Exploring the dual roles of sec-dependent effectors from Candidatus Liberibacter asiaticus in immunity of citrus plants.

The three SDEs of CLas were expressed in citrus leaves by AuNPs-PEI mediated transient expression system, and promoted the proliferation of CLas and inhibited citrus immunity. Huanglongbing (HLB) is the most severe bacterial disease of citrus caused by Candidatus Liberibacter asiaticus (CLas). CLas suppress host immune responses and promote infection by sec-dependent effectors (SDEs), thus insight into HLB pathogenesis is urgently needed to develop effective management strategies.

sVEGFR3 alleviates myocardial ischemia/reperfusion injury through regulating mitochondrial homeostasis and immune cell infiltration.

Recent studies have suggested that sVEGFR3 is involved in cardiac diseases by regulating lymphangiogenesis; however, results are inconsistent. The aim of this study was to investigate the function and mechanism of sVEGFR3 in myocardial ischemia/reperfusion injury (MI/RI). sVEGFR3 effects were evaluated in vivo in mice subjected to MI/RI, and in vitro using HL-1 cells exposed to oxygen-glucose deprivation/reperfusion.

Glutamate molecular structure and protein affect the inhibition of breast cancer cell metastasis: Cell-derived exosomes inhibitory effects through the MAPK signaling pathway.

The aim of this study was to investigate the inhibitory effect of glutamate molecular structure and protein on breast cancer cell metastasis and the potential inhibitory mechanism of cell-derived exosomes via MAPK signaling pathway. Breast cancer cell lines with high metastatic potential were selected by in vitro cell culture technique. The effects of specific inhibitors of glutamic acid on the proliferation and metastasis of breast cancer cells were studied.

The strigolactones-mediated DNA demethylation activates the phosphoinositide pathway in response to salt stress.

Salt stress severely affects the growth and development of tomato. Strigolactones (SLs) and DNA methylation have been shown to be involved in the growth and development and response to salt stress in tomato. However, the regulation of SLs on DNA methylation in tomato under salt stress remains unclear.

In-situ engineering of centralized mesopores and edge nitrogen for porous carbons toward zinc ion hybrid capacitors.

Porous carbons with large surface area (>3000 m/g) and heteroatom dopants have shown great promise as electrode materials for zinc ion hybrid capacitors. Centralized mesopores are effective to accelerate kinetics, and edge nitrogen can efficiently enhance pseudocapacitive capability. It is a great challenge to engineer centralized mesopores and edge nitrogen in large-surface-area porous carbons.

STAT4 gene polymorphism may be associated with microscopic polyangiitis susceptibility in a Chinese Guangxi population: A case-control analysis based on propensity score matching.

Background: Microscopic polyangiitis (MPA) is a severe multisystem autoimmune disease featured by small-vessel vasculitis with few or no immune complex, also has a significant genetic predisposition. Growing evidence has confirmed that STAT4 gene is tightly associated with multiple autoimmune diseases, but its contribution to MPA onset is still elusive.

Objective: The aim was to investigated the association between STAT4 gene polymorphisms (rs7572482, rs7574865 and rs12991409) and MPA susceptibility in a Guangxi population of China.

Multi-metal mixture exposure and cognitive function in urban older adults: The mediation effects of thyroid hormones.

The existing studies on the association between multi-metal mixture exposure and cognitive function in the older adults are limited and controversial, with no studies considering the mediating effect of thyroid hormones on the connection between them. This study of 441 urban older adults assessed 21 urinary metal levels and cognitive function using the Mini-Mental State Examination (MMSE). Urinary metal levels were measured via inductively coupled plasma mass spectrometry (ICP-MS), and thyroid hormones levels were obtained from medical records.

A study on how to improve students' continuance intention in landscape architecture conservation course within a virtual learning environment based on SVVR.

With the rapid pace of global urbanization, preserving natural landscapes has become increasingly critical. However, urbanization presents significant environmental risks worsened by decreased ecological consciousness. This has led to a pressing demand for education in landscape conservation.

Sialic Acid-Modified NIR-II Fluorophore with Enhanced Brightness and Photoconversion Capability for Targeted Lymphoma Phototheranostics.

