Effectiveness of the primary Bacillus Calmette-Guérin vaccine against the risk of Mycobacterium tuberculosis infection and tuberculosis disease: a meta-analysis of individual participant data.

Background: Tuberculosis vaccine trials using disease as the primary endpoint are large, time consuming, and expensive. An earlier immunological measure of the protection against disease would accelerate tuberculosis vaccine development. We aimed to assess whether the effectiveness of the Bacillus Calmette-Guérin (BCG) vaccine for prevention of Mycobacterium tuberculosis infection was consistent with that for prevention of tuberculosis disease.

From face-to-face to screen-to-screen: exploring the multifaceted dimensions of digital mental health care.

Background: With the onset of the COVID-19 pandemic, the world witnessed an unprecedented surge in the adoption of digital platforms across various sectors, including mental health care. In countries such as Pakistan, where traditional face-to-face therapy practices hold social and cultural significance, transitioning to digital therapeutic methods presents a range of unique opportunities and challenges.

Objectives: This research aimed to explore the dynamics, implications, and perceptions surrounding digital therapeutic care within the Pakistani sociocultural context.

Close, yet so far away: a phenomenology of the praecox feeling in the diagnosis of schizophrenia as intercorporeal alienness.

Debates concerning the reliability and validity of operationalized criteria and diagnostic tools have surrounded the issue of schizophrenia diagnosis and clinical decision-making related to the disorder. The notion of the praecox feeling (PF) has played a prominent role in the discussions as an example of the possibility of a rapid and potentially valid diagnosis based solely on "intuition" or a peculiar emotional experience or impression arising in a physician during an interaction with a patient with schizophrenia. In this paper, we argue that PF is enabled by the (phenomenologically understood) intercorporeal dimension of the clinical encounter.

Plant extracts as emerging modulators of neuroinflammation and immune receptors in Alzheimer's pathogenesis.

Memory loss is becoming an increasingly significant health problem, largely due to Alzheimer's disease (AD), which disrupts the brain in several ways, including causing inflammation and weakening the body's defenses. This study explores the potential of medicinal plants as a source of novel therapeutic agents for AD. First, we tested various plant extracts against acetylcholinesterase (AChE) , following molecular docking simulations with key AD-related protein targets such as MAO-B, P-gp, GSK-3β, and CD14.

Dynamics of Perceived Stress, Stress Appraisal, and Coping Strategies in an Evolving Educational Landscape.

In the evolving landscape of education, college teachers often find themselves at the crossroads of myriad stressors, ranging from institutional demands to personal challenges. Understanding the factors that influence their stress perceptions and coping mechanisms is pivotal, not just for their well-being, but also for the overall quality of education imparted. This study sought to investigate the intricate relationships between gender, marital status, institutional affiliation, and their collective impacts on perceived stress, stress appraisal, and coping strategies among college teachers.

Bio-based composite from chitosan waste and clay for effective removal of Congo red dye from contaminated water: Experimental studies and theoretical insights.

Water pollution due to dyes in the textile industry is a serious environmental problem. During the finishing stage, Congo red (CR) dye, water-soluble, is released into wastewater, polluting the water body. This study explores the effectiveness of utilizing a composite composed of Safi raw clay and chitosan to remove an anionic dye from synthetic wastewater.

Optimizing prickly pear by-product valorization: formulating molasses with enhanced antioxidant capacities and sugar contents.

This study endeavoured to capitalize on prickly pear by-products for the optimization of molasses formulation, targeting elevated antioxidant capacities and superior sugar contents. Through robust statistical modelling, the optimal cooking parameters-temperature (70-80 °C) and duration (60-90 min)-were determined, guided by responses of antioxidant activity and Brix value. A D-Optimal mixture design further delineated the ideal proportions of molasses components (pulp, peel, and seeds).

Navigating the Shadows of Others' Traumas: An In-Depth Examination of Secondary Traumatic Stress and Psychological Distress among Rescue Professionals.

Rescue workers, who often find themselves on the frontlines of traumatic events, face an increased risk of experiencing secondary traumatic stress (STS) and psychological distress (PD). The nature of their work, alongside professional factors, can influence the way these psychological aspects manifest and their level of severity. This study aimed to explore the relationship between STS and PD in rescue workers.

