4 results match your criteria: "Nanning Social Welfare Hospital.[Affiliation]"
Causal effects of gut microbiota on gout and hyperuricemia: insights from genome-wide Mendelian randomization, RNA-sequencing, 16S rRNA sequencing, and metabolomes.
Biosci Rep
November 2024
Medical College, Guangxi University, Nanning 530004, China.
Article Synopsis
- This study explored how gut microbiota (GM) affects the development of gout and hyperuricemia using genetic data and experiments on mice.
- Researchers used advanced statistical methods to predict the impact of GM on gout and identified specific GM taxa linked to the disease, as well as 38 immune cell traits associated with gout.
- The findings revealed that changes in gut microbiome due to dysbiosis were related to alterations in serum metabolites and kidney gene expression, affecting vitamin B6 metabolism and leading to inflammation.
Leech protein extract ameliorated hyperuricemia by restoring gut microbiota dysregulation and affecting serum metabolites.
World J Gastroenterol
August 2024
Medical College, Guangxi University, Nanning 530004, Guangxi Zhuang Autonomous Region, China.
Article Synopsis
- Hyperuricemia (HUA) is an urgent public health issue, and research shows that a certain lyophilized powder can significantly reduce its symptoms, though how it works metabolically is still unclear.
- The study involved creating a rapid HUA mouse model and analyzing the effects of the powder through various biochemical methods, revealing nine specific bacterial genera and 22 metabolites linked to its anti-HUA activity.
- The findings suggest that the powder's proteins effectively combat HUA by improving gut microbiota balance and regulating key metabolic pathways.
Flavonoid compounds are a group of polyphenolic molecules that are in vegetables, fruit, and grain. Laboratory studies and epidemiological investigations have indicated diverse beneficial biochemical properties of flavonoids, including anticancer, anti-inflammation, anti-oxidation, and anti-osteoporosis. We have recorded results for the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) Reductase and urease enzymes at the µM level.
View Article and Find Full Text PDFRelationships between the Osteocalcin gene polymorphisms, serum osteocalcin levels, and hepatitis B virus-related hepatocellular carcinoma in a Chinese population.
PLoS One
December 2015
Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Background: Available evidence has demonstrated that osteocalcin may play a role in pathogenesis of cancer, and mutation of the osteocalcin gene may be involved in the cancer development. The aim of this study is to determine whether osteocalcin gene polymorphisms are associated with hepatitis B virus (HBV) related hepatocellular carcinoma (HCC) among Chinese population.
Methods: A total of 515 subjects were divided into four groups: 129 patients with chronic hepatitis B (CHB), 62 patients with HBV-related liver cirrhosis (LC), 154 patients with HBV-related HCC, and 170 healthy controls.