Lymphoma is a malignant cancer characterized by a rapidly increasing incidence, complex etiology, and lack of obvious early symptoms. Efficient theranostics of lymphoma is of great significance in improving patient outcomes, empowering informed decision-making, and driving medical innovation. Herein, we developed a multifunctional nanoplatform for precise optical imaging and therapy of lymphoma based on a new photosensitizer (1-oxo-1-benzoo[de]anthracene-2,3-dicarbonitrile-triphenylamine (OBADC-TPA)).

Inhibition of Endothelial-Mesenchymal Transition Mediated by Activin Receptor Type IIA Attenuates Valvular Injury Induced by Group A Streptococcus in Lewis Rats.

Background: Rheumatic heart disease (RHD), which is caused mainly by Group A Streptococcus, leads to fibrotic damage to heart valves. Recently, endothelial‒mesenchymal transition (EndMT), in which activin plays an important role, has been shown to be an important factor in RHD valvular injury. However, the mechanism of activin activity and EndMT in RHD valvular injury is not clear.

Identification of chemical constituents and absorbed components in rat serum of (L.) Jacq. by UPLC-Q-exactive-MS.

(L.) Jacq. has anti-inflammatory, analgesic, haemostatic and antioxidant effects, but its pharmacological components are still unclear.

Asperhydrindane A, a new hydrindane derivate isolated from a mangrove-derived fungi GXIMD 03158.

A new hydrindane derivative, asperhydrindane A (), along with two known sterol analogues [isocyathisterol () and ganodermasides D ()] were isolated from the mangrove-derived fungus GXIMD 03158 attaching to the mangrove L. The structure of was elucidated based on extensive spectral analysis, HRESIMS, and calculated ECD methods. All compounds were evaluated for antibacterial activity.

Fabrication and Performance Enhancement of Wood Liquefaction-Based Carbon Fibers Modified with Alumina Nanoparticles.

In this paper, alumina-modified wood liquefaction (AL-WP) was prepared by blending nano-alumina (AlO) into wood liquefaction phenolic resin (WP) using a co-blending method. Alumina-modified wood liquefaction protofilament fiber (AL-WPF) was obtained by melt-spinning, curing, and thermo-curing processes, which were followed by carbonization to obtain alumina-modified wood liquefaction carbon fiber (AL-WCF). This paper focuses on the enhancement effect of nano-alumina doping on the mechanical properties and heat resistance of wood liquefaction carbon fiber (WCF), explores the evolution of graphite microcrystalline structure during the high-temperature carbonization process, and optimizes the curing conditions of AL-WPF.

A Novel Particle Filter Based on One-Step Smoothing for Nonlinear Systems with Random One-Step Delay and Missing Measurements.

In this paper, a novel particle filter based on one-step smoothing is proposed for nonlinear systems with random one-step delay and missing measurements. Such problems are commonly encountered in networked control systems, where random one-step delay and missing measurements significantly increase the difficulty of dynamic state estimation. The particle filter is a nonlinear filtering method based on sequential Monte Carlo sampling.

Enhanced Electrochemical Performance of Dual-Ion Batteries with T-NbO/Nitrogen-Doped Three-Dimensional Porous Carbon Composites.

Niobium pentoxide (T-NbO) is a promising anode material for dual-ion batteries due to its high lithium capacity and fast ion storage and release mechanism. However, T-NbO suffers from the disadvantages of poor electrical conductivity and fast cycling capacity decay. Herein, a nitrogen-doped three-dimensional porous carbon (RMF) was prepared for loading niobium pentoxide to construct a composite system with excellent electrochemical performance.

Investigations on Beekeeping and Breeding of in China.

The worldwide value of the honey bee as an agricultural animal is increasingly being recognized. Not only does the honey bee directly produce useful agricultural products, but also large portions of crops are dependent on the pollination activities of honey bees. (), the native honey bee of China, is widely distributed in the country.

Crystal Structure and Magnetic Properties of the Novel Compound ErMnGe.

The RE-M-Ge systems (RE: rare earths, M: transition group elements) contain a large number of compounds with special magnetic properties. A novel compound ErMnGe was found during the investigation on the phase diagram of the Er-Mn-Ge ternary system, and its crystal structure and magnetic properties were investigated. Powder X-ray diffraction results show that ErMnGe crystallizes in an orthorhombic YNiSi-type structure with the space group Pnma (No.

