3 results match your criteria: "National Center for Environmental Assessment. Cincinnati[Affiliation]"
Epigenetic Regulation in Environmental Chemical Carcinogenesis and its Applicability in Human Health Risk Assessment.
Int J Toxicol
July 2016
U.S. Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment. Cincinnati, OH, USA
Article Synopsis
- Several studies indicate that chemical-induced epigenetic changes, like DNA methylation, may play a role in various diseases, but their use in assessing human health risks is not clearly defined.
- The study explores the connection between cancer incidence and DNA methylation changes in lab animals exposed to specific environmental toxicants, revealing that the points of departure (PODs) for both are closely related.
- Findings suggest that DNA methylation may be a more sensitive indicator than cancer incidence, especially regarding DEHP exposure at different life stages, and that it could serve as a valuable screening tool for assessing the toxicity of various chemicals.
Generic assessment endpoints are needed for ecological risk assessment.
Risk Anal
April 2000
National Center for Environmental Assessment-Cincinnati, U.S. Environmental Protection Agency, OH 45268, USA.
This article presents arguments for the development of generic assessment endpoints for ecological risk assessment. Generic assessment endpoints would be ecological entities and attributes that are assumed to be worthy of protection in most contexts. The existence of generic assessment endpoints would neither create a requirement that they be used in every assessment nor preclude the use of other assessment endpoints.
View Article and Find Full Text PDFUse of genetic toxicology data in U.S. EPA risk assessment: the mercury study report as an example.
Environ Health Perspect
May 1996
National Center for Environmental Assessment-Cincinnati, U.S. Environmental Protection Agency, Ohio 45268, USA.
Assessment of human health risks of environmental agents has often been limited to consideration of the potential for the agent to cause cancer or general systemic toxicity after long-term exposure. The U.S.
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