaka, Japan.

Plasma adrenomedullin concentrations are reportedly elevated in patients with renal failure; however, the underlying mechanism is unclear. In this study, we investigated the plasma clearance of synthetic human adrenomedullin (AM) in two models of rats with renal dysfunction; one was induced by subcutaneous injection of mercury chloride (RD-Ag) and the other by completely blocking bilateral renal blood flow (RD-Bl). Sixty minutes after starting intravenous AM infusion, AM levels in RD-Ag, RD-Bl, and rats with normal renal function (NF) were still increased slightly; however, plasma AM levels in RD-Ag rats were approximately three times as high as in RD-Bl and NF rats.

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The impact of gene variants on the thickness and softness of the Achilles tendon in familial hypercholesterolemia.

Atherosclerosis

October 2022

Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan; Cardiovascular Center, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.

Background And Aims: Familial hypercholesterolemia (FH) is characterized by high low-density lipoprotein (LDL)-cholesterol, xanthoma of the Achilles tendon (AT), and premature coronary artery disease (CAD). Ultrasonography can assess AT thickness and softness, making it useful for evaluating AT in FH diagnosis. We aimed to clarify whether FH-causative LDLR or PCSK9 variants affect AT thickness or softness.

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