2 results match your criteria: "Nantz National Alzheimer Center and Houston Methodist Research Neurological Institute[Affiliation]"
Parametric Mapping for TSPO PET Imaging with Spectral Analysis Impulsive Response Function.
Mol Imaging Biol
August 2021
Nantz National Alzheimer Center and Houston Methodist Research Neurological Institute, and Weill Cornell Medicine, 6670 Bertner Ave, Houston, TX, 77030, USA.
Purpose: The aim of this study was to investigate the use of spectral analysis (SA) for voxel-wise analysis of TSPO PET imaging studies. TSPO PET quantification is methodologically complicated by the heterogeneity of TSPO expression and its cell-dependent modulation during neuroinflammatory response. Compartmental models to account for this complexity exist, but they are unreliable at the high noise typical of voxel data.
View Article and Find Full Text PDFHead-to-head comparison of C-PBR28 and C-ER176 for quantification of the translocator protein in the human brain.
Eur J Nucl Med Mol Imaging
August 2019
Nantz National Alzheimer Center and Houston Methodist Research Neurological Institute, and Weill Cornell Medicine, 6670 Bertner Ave, Houston, TX, 77030, USA.
Introduction: C-ER176 is a new PET tracer to quantify the translocator protein (TSPO), a biomarker for inflammation. The aim of this study was to perform a head-to-head comparison between C-ER176 and the widely used C-PBR28.
Methods: Seven healthy volunteers had a 90-min PET scan and metabolite-corrected arterial input function with C-PBR28 in the morning and C-ER176 in the afternoon.