New Brusatol Derivatives as Anti-Settlement Agents Against Barnacles, Targeting HSP90: Design, Synthesis, Biological Evaluation, and Molecular Docking Investigations.

The increasing challenge of marine biofouling, mainly due to barnacle settlement, necessitates the development of effective antifoulants with minimal environmental toxicity. In this study, fifteen derivatives of brusatol were synthesized and characterized using C-NMR, H-NMR, and mass spectrometry. All the semi-synthesized compounds obtained using the Multi-Target-Directed Ligand (MTDL) strategy, when evaluated as anti-settlement agents against barnacles, showed promising activity.

Construction of a High-Density Genetic Linkage Map and QTL Mapping for Stem Rot Resistance in Passion Fruit ( Sims).

Background: The passion fruit ( Sims) is a diploid plant (2n = 2x = 18) and is a perennial scrambling vine in Southern China. However, the occurrence and spread of stem rot in passion fruit severely impact its yield and quality.

Methods: In this study, we re-sequenced a BCF population consisting of 158 individuals using whole-genome resequencing.

Recombinant Abelson Tyrosine Protein Kinase (rAbl) Regulates Various Functions of Buffalo Peripheral Blood Mononuclear Cells.

can modulate host immune mechanisms through excretory-secretory products (ESP). As one of the components of ESP, it is unknown whether Abelson tyrosine protein kinase (Abl) is involved in parasite-host immune interaction. To investigate the immunoregulatory function of Abl in , we cloned and expressed the gigantica Abl protein and assessed its effect on specific immune functions of buffalo peripheral blood mononuclear cells (PBMCs).

Evaluating Ecosystem Characteristics and Ecological Carrying Capacity for Marine Fauna Stock Enhancement Within a Marine Ranching System.

China has recently launched extensive marine ranching projects, highlighting the need for scientific evaluation of ecosystem structure and function to guide their development. This study established two energy flow models and an evaluation index system to assess the structure, function, carrying capacity, and ecological status of both a marine ranching ecosystem and a nearby control site in the Beibu Gulf. The results show that the ranching ecosystem outperformed the control ecosystem in terms of food chain length, system size, and ecological carrying capacity of economically important species.

Comprehensive Overview of Ketone Bodies in Cancer Metabolism: Mechanisms and Application.

Reprogramming energy metabolism is pivotal to tumor development. Ketone bodies (KBs), which are generated during lipid metabolism, are fundamental bioactive molecules that can be modulated to satisfy the escalating metabolic needs of cancer cells. At present, a burgeoning body of research is concentrating on the metabolism of KBs within tumors, investigating their roles as signaling mediators, drivers of post-translational modifications, and regulators of inflammation and oxidative stress.

Population Genomics Reveals Elevated Inbreeding and Accumulation of Deleterious Mutations in White Raccoon Dogs.

The formation of animal breeds usually begins with a small subsample from their ancestral population. Deleterious mutations accumulate in the population under genetic drift, inbreeding, and artificial selection during the development and maintenance of traits desired by humans. White raccoon dogs are among the most popular breeds of farmed raccoon dogs, but white raccoon dogs are more susceptible to disease and have a lower reproductive ability.

Untargeted Metabolomics Reveals Key Differences Between Yak, Buffalo, and Cow Colostrum Based on UHPLC-ESI-MS/MS.

Background: Colostrum, abundant in immunoglobulins and growth factors, plays a vital role in supporting immunity. Both yak and buffalo milk are characterized by their high protein and fat content. However, the metabolomic profiles of yak colostrum (YC), buffalo colostrum (BC), and bovine colostrum (CC) remain largely unexplored.

γ-Aminobutyric Acid (GABA) Metabolic Bypass Plays a Crucial Role in Stress Tolerance and Biofilm Formation in ATCC 29544.

is a foodborne pathogen characterized by its robust stress tolerance and ability to form biofilms, which facilitates its survival in powdered infant formula (PIF) processing environments for prolonged periods. Gamma-aminobutyric acid (GABA) is a kind of non-protein amino acid that acts as an osmoprotectant. This study aimed to elucidate the effects of the gene on the survival of , GABA accumulation, and biofilm formation under desiccation, osmotic stress, and acid exposure.