Epigenetic signature of ionizing radiation in therapy-related AML patients.

Therapy-related acute myeloid leukaemia (t-AML) is a late side effect of previous chemotherapy (ct-AML) and/or radiotherapy (rt-AML) or immunosuppressive treatment. t-AMLs, which account for ∼10-20 % of all AML cases, are extremely aggressive and have a poor prognosis compared to AML. Our hypothesis is that exposure to radiation causes genome-wide epigenetic changes in rt-AML.

Comparison of devices used to measure blood pressure, grip strength and lung function: A randomised cross-over study.

Background: Blood pressure, grip strength and lung function are frequently assessed in longitudinal population studies, but the measurement devices used differ between studies and within studies over time. We aimed to compare measurements ascertained from different commonly used devices.

Methods: We used a randomised cross-over study.

Explicit mechanistic insights of Prosopis juliflora extract in streptozotocin-induced diabetic rats at the molecular level.

Background: The Ancient system of medicine showed the limelight on the use of herbal remedies and was found to possess minimal side effects and acceptable therapeutic outcomes. In this context, Prosopis juliflora gained importance in managing chronic diseases such as cancer, dermatological diseases, and chronic inflammatory disorders. Hence, P.

Exploring the underlying mechanisms of obesity and diabetes and the potential of Traditional Chinese Medicine: an overview of the literature.

Obesity and diabetes are closely related metabolic disorders that have become major public health concerns worldwide. Over the past few decades, numerous studies have explored the underlying mechanisms of these disorders and identified various risk factors, including genetics, lifestyle, and dietary habits. Traditional Chinese Medicine (TCM) has been increasingly recognized for its potential to manage obesity and diabetes.

Evolutionarily diverse origins of deformed wing viruses in western honey bees.

Novel transmission routes can allow infectious diseases to spread, often with devastating consequences. Ectoparasitic varroa mites vector a diversity of RNA viruses, having switched hosts from the eastern to western honey bees ( to ). They provide an opportunity to explore how novel transmission routes shape disease epidemiology.

Low-cost materials as vehicles for pesticides in aquatic media: a review of the current status of different biosorbents employed, optimization by RSM approach.

Water contamination by pesticides is increasing dramatically due to population growth and the extensive use of pesticides in agriculture, leading to grave environmental and health concerns. Thus, efficient processes and the design and development of effective treatment technologies are required due to the enormous demand for fresh water. The adsorption approach has been widely used to remove organic contaminants such as pesticides because of its performance, less expense, high selectivity, and simplicity of operation compared to other treatment technologies.

Baseline levels of integrated biomarker response index (IBR) in Mytilus galloprovincialis (Lamarck, 1819) of BouIsmail bay for monitoring Algerian Bays (Mediterranean Sea).

The Multiple Linear Regression (MLR) technique was used to determine the relationship between the integrated biomarker response index (IBR) with the most important confounding factors (Temperature, pH, Salinity and Dissolved oxygen), in order to define: (1) the baseline assessment criteria (BAC), (2) the environmental assessment criteria (EAC) and (3) the BouIsmail Bay (BIB) -Taxonomy by using Mytilus galloprovincialis sampled from two references sites in BIB (W. Tipaza, Algeria) during one season. Therefore, our results show that, the temperature appeared as a major factor for the explanation of the model.

Modeling integrated biomarker response (IBR) index for the mussel Mytilus galloprovincialis (Lamark 1819) exposed to heavy metal mixture using the CCF design.

Marine pollutants such as heavy metals (HMs) are considered among the most copious oxidative stress (OS) inducers in marine organisms which leads to reactive oxygen species (ROS) formation. Complementary to our previous bioassays studies, the present research focuses on Catalase (CAT), Glutathione S-transferase (GST) and Malondialdehyde (MDA) as oxidative stress biomarkers and the integrated biomarker response (IBR) indexes (IBR and IBR) as an ecotoxicological assessment tool in Mytilus galloprovincialis using central composite face centered (CCF) design. The oxidative stress biomarkers were measured in adult mussels (45-55 mm) on 3 days-exposed under different sub-lethal concentrations of cadmium (Cd), zinc (Zn), and copper (Cu).

