[CCDC97 influences the immune microenvironment and biological functions in HCC].

Objective To explore the clinical and immunological significance of CCDC97 in hepatocellular carcinoma (HCC). Methods Clinical data and RNA sequencing results from HCC patients were retrieved from TCGA and ICGC databases. Bioinformatics analysis and in vitro experiments were performed to investigate the role of CCDC97 in HCC.

Diverse strategies utilized by coronaviruses to evade antiviral responses and suppress pyroptosis.

Viral infections trigger inflammasome-mediated caspase-1 activation. Nevertheless, limited understanding exists regarding how viruses use the active caspase-1 to evade host immune response. Here, we use porcine epidemic diarrhea virus (PEDV) as a model of coronaviruses (CoVs) to illustrate the intricate regulation of CoVs to combat IFN-I signaling and pyroptosis.

LncRNA SERPINB9P1 Mitigates Cerebral Injury Induced by Oxygen‒Glucose Deprivation/Reoxygenation by Interacting with HSPA2.

Dysregulation of long non-coding RNAs (lncRNAs) is implicated in the pathophysiology of ischemic stroke (IS). However, the molecular mechanism of the lncRNA SERPINB9P1 in IS remains unclear. Our study aimed to explore the role and molecular mechanism of the lncRNA SERPINB9P1 in IS.

Comparative analysis of imaging and pathological features in diagnosis of endometrial carcinosarcoma based on multimodal MRI.

Purpose: This case report aims to present a rare case of endometrial carcinosarcoma, a highly malignant tumor with a poor prognosis. The primary objective is to describe this unique case's clinical presentation, multimodal magnetic resonance imaging (MRI) features, typical histopathological characteristics and surgical treatment.

Methods: A detailed analysis of the patient's medical history, preoperative imaging evaluation, and treatment approach was conducted.

CINet: A Constraint- and Interaction-Based Network for Remote Sensing Change Detection.

Remote sensing change detection (RSCD), which utilizes dual-temporal images to predict change locations, plays an essential role in long-term Earth observation missions. Although many deep learning based RSCD models perform well, challenges remain in effectively extracting change information between dual-temporal images and fully leveraging interactions between their feature maps. To address these challenges, a constraint- and interaction-based network (CINet) for RSCD is proposed.

Regulation of Age-Related Lipid Metabolism in Ovarian Cancer.

The mortality rate of ovarian cancer (OC) remains the highest among female gynecological malignancies. Advanced age is the highest risk factor for OC development and progression, yet little is known about the role of the aged tumor microenvironment (TME). We conducted RNA sequencing and lipidomic analysis of young and aged gonadal adipose tissue from rat xenografts before and after OC formation.

CircTEC Inhibits the Follicular Atresia in Buffalo () via Targeting miR-144-5p/FZD3 Signaling Axis.

The specific expression profile and function of circular RNA (circRNA) in follicular atresia remain largely unknown. Here, the circRNA expression profiles of granulosa cells derived from healthy follicles (HFs) and antral follicles (AFs) in buffalo were analyzed by RNA-seq, and the mechanism of a differentially expressed circRNA (DEcircRNA) circTEC regulating the granulosa cell function that affects follicular atresia was further explored. RNA-seq results showed that a total of 112 DEcircRNAs were identified.

Modification and Aging Mechanism of Crumb Rubber Modified Asphalt Based on Molecular Dynamics Simulation.

Asphalt modified with treated waste tires has good environmental protection and application value. However, the nano-modification mechanism of crumb rubber (CR) with asphalt is still unclear. This research investigates the mechanism, aging, and interfacial interaction with the aggregate of CR modification asphalt (CRMA).

Study on the Properties of Basalt Fiber-Calcined Gangue-Silty Clay Foam Concrete for Filling Undermined Goaf Areas of Highways.

The collapse of surface goaf beneath highways can result in instability and damage to roadbeds. However, filling the goaf areas with foam concrete can significantly enhance the stability of the roadbeds while considerably reducing the costs of filling materials. This study analyzes the effects on destructive characteristics, mechanical properties, stress-strain curve features, and relevant metrics, while also observing the microstructure of basalt fiber-calcined gangue-silty clay foam concrete (BF-CCG-SCFC).

Evaluating a Soil Amendment for Cadmium Mitigation and Enhanced Nutritional Quality in Faba Bean Genotypes: Implications for Food Safety.

Soil amendments combined with low cadmium (Cd)-accumulating crops are commonly used for remediating Cd contamination and ensuring food safety. However, the combined effects of soil amendments and the cultivation of faba beans ( L.)-known for their high nutritional quality and low Cd accumulation-in moderately Cd-contaminated soils remain underexplored.

Effects of Exogenous Boron on Salt Stress Responses of Three Mangrove Species.

Salt stress is common but detrimental to plant growth, even in mangroves that live in saline areas. Boron (B) is an essential micronutrient that performs an important role in many functions in plants; however, its protective role under salt stress is poorly understood, especially in long-lived woody plants. In this study, we conducted an indoor experiment under simulated tidal conditions with four treatments (10‱ salinity, 40‱ salinity, 40‱ salinity + 100 μM B, and 40‱ salinity + 500 μM B) and three mangrove species (, , and ) to investigate the effects of exogenous B on salt tolerance in plant growth, morphology, physiology, and leaf anatomy.

ATP Citrate Lyase Facilitates Citrate Cleavage in Lemon.

Citric acid is an important organic acid with wide applications and diverse biological functionality. As the predominant organic acid in lemons, citric acid plays a crucial role in determining the flavor of citrus, especially in lemons. ATP citrate lyase (ACL, EC4.

An Experimental and Quantum Chemical Calculation Study on the Performance of Different Types of Ester Collectors.

