1 results match your criteria: "National Center of Competence in Research in Molecular Oncology[Affiliation]"
Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism.
Proc Natl Acad Sci U S A
March 2006
Swiss Institute for Experimental Cancer Research, National Center of Competence in Research in Molecular Oncology, 155 Chemin des Boveresses, CH-1066 Epalinges/Lausanne, Switzerland.
Article Synopsis
- Increased Wnt signaling through the expression of Wnt-1 leads to a DNA damage response and tumorigenic changes in primary human mammary epithelial cells.
- Wnt-1-transformed cells show characteristics like high telomerase activity and altered p53 and Rb function, forming tumors in mice that resemble a specific type of breast cancer.
- Notch signaling is also activated in this process and is necessary for maintaining the tumorigenic properties, with correlations found between Wnt and Notch components in human breast carcinomas.