4,706 results match your criteria: "National Center for Nanoscience and Technology.[Affiliation]"

A DNAzyme-Based Nanohybrid for Ultrasound and Enzyme Dual-Controlled mRNA Regulation and Combined Tumor Treatment.

Adv Mater

December 2024

Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application, Guangxi Key Laboratory of Regenerative Medicine, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Nanning, 530021, China.

Article Synopsis
  • RNA-cleaving DNAzymes have potential for gene regulation, but their effectiveness and specificity in therapeutic applications are currently limited.
  • A new DNAzyme-based nanohybrid utilizes ultrasound to control the activation of mRNA regulation specifically in tumor cells, combining an enzyme-triggerable DNAzyme with hemoglobin as a sonosensitizer.
  • This approach improves gene regulation by generating reactive oxygen species through ultrasound, leading to better escape from endosomes and enhanced selective treatment of cancer cells, ultimately boosting anti-tumor effects in both lab and live tests.
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Carbon nanotube (CNT) films show great promise as an advanced bulletproof materials due to their excellent energy dissipation ability under impact loadings. However, it is challenging to determine the optimized architecture structure of CNTs to enhance the impact resistance of CNT films. In this study, the impact behavior of CNT films with various architecture structures were studied by micro-ballistic impact experiments and coarse-grained molecular dynamics (CGMD) simulations.

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Spin-Lifetime Probe for Detecting Intramolecular Noncovalent Interaction in Organic Semiconductors.

Adv Mater

December 2024

Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, P. R. China.

Intramolecular noncovalent interaction (INCI), a crucial strategy for effectively enhancing molecular planarity and extending π-electron delocalization in organic semiconductors (OSCs), has played an increasingly important role in optoelectronic applications. However, though the INCI formation is regularly considered to improve the device performance by literature, there is no feasible approach to directly and reliably characterizing its formation in practical-OSC films thus far. Here in this study, by theoretical analysis and calculation, the generation of INCIs in OSCs is found, normally consisting of relatively heavy elements, such as O···Se, O···S, N···S interactions, etc.

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Novel Inorganic-Organic Dual-Photosensitizing Dinuclear-Metal Self-Assembly System for Efficient Artificial Photosynthesis without Sacrificial Electron Donors.

Angew Chem Int Ed Engl

October 2024

Institute for New Energy Materials and Low Carbon Technologies, School of Materials Science & Engineering, Tianjin University of Technology, Tianjin, 300384, P. R. China.

Owing to the unique synergistic effect, dinuclear-metal-molecule-catalysts (DMCs) show excellent performance in catalytic fields. However, for overall photocatalytic CO reaction (CORR), it is still a challenge to construct well-matched photosensitizer (PS) components for DMCs-based photocatalysts. Inorganic-quantum-dot PS possesses capacities of multiple exciton generation and catalyzing water oxidation but is incompatible with DMCs.

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Article Synopsis
  • Using mesenchymal stem cells for skin injury treatment faces challenges like ensuring these cells can effectively integrate and maintain their healing properties.
  • DNA self-assembly techniques can be leveraged to create multifunctional structures on cell surfaces, boosting their therapeutic potential.
  • Engineered stem cells with DNA nanofiber decoration showed improved abilities to scavenge harmful reactive oxygen species, attach to damaged blood vessel cells, and promote new blood vessel formation, making them a promising option for healing wounds in a mouse model.
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Metal-organic frameworks (MOFs) hold significant promise in the realm of gas sensing. However, current understanding of their sensing mechanisms remains limited. Furthermore, the large-scale fabrication of MOFs is hampered by their inadequate mechanical properties.

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Hydrogel-Mediated Jamming of Exosome Communications That Counter Tumor Adaption in the Tumor Immune Microenvironment.

ACS Nano

December 2024

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, New Cornerstone Science Laboratory, National Center for Nanoscience and Technology of China, Beijing 100190, People's Republic of China.

Hypoxia, a common occurrence within solid tumors, can stimulate the dissemination of deceptive tumor exosomes, which function as communicative bridges and orchestrate the recruitment of various supportive cell types for enhanced tumor adaptability in a tumor immune microenvironment. Current nanotechnology provides us intelligent strategies to combat the hypoxic tumor microenvironment. However, once exposed to external stimuli, such as chemotherapy, tumor cells simultaneously release malignant signals to develop tumor migration and immunosuppression, posing challenges to clinical practice.

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Single-molecule electrochemical imaging of 'split waves' in the electrocatalytic (EC') mechanism.

Faraday Discuss

October 2024

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, P. R. China.

