Evaluation of the Anti-Amyloid and Anti-Inflammatory Properties of a Novel Vanadium(IV)-Curcumin Complex in Lipopolysaccharides-Stimulated Primary Rat Neuron-Microglia Mixed Cultures.

Lipopolysaccharides (LPS) are bacterial mediators of neuroinflammation that have been detected in close association with pathological protein aggregations of Alzheimer's disease. LPS induce the release of cytokines by microglia and mediate the upregulation of inducible nitric oxide synthase (iNOS)-a mechanism also associated with amyloidosis. Curcumin is a recognized natural medicine but has extremely low bioavailability.

TH301 Emerges as a Novel Anti-Oncogenic Agent for Human Pancreatic Cancer Cells: The Dispensable Roles of p53, CRY2 and BMAL1 in TH301-Induced /p21 Upregulation.

: Pancreatic Ductal Adeno-Carcinoma (PDAC) is a highly aggressive cancer, with limited treatment options. Disruption of the circadian clock, which regulates key cellular processes, has been implicated in PDAC initiation and progression. Hence, targeting circadian clock components may offer new therapeutic opportunities for the disease.

Similarly to , Is a Positive Regulator of the Humoral Immune Response in the Silkworm, .

Toll receptors play important roles in the development and innate immunity of insects. Previously, we reported the immunological function of in silkworm, , larvae. In this study, we focused on the role of as a regulator in the Toll signaling pathway.

Disentangling Sources of Momentum Fluctuations in Xe+Xe and Pb+Pb Collisions with the ATLAS Detector.

High-energy nuclear collisions create a quark-gluon plasma, whose initial condition and subsequent expansion vary from event to event, impacting the distribution of the eventwise average transverse momentum [P([p_{T}])]. Disentangling the contributions from fluctuations in the nuclear overlap size (geometrical component) and other sources at a fixed size (intrinsic component) remains a challenge. This problem is addressed by measuring the mean, variance, and skewness of P([p_{T}]) in ^{208}Pb+^{208}Pb and ^{129}Xe+^{129}Xe collisions at sqrt[s_{NN}]=5.

Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog.

The emerging field of senolytics is centered on eliminating senescent cells to block their contribution to the progression of age-related diseases, including cancer, and to facilitate healthy aging. Enhancing the selectivity of senolytic treatments toward senescent cells stands to reduce the adverse effects associated with existing senolytic interventions. Taking advantage of lipofuscin accumulation in senescent cells, we describe here the development of a highly efficient senolytic platform consisting of a lipofuscin-binding domain scaffold, which can be conjugated with a senolytic drug via an ester bond.

Gaming Platforms for People with ASD.

Autism spectrum disorder (ASD) has a significant impact on a person's social, emotional, and communication functioning. According to research, individualized instruction can significantly improve these deficits. One of the most successful methods of achieving this outcome is by gaming platforms that provide serious games (SGs).

A subset of human dermal fibroblasts overexpressing Cockayne syndrome group B protein resist UVB radiation-mediated premature senescence.

Ultraviolet B (UVB) radiation is a major contributor to skin photoaging. Although mainly absorbed by the epidermis, UVB photons managing to penetrate the upper dermis affect human dermal fibroblasts (HDFs), leading, among others, to the accumulation of senescent cells. In vitro studies have shown that repeated exposures to subcytotoxic UVB radiation doses provoke HDFs' premature senescence shortly after the end of the treatment period.

Improving Visible Light Photocatalysis Using Optical Defects in CoO-TiO Photonic Crystals.

The rational design of photonic crystal photocatalysts has attracted significant interest in order to improve their light harvesting and photocatalytic performances. In this work, an advanced approach to enhance slow light propagation and visible light photocatalysis is demonstrated for the first time by integrating a planar defect into CoO-TiO inverse opals. Trilayer photonic crystal films were fabricated through the successive deposition of an inverse opal TiO underlayer, a thin titania interlayer, and a photonic top layer, whose visible light activation was implemented through surface modification with CoO nanoscale complexes.

The smartHEALTH European Digital Innovation Hub experiences and challenges for accelerating the transformation of public and private organizations within the innovation ecosystem.

Digital innovation can significantly enhance public health services, environmental sustainability, and social welfare. To this end, the European Digital Innovation Hub (EDIH) initiative was funded by the European Commission and national governments aiming to facilitate the digital transformation on various domains (including health) via the setup of relevant ecosystems consisting of academic institutions, research centres, start-ups, small and medium-sized enterprises, larger companies, public organizations, technology transfer offices, innovation clusters, and financial institutions. The ongoing goal of the EDIHs initiative is to bridge the gap between high-tech research taking place in universities and research centres and its deployment in real-world conditions by fostering innovation ecosystems.

