5 results match your criteria: "National Cancer Center EPOC[Affiliation]"
Eldecalcitol for sarcopenia prevention in adults with prediabetes - Authors' reply.
Lancet Healthy Longev
June 2024
Division of Cancer Immunotherapy, National Cancer Center EPOC, Kashiwa, Japan.
Active vitamin D treatment in the prevention of sarcopenia in adults with prediabetes (DPVD ancillary study): a randomised controlled trial.
Lancet Healthy Longev
April 2024
The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Article Synopsis
- A study investigated whether treatment with active vitamin D (eldecalcitol) could lower the risk of developing sarcopenia in adults with prediabetes, given previous observational findings suggesting a connection between vitamin D levels and sarcopenia.
- The research was a randomized, double-blind, placebo-controlled trial involving 1,094 participants across 32 sites in Japan, measuring sarcopenia incidence over three years.
- Results showed that those treated with eldecalcitol had a significantly lower incidence of sarcopenia compared to the placebo group, with no notable difference in adverse events, indicating potential benefits of vitamin D treatment for muscle health.
Correlation of Vein-Rich Tumor Microenvironment of Intrahepatic Cholangiocarcinoma With Tertiary Lymphoid Structures and Patient Outcome.
Mod Pathol
February 2024
Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan; Division of Innovative Pathology and Laboratory Medicine, National Cancer Center EPOC, Tokyo, Japan. Electronic address:
Intrahepatic cholangiocarcinoma (iCCA) is an aggressive cancer composed of large-duct and small-duct types. Understanding the tumor immune microenvironment and its related vascular system is important for developing novel and efficient therapies. We focused on tertiary lymphoid structure (TLS) as a hallmark of antitumor immunity and investigated the clinicopathologic significance of TLSs and the influence of vascular microenvironment on TLS formation in iCCAs.
View Article and Find Full Text PDFNovel Insights Into Immunohistochemical Analysis For Acinar Cell Neoplasm of The Pancreas: Carboxypeptidase A2, Carboxypeptidase A1, and Glycoprotein 2.
Am J Surg Pathol
May 2023
Division of Molecular Pathology.
Acinar cell carcinoma (ACC) is a rare and highly malignant pancreatic tumor. Owing to histologic similarity, ACC is often difficult to distinguish from other solid medullary pancreatic tumors, particularly neuroendocrine neoplasm (NEN) and intraductal tubulopapillary neoplasm (ITPN). We aimed to identify new immunohistochemical markers commonly expressed in tumor cells with acinar cell differentiation and useful for both surgical and small biopsy specimens.
View Article and Find Full Text PDFObjective: To assess whether eldecalcitol, an active vitamin D analogue, can reduce the development of type 2 diabetes among adults with impaired glucose tolerance.
Design: Double blinded, multicentre, randomised, placebo controlled trial.
Setting: Three hospitals in Japan, between June 2013 and August 2019.