Active circulation of varicella zoster virus among different age groups in Sudan.

In Sudan, data on varicella infections are lacking and the vaccine is currently not in use. The aim of this study was to investigate previous exposure to varicella zoster virus (VZV) among children and adults from the general population and among health-care workers (HCWs) in Khartoum. Dried blood spot samples collected between 2015 and 2016 from 294 children aged 1‒15 years, 153 adult volunteers and 241 HCWs were investigated for the presence of VZV IgG antibodies using ELISA.

A surge in obsidian exploitation more than 1.2 million years ago at Simbiro III (Melka Kunture, Upper Awash, Ethiopia).

Pleistocene archaeology records the changing behaviour and capacities of early hominins. These behavioural changes, for example, to stone tools, are commonly linked to environmental constraints. It has been argued that, in earlier times, multiple activities of everyday life were all uniformly conducted at the same spot.

A novel hydrogel beads based copper-doped Cerastoderma edule shells@Alginate biocomposite for highly fungicide sorption from aqueous medium.

The engineering of a novel biocomposite based on Cerastoderma edule shells doped with copper and alginate (Ce-Cu@Alg) forming hydrogel beads was used for batch and dynamic adsorption thiabendazole (TBZ) pesticide from water. The prepared biosorbent was analyzed by various characterization techniques such as scanning electron microscopy (SEM), X-ray diffraction analysis (XRD), Brunauer-Emmett-Teller analysis (BET), and energy dispersive spectroscopy (EDS), thermogravimetric and differential analysis (TGA-DTA). The results of the TBZ batch biosorption by Ce-Cu@Alg composite showed that the Langmuir model was the most adequate to describe the adsorption process, with a maximum adsorption capacity value of 21.

Effects of Pollen Deprivation in Groups of Tellian () and Saharan () Honey Bees under Controlled Conditions.

Worldwide, honey bees are increasingly faced with periods of pollen scarcity, which can lead to nutritional deficiencies, especially of proteins and amino acids. These are essential for the proper functioning of the single organism and the colony. To understand how bees react to protein deficiency, under controlled conditions, we studied the effect of pollen deficiency on the main physiological parameters in two subspecies endemic of Algeria, Apis mellifera intermissa and Apismellifera sahariensis.

Bioactive compounds from and the effect of comosone II on the migration and invasion of breast cancer cells.

Bioassay-guided separation afforded furanodienone 1,10-epoxide () as the new compound, curcolone ( as partially described compound and ten known compounds; germacrone (), furanodienone (, curzerenone ), curcumenol (), zederone (), comosone II (), (1E,4E,8R)-8-hydroxygermacra-1(10),4,7(11)-trieno-12,8-lactone (), 13-hydroxygermacrone (), curcuzederone () and demethoxycurcumin (). The study showed that germacrone, furanodienone, curzerenone, comosone II, 13-hydroxygermacrone, curcuzederone and demethoxycurcumin are the bioactive compounds of rhizomes. Comosone II significantly inhibited MDA-MB-231 cell migration and invasion through the inhibition of MMP-9 enzyme.

Blood meal profile and positivity rate with malaria parasites among different malaria vectors in Sudan.

Background: Malaria is a life-threatening public health problem globally with particularly heavy burden in the sub-Saharan Africa including Sudan. The understanding of feeding preference of malaria vectors on different hosts is a major challenge for hindering the transmission cycle of malaria. In this study, blood meals taken by blood-fed Anopheles mosquitoes collected from the field in malaria endemic areas of Sudan were analysed for source of blood meal and malaria parasite presence.

Study of Structural and Optical Properties of Electrodeposited Silicon Films on Graphite Substrates.

Silicon (Si) films were deposited on low-cost graphite substrates by the electrochemical reduction of silicon dioxide nanoparticles (nano-SiO) in calcium chloride (CaCl), melted at 855 °C. Cyclic voltammetry (CV) was used to analyze the electrochemical reduction mechanism of SiO to form Si deposits on the graphite substrate. X-ray diffraction (XRD) along with Raman and photoluminescence (PL) results show that the crystallinity of the electrodeposited Si-films was improved with an increase of the applied reduction potential during the electrochemical process.