2 results match your criteria: "National Center for Microbiology (CNM - ISCIII)[Affiliation]"
Molecular characterization of gliotoxin synthesis in a biofilm model of .
Biofilm
December 2024
Mycology Reference and Research Laboratory, National Center for Microbiology (CNM-ISCIII), Madrid, Spain.
Mycelial growth as biofilm structures and the activation of secondary metabolism leading to the release of low-molecular-weight molecules (known as secondary metabolites), are among the previously described strategies used by the filamentous fungi to adapt and survive. Our study unveils that strains can activate mechanisms linked to the production of gliotoxin, a crucial metabolite for , in the established biofilm model. Gliotoxin production exhibits strain- and time-dependent patterns and is associated -in a coordinated manner-with the expression levels of several genes involved in its regulation and synthesis.
View Article and Find Full Text PDFDynamics of gliotoxin and bis(methylthio)gliotoxin production during the course of Aspergillus fumigatus infection.
Med Mycol
April 2022
Mycology Reference and Research Laboratory, National Center for Microbiology (CNM - ISCIII), Majadahonda (Madrid), Spain.
Article Synopsis
- Fungal secondary metabolism activates during infections, producing metabolites like gliotoxin and bis(methylthio)gliotoxin, which are important for virulence.
- Researchers optimized production and measurement of these mycotoxins using a specific chromatographic method.
- The study found that gliotoxin appears early in infection, while bis(methylthio)gliotoxin increases as the infection progresses, potentially serving as indicators of infection stages.