Licochalcone A specifically induces cell death in glioma stem cells via mitochondrial dysfunction.

Glioblastoma multiforme is the most malignant primary intrinsic brain tumor. Glioma stem cells (GSCs) are associated with chemoradiotherapy resistance and the recurrence of glioblastomas after conventional therapy. The targeting of GSCs is potentially an effective treatment for the long-term survival of glioblastoma patients.

Does postoperative morbidity worsen the oncological outcome after radical surgery for gastrointestinal cancers? A systematic review of the literature.

Purpose: The impact of postoperative complications on survival after radical surgery for esophageal, gastric, and colorectal cancers remains controversial. We conducted a systematic review of recent publications to examine the effect of postoperative complications on oncological outcome.

Methods: A literature search of PubMed/MEDLINE was performed using the keywords "esophageal cancer," "gastric cancer," and "colorectal cancer," obtaining 27 reports published online up until the end of April 2016.

Brain metastases in gastro-oesophageal adenocarcinoma: insights into the role of the human epidermal growth factor receptor 2 (HER2).

Background: Gastro-oesophageal adenocarcinomas rarely metastasize to the central nervous system (CNS). The role of the human epidermal growth factor receptor 2 (HER2) in patients with these cancers and CNS involvement is presently unknown.

Patients And Methods: A multicentre registry was established to collect data from patients with gastro-oesophageal adenocarcinomas and CNS involvement both retrospectively and prospectively.

Latest insights into the risk of cancer in diabetes.

A growing body of evidence from observational studies and meta-analyses of the data suggest that diabetes mellitus is associated with an increased risk of cancer. Meta-analyses have shown that diabetes increases the risks of total cancer, and of site-specific cancers of the breast, endometrium, bladder, liver, colorectum and pancreas, and that it decreases the risk of prostate cancer. Insulin resistance and secondary hyperinsulinemia is the most frequently proposed hypothesis, and hyperglycemia itself might promote carcinogenesis.

Clinical characteristics and outcomes of women with stage IV endometrial cancer.

Treatment strategies for patients with stage IV endometrial cancer (EC) remain controversial. Some studies have suggested that optimal cytoreduction improves survival. We retrospectively analyzed the clinical characteristics and outcomes of 41 women with stage IV EC.

Preoperative evaluation of invasive and noninvasive intraductal papillary-mucinous neoplasms of the pancreas: clinical, radiological, and pathological analysis of 123 cases.

Objective: We aimed to investigate preoperative findings that are useful to distinguish intraductal papillary-mucinous neoplasm (IPMN) subtypes.

Methods: One hundred twenty-three patients who underwent pancreatectomy for IPMN were analyzed clinicopathologically and radiologically. Invasive IPM carcinomas (IPMCs) were subdivided into early-stage nonaggressive (minimally invasive IPMC [MI-IPMC]) and more advanced and aggressive (invasive carcinoma originating in IPMC [IC-IPMC]) subtypes according to our recently proposed pathological criteria.

[Practice guidelines for lung cancer invading the neighboring anatomic structures].

Lung cancers invading the neighboring anatomic structures such as the chest wall, diaphragm, great vessels (superior vena cava, aorta, left atrium, etc.), and tracheal carina are categorized as T3 or T4, and are regarded as locally advanced lung cancer. The surgical indications mode of resection, and combined treatment for these tumors have been important issues.

A VATS lobectomy for lung cancer in a patient with an anomalous pulmonary vein: report of a case.

A video-assisted right upper lobectomy was successfully performed on a 58-year-old man with an anomalous segmental pulmonary vein. The tumor was a peripherally located adenocarcinoma. The anomalous vein behind the right main bronchus was identified and safely divided.

[The techniques to protect the anastomotic leakage of esophagogastrostomy at the neck].

This paper described the techniques to protect the leakage of anastomosis in esophagogastrostomy at the neck. The cautious techniques to protect anastomotic leakage is; 1) When there are not the connection between right gastroepiploic vessel with left gastroepiploic vessel, it is better that the amount of large omentum shall be reserved as possible as. 2) It is important that for the preservation of blood circulation at the submucosa of anastomosis, the intestinal clamp do not be applicated.