994 results match your criteria: "National Addiction Centre.[Affiliation]"

Introduction: Rural regions generally report higher smoking rates than urban centers, which increases the risk of tobacco related harms and consequences, and makes promoting smoking cessation in these areas a priority. Mass distribution of nicotine replacement therapy (NRT) by postal mail has been found to increase the odds of successful cessation attempts. Understanding factors that contribute to the use of NRT could help maximize this intervention's effectiveness.

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The safety and efficacy of cannabinoids for the treatment of mental health and substance use disorders: protocol for a systematic review and meta-analysis.

Syst Rev

January 2025

The Matilda Centre for Research in Mental Health and Substance Use, Level 6 Jane Foss Russell Building, The University of Sydney, Camperdown, NSW, 2006, Australia.

There has been a global increase in the use of cannabinoids as a treatment for mental health (MH) and substance use disorders (SUD). In 2016, an Australian government-funded review found that although medicinal cannabinoids accounted for a small reduction in MH symptoms, the results varied according to study design. There has since been a rise in randomised controlled trials (RCTs) aiming to examine the efficacy of cannabinoids for the treatment of MH and SUD.

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Sexualised drug use (SDU) is a highly prevalent phenomenon of increasing public health significance in communities of men who have sex with men (MSM). This prospectively registered PRISMA-ScR-adherent systematic scoping review examines the current state of knowledge surrounding violence amongst MSM in the context of SDU. A broad search was conducted across four databases, with no restrictions.

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: Cannabidiol (CBD) is an approved treatment for childhood epilepsies and a candidate treatment for several other CNS disorders. However, it has poor oral bioavailability. We investigated the effect of a novel lipid formulation on its absorption in humans and on its tissue distribution in mice.

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Background: Exposure to illicit substances during pregnancy may have long-term impacts on children's neurodevelopment. This study explores subsequent risks for intellectual disability, autistic disorders, and attention deficit and hyperactivity disorders in children born to mothers exposed to illicit substances before or during pregnancy.

Methods: We identified women with illicit drug use by linking the police records from the "Substance Abuse Control Databases" and Taiwan Birth Registration and Birth Notification records from 2004 to 2014.

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Background: The therapeutic alliance is an important predictor of treatment outcomes but people who use alcohol and other drugs report mixed views of treatment providers. We analysed patients' accounts of inpatient detoxification staff to ascertain whether, and if so how, relationships with them, and thus the therapeutic alliance, might be improved.

Methods: Semi-structured qualitative interviews were conducted (in 2022/2023) with 20 people (14 males; 6 females) who had just completed inpatient detoxification in sixteen different facilities.

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Article Synopsis
  • This study analyzed data from 3,906 adults (ages 18+) across Canada, the US, England, and Australia to investigate the prevalence and causes of negative side effects from nicotine vaping products (NVPs).
  • Results showed that 87.1% of participants reported no negative effects, with the most common issues being throat irritation, cough, and mouth irritation, and only a small percentage sought medical advice.
  • Factors linked to higher reports of side effects included being younger, still smoking, vaping for less than six months, and using nicotine or certain flavors like menthol/mint while vaping.
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Does perceived vaping addiction predict subsequent vaping cessation behaviour among adults who use nicotine vaping products regularly?

Addict Behav

January 2025

Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. Electronic address:

Background: This study aimed to investigate whether perceived vaping addiction is a predictor of quitting nicotine vaping product (NVP) use among adults who have ever smoked and currently vape exclusively or predominantly in four countries: Australia, Canada, the US, and England.

Method: Data analysed (n = 574) came from participants (aged 18 + ) who completed the International Tobacco Control (ITC) Four Country Smoking and Vaping survey in 2018 and again in 2020. Baseline inclusion criteria were: (1) currently not smoking or non-daily smoking; and (2) using NVPs daily/weekly for a period of at least 4 months.

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Background: Quitting smoking is difficult and many people who smoke experience cessation fatigue (CF) as a result of multiple failed attempts. This study examined the association of CF with making and sustaining a smoking quit attempt.

Methods: Data analysed were 4,139 adults (aged 18 years or older) who smoked daily or weekly and participated in the 2018 and 2020 International Tobacco Control Four Country Smoking and Vaping Surveys (ITC 4CV) conducted in Australia, Canada, England, and the US.

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Article Synopsis
  • A study analyzed drug-related fatalities in the UK where individuals were found submerged in baths or hot tubs between 1997 and 2023, identifying case characteristics and drugs involved.* -
  • Of 162 deaths, the majority of victims were middle-aged white males, with an average of three drugs detected in each case; heroin, alcohol, and cocaine were the most common substances.* -
  • The results indicate a consistent annual occurrence of these fatalities, suggesting the need for public health campaigns advising against bathing while under the influence of drugs or alcohol.*
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Background: Opioid overdose is a global health crisis, affecting over 27 million individuals worldwide, with more than 100,000 drug overdose deaths in the United States in 2022-2023. This protocol outlines the development of the PneumoWave chest biosensor, a wearable device being designed to detect respiratory depression in real time through chest motion measurement, intending to enhance early intervention and thereby reduce fatalities.

Objective: The study aims to (1) differentiate opioid-induced respiratory depression (OIRD) from nonfatal opioid use patterns to develop and refine an overdose detection algorithm and (2) examine participants' acceptability of the chest biosensor.

