2 results match your criteria: "National Abdominal Surgery Institute of Fujian[Affiliation]"
Hypoglycemic mechanism of intestinal bypass surgery in type 2 diabetic rats.
Sci Rep
November 2021
Hepatopancreatobiliary Surgery Department, The First Affiliated Hospital of Fujian Medical University, National Abdominal Surgery Institute of Fujian, No 20 Chazhong Road, Fuzhou City, Fujian, People's Republic of China.
To investigate the effect of duodenal-jejunal bypass (DJB) surgery on postoperative blood glucose in type 2 diabetic rats, and further explore possible mechanisms for the effect of surgical treatment of type 2 diabetes. Forty rats with type 2 diabetes were randomly assigned to 4 groups (n = 10 rats per group), which subsequently underwent DJB, new biliopancreatic diversion (NBPD) or duodenal-jejunal exclusion (DJE) surgery or a sham operation (SHAM). Fasting glucose, 2-h postprandial glucose and blood lipids were measured, and the mRNA in liver and intestinal tissue for bile acid receptor (FXR), as well as the FXR protein expression in the liver tissues were determined.
View Article and Find Full Text PDFEffects of different foods on blood glucose and lipid in type 2 diabetes mellitus in a rat model.
J Surg Res
September 2018
Hepatopancreatobiliary Surgery Department, the First Affiliated Hospital of Fujian Medical University, National Abdominal Surgery Institute of Fujian, Fuzhou City, Fujian, PR China. Electronic address:
Background: This study investigated the effects of duodenal-jejunal bypass (DJB) and new biliopancreatic diversion (NBPD) on blood glucose and lipid levels in type 2 diabetes mellitus (T2DM). An additional goal was to explore the potential mechanism or mechanisms underlying the therapeutic effects of surgery on T2DM.
Methods: Rats were fed a high-fat, high-glucose diet and then were intraperitoneally injected with streptozotocin, 35 mg/kg, to induce T2DM.