We describe a single-molecule electrochemical imaging strategy to study the electrocatalytic (EC') mechanism. Using the fluorescent molecule ATTO647N at extremely low concentrations as the substrate, we confirmed its catalytic reduction to a nonfluorescent form in the presence of the mediator phenazine methosulfate (PMS) by imaging and counting fluorescent molecules. Conventional electrochemical current in cyclic voltammetry would not have allowed us to infer the existence of an EC' process or the PMS-mediated ATTO647N reduction.

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Article Synopsis
  • Neoadjuvant immunochemotherapy (nICT) has significantly impacted the treatment of operable esophageal squamous cell carcinoma (ESCC), though the factors affecting tumor response are still being explored.
  • Single-cell RNA and T cell receptor sequencing showed that a specific type of exhausted CD8 T cells (CXCL13CD8 Tex cells) is prevalent in pre-treatment tumors and is linked to better responses to nICT.
  • The study also identifies immune markers associated with treatment resistance, such as certain fibroblasts and macrophages, suggesting a complex tumor environment that may influence how patients respond to nICT.
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Article Synopsis
  • * Current treatments for female infertility include medications, surgeries, and assisted reproductive technologies, but there are limitations and challenges in translating animal model results to human applications.
  • * Hydrogels present new possibilities for improving female reproductive system repair, offering benefits like biocompatibility and adaptability, while highlighting the need for further research in translational medicine to make these strategies effective.
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In structures with special geometry lattices, variations in stacking sequences are ubiquitous, yielding many novel structures and functionalities. Despite a wealth of intriguing properties and wide-ranging applications, there remains a considerable gap in understanding the correlation between special geometry lattices and functionalities in borides. Here, we design and synthesize a new superconducting boride NbIrB, with a body-centered orthorhombic structure, consisting of alternating two-dimensional [Nb-Ir-Nb] triple-triangular-lattice-layers and B fragment layers.

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Colloidal quantum dots (QDs) are emerging as potential candidates for constructing near-infrared (NIR) photodetectors (PDs) and artificial optoelectronic synapses due to solution processability and a tunable bandgap. However, most of the current NIR QDs-optoelectronic devices are still fabricated using QDs with incorporated harmful heavy metals of lead (Pb) and mercury (Hg), showing potential health and environment risks. In this work, we tailored eco-friendly reverse type-I ZnSe/InP QDs by copper (Cu) doping and extended the photoresponse from the visible to NIR region.

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Tunable hybridized plasmons-phonons in a graphene/mica-nanofilm heterostructure.

Nanoscale

November 2024

CAS Key Laboratory of Nanophotonic Materials and Devices, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, National Center for Nanoscience and Technology, Beijing 100190, P. R. China.

Graphene plasmons exhibit significant potential across diverse fields, including optoelectronics, metamaterials, and biosensing. However, the exposure of all surface atoms in graphene makes it susceptible to surrounding interference, including losses stemming from charged impurity scattering, the dielectric environment, and the substrate roughness. Thus, designing a dielectric environment with a long lifetime and tunability is essential.

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Homologous Peptide Foldamer Promotes FUS Aggregation and Triggers Cancer Cell Death.

J Am Chem Soc

October 2024

CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, 100190 Beijing, China.

Fused in sarcoma (FUS), a multifunctional deoxyribonucleic acid (DNA)/ribonucleic acid (RNA)-binding protein, has been implicated in various cancer types, including sarcoma and leukemia. Despite its association with these diseases, there has been limited exploration of FUS as a cancer therapy target, primarily because its dynamic nature makes it difficult to target specifically. In this study, we explored a kind of β-sheet peptide foldamer, named β-TAT, to influence FUS aggregation by targeting its RNA recognition motifs (RRM).

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Article Synopsis
  • Chiral inorganic nanomaterials (CINMs) are gaining attention for their unique properties that can enhance areas like energy conversion, data storage, catalysis, and biomedicine.
  • Traditional methods for studying CINMs primarily focus on their overall characteristics, but advances in transmission electron microscopy (TEM) are now allowing for detailed structural analysis at the atomic level.
  • This review discusses recent improvements in TEM technologies for analyzing CINMs, highlighting both qualitative and quantitative techniques, and outlines future directions to further advance the understanding and application of chiral nanomaterials.
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Highly efficient organic solar cells enabled by suppressing triplet exciton formation and non-radiative recombination.

Nat Commun

October 2024

College of Materials Science and Opto-Electronic Technology Center of Materials Science and Optoelectronics Engineering CAS Center for Excellence in Topological Quantum Computation CAS Key Laboratory of Vacuum Physics, University of Chinese Academy of Sciences, 100049, Beijing, China.

