9 results match your criteria: "National Center for Leprosy Control[Affiliation]"
Human Adipose-Derived Mesenchymal Stem Cells Colonize and Promote Healing of Leprosy Ulcer by Inducing Neuro-Vascularization.
Stem Cells Dev
June 2024
Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Article Synopsis
- Leprosy ulcers are chronic wounds that result from nerve damage, and existing treatments struggle to promote complete healing and nerve repair, increasing the likelihood of recurring ulcers.
- In this study, human adipose-derived stem cells (hADSCs) were injected into a mouse model of leprosy ulcers, showing promising results in wound healing and nerve regeneration.
- The treatment led to significant improvements in tissue formation, collagen production, and nerve growth, suggesting that hADSCs could be a valuable therapeutic option for managing leprosy ulcers in future clinical settings.
Single-Dose Rifapentine in Household Contacts of Patients with Leprosy.
N Engl J Med
May 2023
From the Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, and the National Center for Leprosy Control, Chinese Center for Disease Control and Prevention (CDC) (L.W., Hongsheng Wang, L.Y., M.Y., H.J., Y.S., W.Z., J.S., X. Yang, H.G., G.Z., B.W.), Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, and Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and Sexually Transmitted Infections (Hongsheng Wang), the Department of Epidemiology and Health Statistics, School of Public Health, Southeast University (X. Yu), and the Department of Epidemiology, School of Public Health, Nanjing Medical University (C.S.), Nanjing, Yunnan Provincial CDC, Kunming (J.Y., L.X., J.H., T.S.), Guizhou Provincial CDC, Guiyang (Jinlan Li, J. Liu, D.W., Y.W.), Hunan Provincial CDC, Changsha (Junhua Li, Y.K., B.L., H.C.), Sichuan Provincial People's Hospital, Chengdu (Y.N., Hao Wang, Y. Liu, X.S.), WenShan Prefecture Institute of Dermatology, Wenshan (H.L.), and Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (B.W.) - all in China.
Background: Previous studies have suggested that a single dose of rifampin has protective effects against leprosy in close contacts of patients with the disease. Rifapentine was shown to have greater bactericidal activity against than rifampin in murine models of leprosy, but data regarding its effectiveness in preventing leprosy are lacking.
Methods: We conducted a cluster-randomized, controlled trial to investigate whether single-dose rifapentine is effective in preventing leprosy in household contacts of patients with leprosy.
Leprosy among new child cases in China: Epidemiological and clinical analysis from 2011 to 2020.
PLoS Negl Trop Dis
February 2023
National Center for Leprosy Control, Chinese Center for Disease Control and Prevention, Hospital for Skin Diseases (Institute of Dermatology), Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu, China.
Background: Leprosy, caused by Mycobacterium leprae infection, mainly affects skin and peripheral nerves and may further lead to disability and deformity if not treated timely. The new case detection rate of leprosy in children reflects the active transmission of leprosy infection. This study aims to present the epidemiology and clinical characteristics of new leprosy cases in children in China from 2011 to 2020.
View Article and Find Full Text PDFSuspicious symptom monitoring for leprosy: an optimal practice for early detection under a low endemic situation in Zhejiang Province, China.
Int J Dermatol
December 2022
Zhejiang Provincial Institute of Dermatology, Huzhou City, Zhejiang Province, P. R. China.
Background: Leprosy is a chronic infectious disease that causes disabilities and deformities. Early detection is a major strategy for leprosy control. This study reported a new practice of suspicious symptom monitoring for early detection of leprosy.
View Article and Find Full Text PDFTowards a Leprosy-Free Country - China, 2011-2018.
China CDC Wkly
January 2020
Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College & National Center for Leprosy Control, Chinese Center for Disease Control and Prevention, Nanjing, China.
Leprosy is a chronic infectious disease that is endemic in several countries. Control of leprosy has had targets set by World Health Organization's (WHO) Global Strategy 2016-2020 and by China through a national leprosy-control plan (2011-2020). Data from the Leprosy Management Information System in China was analyzed and showed a national prevalence of 0.
View Article and Find Full Text PDFA study on gender differences in newly detected leprosy cases in Sichuan, China, 2000-2015.
Int J Dermatol
December 2018
Institute of Dermatology and Venereology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China.
Background: Many researches on gender differences in leprosy found that female patients were detected with the disease later and had more serious disabilities than male patients. We analyzed the gender differences related to epidemiological characteristics of new leprosy cases detected from 2000 to 2015 in Sichuan Province, China.
Methods: A retrospective study was undertaken to analyze the gender differences with respect to age, delay in disease detection, the main modes of detection, and disability grade.
Features of leprosy transmission in pocket villages at low endemic situation in China.
Indian J Lepr
April 2011
Department of Leprosy Control, Institute of Dermatology, Chinese Academy of Medical Sciences, National Center for Leprosy Control, China.
To study the characteristics of leprosy transmission at low endemic situation and to analyze the reason why transmission still existed. A retrospective study was carried out on transmission of leprosy in thirteen leprosy high endemic villages in Wenshan district, Yunnan Province, China. A special questionnaire was designed for collecting the data.
View Article and Find Full Text PDFCauses of death among active leprosy patients in China.
Int J Dermatol
January 2011
Department for Leprosy Control, National Center for Leprosy Control, Chinese Academy of Medical Sciences, Nanjing, Jiangsu, China.
We analyzed the causes of death among active leprosy patients in China, to better understand the disease and improve the quality of services, by performing a retrospective study involving 24 provinces of China. Information about patients with active leprosy who were not clinically cured and died between January 1, 2000, and December 31, 2005, was collected by professionals at county levels. A total of 524 deaths were analyzed.
View Article and Find Full Text PDF[Epidemiological analysis on leprosy in China, 2009].
Zhonghua Liu Xing Bing Xue Za Zhi
October 2010
Institute of Dermatology, Chinese Academy of Medical Science, National Center for Leprosy Control, Chinese Center for Disease Control and Prevention, Nanjing 210042, China.
Objective: To study the epidemiological characteristics of leprosy and to provide evidence for specific strategies development on leprosy control.
Methods: Descriptive analysis of data from the national leprosy surveillance system was carried out in 2009.
Results: A total number of 1597 new cases were detected in 2009 with a case detection rate of 0.