Graphene oxide with in-situ grown Prussian Blue as an electrochemical probe for microRNA-122.

An electrochemical biosensor for microRNA was constructed on the basis of direct growth of electroactive Prussian Blue (PB) on graphene oxide (GO). A mercapto-modified probe DNA that is complementary to the hepatocellular carcinoma biomarker microRNA-122 was firstly anchored on a gold electrode (AuE). Then, GO (with its large surface and multiple active sites) was adsorbed on probe DNA through π-interaction.

High-performance non-enzymatic glucose sensor by hierarchical flower-like nickel(II)-based MOF/carbon nanotubes composite.

A hierarchical three-dimensional flower-like nickel(II)-terephthalic acid (Ni(TPA)) metal-organic framework (MOF) was synthesized through a simple solvothermal method. Then the single-walled carbon nanotubes (SWCNT) were doped with the synthesized Ni(TPA) MOF by the ultrasonic method to improve the chemical stability and the electrochemical activity of the MOF. To explore the potential application of the nanocomposite, the Ni(TPA)-SWCNT modified glassy carbon electrode was prepared and used as a non-enzymatic electrochemical sensor for glucose.

Hsa_circ_0014717 is downregulated in colorectal cancer and inhibits tumor growth by promoting p16 expression.

Circular RNAs (circRNAs) represent a novel class of non-coding RNAs that may regulate gene expression in eukaryotes. Nevertheless, their potential functions in human malignancies are still largely unknown. The aim of this study was to explore the expression of hsa_circ_0014717 in colorectal cancer (CRC) and its role involving in tumor growth.

Diagnostic and prognostic potential of serum miR-132/212 cluster in patients with hepatocellular carcinoma.

Background It has been reported that both of the miR-132/212 (micro-RNA) cluster members, miR-132 and miR-212, are downregulated in hepatocellular carcinoma. Nevertheless, the expression pattern and clinical utility of serum miR-132/212 in hepatocellular carcinoma are still unknown. Methods In this study, serum concentrations of miR-132 and miR-212 were measured in 80 hepatocellular carcinoma patients, 51 controls with chronic liver diseases and 42 healthy volunteers by using quantitative real-time polymerase chain reaction.

miR-493-5p suppresses hepatocellular carcinoma cell proliferation through targeting GP73.

Aberrant expression of miRNAs has been documented to play critical roles in the development and progression of hepatocellular carcinoma (HCC). However, the expression pattern, functional roles and regulatory mechanism of miR-493-5p in HCC have not been addressed. Herein, we found that miR-493-5p was significantly downregulated in HCC tissues and was tightly associated with tumor size, tumor differentiation grade and TNM stage of HCC patients.