Article Synopsis
  • * Researchers developed a ternary system using D18:N3-BO:F-BTA3 to reduce the back charge transfer rate and charge-transfer state disorder, resulting in better molecular packing and morphology.
  • * The new system achieved a low non-radiative energy loss of 0.183 eV and a record efficiency of 20.25%, highlighting the importance of managing charge-transfer dynamics in enhancing the performance of organic solar cells.
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Fine-Tuning the d-Band Center Position of Zinc to Increase the Anti-Tumor Activity of Single-Atom Nanozymes.

Adv Mater

November 2024

College of Chemistry & Materials Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding, 071002, P. R. China.

Article Synopsis
  • The research focuses on enhancing the enzymatic activity of Zn-based single-atom nanozymes (SAzymes) for disease treatment by doping them with boron (B), which improves their biocompatibility.
  • By carbonizing a zinc-boron framework at various temperatures, a new form of B-doped Zn-based SAzymes (Zn-SAs@BNC) was created, leading to a modified electron configuration that boosts catalytic activity significantly.
  • The resulting Zn-SAs@BNC demonstrated impressive tumor-killing capabilities, underscoring its potential as an effective strategy for developing efficient anti-tumor therapies.
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Facile synthesis of EGCG modified Au nanoparticles and their inhibitory effects on amyloid protein aggregation.

Int J Biol Macromol

November 2024

CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Center of Materials Science and Optoelectronics Engineering, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100190, China; Sino-Danish College, Sino-Danish Center for Education and Research, University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Article Synopsis
  • Researchers are exploring the use of gold nanoparticles (Au NPs) modified with epigallocatechin-3-gallate (EGCG) to prevent the aggregation of β-amyloid peptides, a key feature in Alzheimer's disease.
  • A straightforward one-step laser ablation process in water was developed to create these modified Au NPs, which have a consistent size and show effectiveness in inhibiting Aβ aggregation through various scientific techniques.
  • The study demonstrates that these Au-EGCG NPs not only prevent Aβ aggregation but also reduce the toxic effects of Aβ on cells, providing a potential new approach for Alzheimer's treatment.
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Enhanced transcytosis and retention (ETR) effect.

Sci Bull (Beijing)

December 2024

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China. Electronic address:

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Understanding droplet wetting on surfaces has broad implications for surface science and engineering. Here, we report a joint theoretical/experimental study of the topological wetting states of water droplets on chemically heterogeneous closed-loop and planar surfaces. Interestingly, we provide both simulation and experimental evidence of biloop or even multiloop transition wetting states of water droplets.

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CsPbIBr perovskite solar cell (PSC) is a promising candidate for high-efficiency single-junction and tandem solar cells. However, due to the numerous surface defects of the CsPbIBr film and the mismatch of energy levels at the CsPbIBr/charge transport layer interface, the power conversion efficiency (PCE) of CsPbIBr PSC is still significantly lower than the theoretical limits. To alleviate those issues, in this work, a carboxylate-based p-type polymer, TTC-Cl, is employed to modify the surface of CsPbIBr layer.

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Publisher Correction: Nitrogen-doped amorphous monolayer carbon.

Nature

October 2024

School of Chemistry, Beijing Advanced Innovation Center for Biomedical Engineering, Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology, Beihang University, Beijing, China.

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Precious metals are valuable materials for the chemical industry, but they are scarce and pose a risk of supply disruption. Recycling precious metals from waste is a promising strategy, here we tactfully utilize light irradiation as an environmental-friendly and energy-saving adjunctive strategy to promote the reduction of precious metal ions, thereby improving the adsorption capacity and kinetics. A newly light-sensitive covalent organic framework (PP-COF) was synthesized to illustrate the effectiveness and feasibility of this light auxiliary strategy.

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Multimodal upconversion and downshifting circularly polarized luminescent materials hold significant potential for optical anticounterfeiting applications due to their exceptional chiroptical properties. However, constructing these materials within a single emitter remains challenging. In this study, a conceptual model of multimodal upconversion/downshifting circularly polarized luminescence (CPL) is realized within a single nanoparticle.

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Picometer-Level In Situ Manipulation of Ferroelectric Polarization in Van der Waals layered InSe.

Adv Mater

November 2024

CAS Key Laboratory of Standardization and Measurement for Nanotechnology, National Center for Nanoscience and Technology, Beijing, 100190, China.

Ferroelectric 2D van der Waals (vdW) layered materials are attracting increasing attention due to their potential applications in next-generation nanoelectronics and in-memory computing with polarization-dependent functionalities. Despite the critical role of polarization in governing ferroelectricity behaviors, its origin and relation with local structures in 2D vdW layered materials have not been fully elucidated so far. Here, intralayer sliding of approximately six degrees within each quadruple-layer of the prototype 2D vdW ferroelectrics InSe is directly observed and manipulated using sub-angstrom resolution imaging and in situ biasing in an aberration-corrected scanning transmission electron microscope.

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