A European aerosol phenomenology - 9: Light absorption properties of carbonaceous aerosol particles across surface Europe.

Carbonaceous aerosols (CA), composed of black carbon (BC) and organic matter (OM), significantly impact the climate. Light absorption properties of CA, particularly of BC and brown carbon (BrC), are crucial due to their contribution to global and regional warming. We present the absorption properties of BC (b) and BrC (b) inferred using Aethalometer data from 44 European sites covering different environments (traffic (TR), urban (UB), suburban (SUB), regional background (RB) and mountain (M)).

Spin coating on a budget: A 3D-Printed all-mechanical alternative for cost-effective thin-film deposition.

Spin coating stands out as the most employed thin-film deposition technique across a variety of scientific fields. Particularly in the past two decades, spin coaters have become increasingly popular due to the emergence of solution-processed semiconductors such as quantum dots and perovskites. However, acquiring commercial spin coaters from reputable suppliers remains a significant financial burden for many laboratories, particularly for smaller research or educational facilities.

Online Measurement for Parameter Discovery in Fused Filament Fabrication.

To describe a new method for the automatic generation of process parameters for fused filament fabrication (FFF) across varying machines and materials. We use an instrumented extruder to fit a function that maps nozzle pressures across varying flow rates and temperatures for a given machine and material configuration. We then develop a method to extract real parameters for flow rate and temperature using relative pressures and temperature offsets.

Search for Soft Unclustered Energy Patterns in Proton-Proton Collisions at 13 TeV.

The first search for soft unclustered energy patterns (SUEPs) is performed using an integrated luminosity of 138  fb^{-1} of proton-proton collision data at sqrt[s]=13  TeV, collected in 2016-2018 by the CMS detector at the LHC. Such SUEPs are predicted by hidden valley models with a new, confining force with a large 't Hooft coupling. In events with boosted topologies, selected by high-threshold hadronic triggers, the multiplicity and sphericity of clustered tracks are used to reject the background from standard model quantum chromodynamics.

Ultrahigh Surface Area Nanoporous Carbons Synthesized via Hypergolic and Activation Reactions for Enhanced CO Capacity and Volumetric Energy Density.

We report a family of carbon sorbents synthesized by integrating hypergolics with activation reactions on a templated substrate. The materials design leads to nanoporous carbons with a BET area of 4800 m g with an impressive total pore volume of 2.7 cm g.

Rectal colonization with multidrug-resistant organisms and risk for bloodstream infection among high-risk Greek patients.

Background: Studies link multidrug-resistant organism (MDRO) rectal colonization to increased infection risk, data from Greece, a country with high rates of MDRO, are limited.

Methods: We assessed bloodstream infection (BSI) risk following rectal colonization by MDROs across three Greek hospitals (2019-2022).

Results: Of 4,370 inpatients, 31.

Source apportionment of ultrafine particles in urban Europe.

There is a body of evidence that ultrafine particles (UFP, those with diameters ≤ 100 nm) might have significant impacts on health. Accordingly, identifying sources of UFP is essential to develop abatement policies. This study focuses on urban Europe, and aims at identifying sources and quantifying their contributions to particle number size distribution (PNSD) using receptor modelling (Positive Matrix Factorization, PMF), and evaluating long-term trends of these source contributions using the non-parametric Theil-Sen's method.

Synthesis and Preclinical Evaluation of a Bispecific PSMA-617/RM2 Heterodimer Targeting Prostate Cancer.

Prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptor (GRPR) have been used for diagnostic molecular imaging/therapy of prostate cancer (PCa). To address tumor heterogeneity, we synthesized and evaluated a bispecific PSMA/GRPR ligand () combining PSMA-617 () and the GRPR antagonist RM2 () with the radiometal chelator DOTA. was radiolabeled with Ga ([Ga]Ga-) and Lu ([Lu]Lu-).

Methods Used in Co-Creation Within the Health CASCADE Co-Creation Database and Gray Literature: Systematic Methods Overview.

Background: Co-creation is increasingly recognized for its potential to generate innovative solutions, particularly in addressing complex and wicked problems in public health. Despite this growing recognition, there are no standards or recommendations for method use in co-creation, leading to confusion and inconsistency. While some studies have examined specific methods, a comprehensive overview is lacking, limiting the collective understanding and ability to make informed decisions about the most appropriate methods for different contexts and research objectives.