Ester collectors have rapidly developed into the main flotation collectors for copper sulfide minerals since they were developed. In this study, the collecting performance of four collectors, O-isopropyl-N-ethyl thionocarbamate ester (IPETC), 3-pentyl xanthate acrylate ester (PXA), O-isobutyl-N-allyl-thionocarbamate (IBALTC), and O-isobutyl-N-isobutoxycarbonyl-thionocarbamate (IBIBCTC), was investigated through microflotation tests, microcalorimetric measurements, and quantum chemical calculations. The results of the microflotation tests show that IBALTC and IPETC have stronger collecting abilities than IBIBCTC and PXA; the order of collecting ability is IBALTC > IPETC > IBIBCTC > PXA.

Genome-Wide Association Analysis of Boar Semen Traits Based on Computer-Assisted Semen Analysis and Flow Cytometry.

Semen quality and persistence are critical for evaluating the usability of individual boars in AI, a standard practice in pig breeding. We conducted GWASs on various semen traits of Duroc boars, including MOT, DEN, ABN, MMP, AIR, and ROS levels. These traits were assessed using FCM and CASA.

AM1241 inhibits chondrocyte inflammation and ECM degradation through the Nrf2/HO-1 and NF-κB pathways and alleviates osteoarthritis in mice.

Background: This study aimed to investigate the impact of AM1241 on lipopolysaccharide (LPS)-induced chondrocyte inflammation in mice and its potential mechanism for improving osteoarthritis (OA).

Methods: The OA mice model was established employing the refined Hulth method. The impact of different concentrations of AM1241 on mice chondrocyte activity was detected using CCK-8.

Mitochondrial genome structural variants and candidate cytoplasmic male sterility-related gene in sugarcane.

Background: Sugarcane is a crucial crop for both sugar and bioethanol production. The nobilization breeding and utilization of wild germplasm have significantly enhanced its productivity. However, the pollen sterility in Saccharum officinarum restricts its role to being a female parent in crosses with Saccharum spontaneum during nobilization breeding, resulting in a narrow genetic basis for modern sugarcane cultivars.

Metabolic and transcriptional analysis of tuber expansion in Curcuma kwangsiensis.

The tubers of Curcuma kwangsiensis are regarded as an important medicinal material in China. In C. kwangsiensis cultivation, tuber expansion is key to yield and quality, but the regulatory mechanisms are not well understood.

N6-methyladenosine-modification of USP15 regulates chemotherapy resistance by inhibiting LGALS3 ubiquitin-mediated degradation via AKT/mTOR signaling activation pathway in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is among the most malignant tumors and seriously threatens human health worldwide, and its incidence rate is increasing annually. USP15 is a member of the ubiquitination-specific protease (USP) family, which can regulate protein ubiquitination, thereby affecting their stability, and is dysregulated in many cancers, but its expression and regulatory mechanism in HCC are unclear. The aims of this study were to explore the role and mechanism of USP15 in regulating HCC cell stemness, proliferation, and lenvatinib resistance.

Novel Co-MOF-doped gelatin/agar intelligent film for beef freshness visual tracking based on the structural change of ZIF-67 under ammonia etching effect.

It is an important task to construct intelligent packaging for meat freshness monitoring with good color stability and indication function. Herein, cobalt-based metal-organic framework nanomaterials (Co-MOF, ZIF-67) with antimicrobial and ammonia-sensitive properties were successfully synthesized and added into gelatin/agar (GA) matrix to develop highly stable intelligent films (GA/ZIF67). The incorporation of ZIF-67 nanoparticles enhanced the hydrophobicity (water contact angle >90°) and UV-blocking properties (close to 0.

Process optimization, structural characterization, and biological activity of Siraitia grosvenorii polysaccharides by ultrasonic aqueous two-phase extraction.

In this research, ultrasound-assisted aqueous two-phase extraction (UA-ATPE) was utilized to isolate polysaccharides from Siraitia grosvenorii (SGPs). Based on the results of model optimization experiments, the extraction parameters were determined. The total extraction rate of SGPs was 25.

Confinement of carbon dots into carboxymethyl cellulose matrice to prepare solid-state fluorescent films and couple with Eu-MOF toward white light-emitting diodes.

As a novel fluorescent carbon nanomaterial, carbon dots are restricted by their poor fluorescence in the solid state, although they exhibit favorable photoluminescence in solution. N-doped carbon dots (N-CDs) and solid-state fluorescence films were prepared using green and renewable cellulose-derived materials, respectively. The hydrogen bonding network of carboxymethyl cellulose (CMC) inhibits the self-aggregation behavior of N-CDs, which leads to solid-state fluorescence.

Causal Association Between Cerebrospinal Fluid Metabolites and Parkinson's Disease: A Two-Sample Bidirectional Mendelian Randomization Study.

Objective: Observational studies suggest CSF metabolites may be linked to Parkinson's disease (PD) onset, but causality is uncertain. This study uses a two-sample bidirectional Mendelian randomization approach to investigate the causal relationship between CSF metabolites and PD.

Methods: Data on 338 CSF metabolites and PD-related traits were obtained from genome-wide association studies (GWAS).

Association between preoperative serum albumin levels and length of stay in elderly patients with hip fractures: A nonlinear relationship.

Previous studies have provided relatively limited evidence in examining the impact of preoperative serum albumin levels on the length of hospital stay (LOS) in patients with hip fractures. This study aimed to elucidate the association between preoperative serum albumin levels and LOS in elderly patients with hip fractures. This retrospective cohort study included 1444 elderly patients undergoing surgical treatment for hip fractures at the Second People's Hospital of Shenzhen from January 2012 to December 2021.