637 results match your criteria: "National Centre for Infectious Diseases[Affiliation]"
Lancet Infect Dis
December 2024
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
J R Soc Interface
December 2024
Centre for the Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, UK.
Directly transmitted infectious diseases spread through social contacts that change over time, but outbreak models typically make simplifying assumptions about network structure and dynamics. To assess how common assumptions relate to real-world interactions, we analysed 11 networks from five settings and developed metrics, capturing crucial epidemiological features of these networks. We developed a novel metric, the 'retention index', to characterize the distribution of retained contacts over consecutive time steps relative to fully static and dynamic networks.
View Article and Find Full Text PDFBackground: Vaccination has been shown to attenuate the risk of post-acute sequelae following SARS-CoV-2 infection. However, no prior population-based studies have evaluated if updated bivalent boosters reduce risk of post-acute sequelae following Omicron-variant infection, versus ancestral vaccines.
Methods: National databases were utilised to construct a population-based cohort of adult individuals infected during Omicron-predominant transmission.
J Paediatr Child Health
November 2024
Neurology Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore.
J Palliat Med
November 2024
Department of Palliative Medicine, Tan Tock Seng Hospital, Singapore, Singapore.
Health Secur
November 2024
Jocelyn J. Herstein, PhD, MPH, is Director, International Partnerships and Programs, NETEC, Nebraska Medicine, and an Assistant Professor, Department of Environmental, Agricultural, and Occupational Health, College of Public Health.
High-level isolation units (HLIUs) are facilities strategically outfitted to receive patients with suspected or confirmed high-consequence infectious diseases (HCIDs). Although most HCID outbreaks occur in low- and middle-income countries, global travel and migration and the deployment of healthcare workers to global outbreaks have led to the occurrence of HCIDs in high-income countries that requires the activation of an HLIU. Despite the existence of HLIUs worldwide, there has been little collaboration between units at the international level.
View Article and Find Full Text PDFChest
November 2024
National Centre for Infectious Diseases, Singapore; Duke-NUS Graduate Medical School, National University of Singapore, Singapore; Ministry of Health, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
JAC Antimicrob Resist
December 2024
Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, USA.
Biomol NMR Assign
November 2024
Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Zika virus has raised global concerns due to its link to microcephaly and Guillain-Barré syndrome in adults. One of viral nonstructural proteins-NS4B, an integral membrane protein, plays crucial roles in viral replication by interacting with both viral and host proteins, rendering it an attractive drug target for antiviral development. We purified the N-terminal region of ZIKV NS4B (NS4B NTD) and reconstituted it into detergent micelles.
View Article and Find Full Text PDFViruses
October 2024
National Centre for Infectious Diseases, Singapore 308442, Singapore.
The ISARIC 4C Mortality score was developed to predict mortality risk among patients with COVID-19. Its performance among vaccinated individuals is understudied. This is a retrospective study of all patients with SARS-CoV-2 infection admitted to the National Centre for Infectious Diseases, Singapore, from January-2020 to December-2021.
View Article and Find Full Text PDFIJTLD Open
October 2024
Sydney Infectious Diseases Institute, The University of Sydney, Sydney, NSW, Australia.
TB is a priority pathogen for the application of whole-genome sequencing (WGS) into routine public health practice. In low-incidence settings, a growing number of services have begun to incorporate routine WGS into standard practice. The increasing availability of real-time genomic information supports a variety of aspects of the public health response, including the detection of drug resistance, monitoring of laboratory and clinical practices, contact tracing investigations and active case finding.
View Article and Find Full Text PDFClin Microbiol Infect
January 2025
National Centre for Infectious Diseases, Singapore, Singapore; Duke-NUS Graduate Medical School, National University of Singapore, Singapore, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Ministry of Health, Singapore, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Open Forum Infect Dis
September 2024
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Background: This systematic review and meta-analysis aimed to analyze the effects of transfusing "nonpacked red blood cell" blood products in patients with dengue and evaluate the effectiveness in reducing mean hospital stay, bleeding, mortality rate, and intensive care unit requirements.
Methods: Four databases were searched for relevant articles. Inclusion criteria were prospective or retrospective randomized or nonrandomized studies investigating the effects of transfusion of blood products in patients with dengue.
Int J Infect Dis
November 2024
Division of Infectious Diseases, Department of Medicine, National University Health System, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:
In subjects with peculiar susceptibility to severe infections by common pyogenic bacteria, mutations of interleukin-1 receptor-associated kinase proteins (IRAK)1 and IRAK4 had been identified. The IRAK kinases function as downstream signal transductors following the activation of pathogen recognition receptors. In two patients with sequential or repeated invasive infections: herpes simplex virus-triggered hemophagocytic lymphohistiocytosis with tuberculosis, and Streptococcus pneumoniae bacteremia with candidemia respectively, novel mutations of IRAK2 were identified.
View Article and Find Full Text PDFVaccine
December 2024
National Centre for Infectious Diseases, Singapore; Duke-NUS Graduate Medical School, National University of Singapore, Singapore; Ministry of Health, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Infect Control Hosp Epidemiol
September 2024
Division of Infectious Diseases, Department of Medicine, National University Hospital, Singapore.
J Hosp Infect
December 2024
National Centre for Infectious Diseases, Singapore, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Health Secur
September 2024
Lauren M. Sauer, MSc, is Associate Director of Research at Global Center for Health Security, Director at Special Pathogens Research Network, and Associate Professor at Department of Environmental, Agricultural and Occupational Health, College of Public Health, University of Nebraska Medical Center, Omaha, NE, USA.
Sex Health
September 2024
National Centre for Infectious Diseases, Singapore, Singapore; and Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Background Structural stigma and institutionalised discrimination towards people living with HIV remain pervasive in many settings. However, qualitative explorations of experiences of stigma, health and social service engagement, and quality of life among people living with HIV in Singapore remain under-researched. Methods Semi-structured interviews were conducted with 73 participants in Singapore.
View Article and Find Full Text PDFVaccine
November 2024
National Centre for Infectious Diseases, Singapore; Tan Tock Seng Hospital, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. Electronic address:
Background: BBV152 (Covaxin™) is a whole-virion inactivated SARS-CoV-2 vaccine mixed with an immune adjuvant. We aimed to compare immune responses after booster vaccination with heterologous BBV152 versus homologous mRNA vaccine.
Methods: We conducted a randomized, participant-blinded, controlled trial.
J Hazard Mater
November 2024
Department of Civil and Environmental Engineering, National University of Singapore, Singapore 117576, Singapore; NUS Environmental Research Institute, National University of Singapore, Singapore 117411, Singapore. Electronic address:
Front Public Health
September 2024
Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou, China.