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Integrated Motivational Strategies for Intimate Partner Violence Perpetrators with Substance Use: A Randomized Controlled Trial.

Psychosoc Interv

September 2024

University of Valencia Faculty of Psychology and Speech Therapy Department of Social Psychology Spain Department of Social Psychology, Faculty of Psychology and Speech Therapy, University of Valencia, Spain.

Intimate partner violence (IPV) perpetrators with alcohol and/or other drug use problems (ADUPs) have been identified as one of the main high-risk and highly resistant groups of perpetrators requiring special attention in intervention programs for IPV perpetrators. This randomized controlled trial (RCT) aimed to evaluate whether an individualized motivational plan adjusted to ADUPs (IMP-ADUPs) was superior to standard motivational strategies (IMP) in reducing ADUPs, and IPV and increasing treatment adherence in IPV perpetrators. Data from a full sample of IPV perpetrators ( = 140) and a subsample of participants with ADUPs ( = 55) were collected at pre- and post-intervention and 12-month follow-up.

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Long-acting injectable buprenorphine (LAIB) is a new treatment for opioid use disorder. Drawing upon new materialism and the concept of social capital, this article provides a focused analysis of how LAIB affects, and is affected by, patients' relationships with other people. Data derive from a longitudinal qualitative study.

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Sexualized drug use (SDU) describes drug-facilitated sexual enhancement, and chemsex is an SDU subculture involving the use of specific drugs by men who have sex with men (MSM). This study aimed to identify research trends, foci, and themes within the SDU and chemsex-specific literature. The Web of Science Core Collection was searched with a list of SDU synonyms.

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Aims: To measure changes over time (between 2017 and 2023) in disposable e-cigarette use and popular brands among youth in Canada, England and the United States (US) who vaped.

Design: Nine waves of repeat cross-sectional data from the International Tobacco Control Policy Evaluation Project (ITC) Youth Tobacco and Vaping Survey.

Setting: Online surveys conducted in Canada, England and the US between 2017 and 2023.

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The Pharmacological Management of Ketamine Use Disorder: A Systematic Review.

J Addict Med

October 2024

From the National Addiction Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, United Kingdom and South London, and the Maudsley NHS Foundation Trust, United Kingdom (ER); and South London and the Maudsley NHS Foundation Trust, United Kingdom (ES, IG).

Objectives: There has been limited evidence synthesis examining treatment of ketamine use disorder. We aimed to conduct a systematic review to assess the efficacy and tolerability of pharmacological interventions in the management of ketamine use disorder.

Methods: We searched MEDLINE, EMBASE, PsychINFO, and CENTRAL (Cochrane Central Register of Controlled Trials) from database inception to November 14, 2023, for studies of any design that reported on any pharmacological intervention in the management of ketamine use disorder.

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Vaping during pregnancy: a systematic review of health outcomes.

BMC Pregnancy Childbirth

June 2024

National Addiction Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, SE5 8BB, UK.

Introduction: Smoking during pregnancy is harmful to maternal and child health. Vaping is used for smoking cessation but evidence on health effects during pregnancy is scarce. We conducted a systematic review of health outcomes of vaping during pregnancy.

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Background: Many people continue to smoke despite strong policies to deter use, thus stronger regulatory measures may be required. In four high-income countries, we examined whether people who smoke would support a total ban on smoked tobacco products under two differing policy scenarios.

Methods: Data were from 14 363 adults (≥18) who smoked cigarettes (≥monthly) and participated in at least one of the 2018, 2020 or 2022 International Tobacco Control Four Country Smoking and Vaping Surveys in Australia, Canada, England and the USA.

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'Matters-of-concern' associated with discontinuation of long-acting injectable buprenorphine: Findings from a longitudinal qualitative study.

Int J Drug Policy

July 2024

National Addiction Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, SE5 8BB, UK; South London & Maudsley (SLaM) NHS Foundation Trust, London SE5 8AZ, UK.

Article Synopsis
  • Discontinuation of long-acting injectable buprenorphine (LAIB) among patients in opioid agonist treatment is a complex issue influenced by various factors, including both provider decisions and patient choices.
  • A longitudinal qualitative study consisting of 44 interviews with 8 participants revealed that factors like late appointments, substance use, personal circumstances, and treatment side effects significantly contribute to prescription discontinuation.
  • The findings highlight that opioid agonist treatment is not a one-size-fits-all solution; it evolves based on individual experiences and motivations, indicating a need for flexible treatment approaches.
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Background And Aims: Vaping products are diverse with a wide variety of features, and popular products change rapidly. This study examined the features and types of vaping products that people who smoke and/or vape perceive contribute to the health harms of vaping.

Design, Setting And Participants: This was a cross-sectional survey co-designed with adults who smoked/vaped and pre-registered.

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Introduction: This study examined menthol cigarette use among youth who smoked, after menthol cigarette bans were implemented in England (May 2020) and Canada (October 2017).

Aims And Methods: Cross-sectional data come from 2021 ITC Youth Tobacco and Vaping Survey respondents aged 16-19 who smoked in the past 30 d in England (N = 715) and Canada (N = 419). Adjusted logistic regression models, estimated separately for each country, examined sociodemographic correlates of usually smoking menthol cigarettes (reporting currently most often smoking menthol cigarettes) overall, and by past 30-d use of any menthol accessories (e.

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