1 results match your criteria: "Naqu People's Hospital of the Tibet Autonomous Region[Affiliation]"
Hif-1α expression targets the TMA/Fmo3/TMAO axis to participate in gallbladder cholesterol stone formation in individuals living in plateau regions.
Biochim Biophys Acta Mol Basis Dis
June 2024
Department of General Surgery, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China; Department of General Surgery, Naqu People's Hospital of the Tibet Autonomous Region, Naqu, Tibet, PR China. Electronic address:
The incidence of gallbladder cholesterol stones (GCS) increases rapidly among people living in high-altitude hypoxic environments compared to those in normoxic areas. Upregulation of hepatic hypoxia inducible factor 1α (Hif-1α) plays a key role in the formation of GCS. High plasma trimethylamine-N-oxide (TMAO) levels are positively correlated with the occurrence of GCS.
View Article and Find Full Text PDF