25,156 results match your criteria: "Nankai University.[Affiliation]"

[Efficacy of modified nasal transposition of the split lateral rectus muscle for large-angle exotropia from oculomotor nerve palsy].

Zhonghua Yan Ke Za Zhi

January 2025

Tianjin Eye Hospital, Nankai University Affiliated Eye Hospital, Clinical College of Ophthalmology of Tianjin Medical University, Tianjin Eye Institute, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin300020, China.

To explore the efficacy of the modified lateral rectus muscle splitting and nasal transposition surgery in treating large-angle exotropia caused by oculomotor nerve palsy and its impact on ocular motility. Retrospective case series study. Data was collected from patients diagnosed with large-angle exotropia due to oculomotor nerve palsy and treated by modified lateral rectus muscle splitting and nasal transposition surgery at the Tianjin Eye Hospital from January 2020 to October 2023.

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[Further raising prevention and treatment for amblyopia in China].

Zhonghua Yan Ke Za Zhi

January 2025

Tianjin Eye Hospital, Nankai University Affiliated Eye Hospital, Clinical College of Ophthalmology of Tianjin Medical University, Tianjin Eye Institute, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin300020, China.

Amblyopia is a common eye disease that seriously affects children's eye health. The Chinese Association for Pediatric Ophthalmology and Strabismus has carried out a lot of work for the prevention and treatment of amblyopia, but there are still many problems that need to be paid attention to and solved in the amblyopia screening and clinical diagnosis and treatment. In this article, we discuss three aspects of the amblyopia prevention and treatment, including the timing of prevention and treatment according to visual developmental patterns, the standardized treatment of amblyopia, overdiagnosis and commercialization, and the establishment of an efficient amblyopia screening system, for providing guidance for the standardization of clinical practice and improving the level of amblyopia prevention and treatment in China.

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[Progress on the application of polypeptide hydrogels in drug sustained/controlled release].

Zhonghua Kou Qiang Yi Xue Za Zhi

January 2025

Deapartment of Central Laboratory, Tianjin Stomatological Hospital, School of Medicine, Nankai University & Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin300041, China.

In recent years, peptide hydrogels have garnered significant attention in the biomedical field due to their excellent biocompatibility, biodegradability, and low cytotoxicity. They can mimic the microenvironment of the extracellular matrix, effectively encapsulate drugs, and achieve sustained or controlled drug release, thereby facilitate tissue regeneration. This article introduces the research progress in the application of peptide hydrogels for drug sustained/controlled release.

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PDIA4 targets IRE1α/sXBP1 to alleviate NLRP3 inflammasome activation and renal tubular injury in diabetic kidney disease.

Biochim Biophys Acta Mol Basis Dis

December 2024

Department of Pathology, School of Medicine, Nankai University, Tianjin, China. Electronic address:

The role of ER stress in the pathogenesis of diabetic kidney diseases (DKD) remains unclear. We employed bioinformatics to identify the UPR pathway activation, inflammation, and programmed cell death patterns in diabetic tubules. Levels of IRE1α/sXBP1 signaling, NLRP3 inflammasome activity and pyroptosis in tubular cells under high glucose conditions were measured.

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Developmental dynamics mimicking inversely engineered pericellular matrix for articular cartilage regeneration.

Biomaterials

December 2024

School of Medicine, Nankai University, Tianjin, 300071, PR China; Institute of Orthopedics, The First Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing, 100853, PR China; National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, Beijing, 100853, PR China. Electronic address:

The mechanical mismatch of scaffold matrix-mesenchymal stem cells (MSCs) has been a longstanding issue in the clinical application of MSC-based therapy for articular cartilage (AC) regeneration. Existing tissue-engineered scaffolds underestimate the importance of the natural chondrocyte pericellular matrix (PCM). Here, we reveal the temporal and spatial characteristics of collagen distribution around the chondrocytes.

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Corrigendum to "Drug content on anticancer efficacy of self-assembling ketal-linked dextran-paclitaxel conjugates" [Journal of Controlled Release 359 (2023) 175-187].

J Control Release

December 2024

Key Laboratory of Functional Polymer Materials of Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, China. Electronic address:

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Copper(II)-Catalyzed Enantioselective Addition of Aryl Amines to Isatin-Derived -Boc-Ketimines for the Synthesis of Acyclic ,'-Ketals.

J Org Chem

January 2025

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, China.

Here, we demonstrated a copper(II)-catalyzed enantioselective addition of aryl amines to isatin-derived -Boc-ketimines using chiral O-N-N tridentate ligands derived from BINOL and proline. Generally, the chiral acyclic ,'-ketals were obtained in high yields (up to 98%) and excellent ee values (up to 98%). Various aryl amines could be tolerated and a gram-scale reaction was also possible.

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Pluripotent stem cells possess a unique nuclear architecture characterized by a larger nucleus and more open chromatin, which underpins their ability to self-renew and differentiate. Here, we show that the nucleolus-specific RNA helicase DDX18 is essential for maintaining the pluripotency of human embryonic stem cells. Using techniques such as Hi-C, DNA/RNA-FISH, and biomolecular condensate analysis, we demonstrate that DDX18 regulates nucleolus phase separation and nuclear organization by interacting with NPM1 in the granular nucleolar component, driven by specific nucleolar RNAs.

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The strain-release-driven reactions of bicyclo[1.1.0]butanes (BCBs) have received significant attention from chemists.

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Three-component diels-alder reaction through palladium carbene migratory insertion enabled dearomative C(sp)-H bond activation.

Nat Commun

December 2024

Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education of China, Key Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan Province, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, Hunan, 410081, China.

Owning to the versatile nature in participation of Diels-Alder (D-A) reactions, the development of efficient approaches to generate active ortho-quinodimethanes (o-QDMs) has gained much attention. However, a catalytic method involving coupling of two readily accessible components to construct o-QDMs is lacking. Herein, we describe a palladium carbene migratory insertion enabled dearomative C(sp)-H activation to form active o-QDM species through the cross-coupling of N-tosylhydrazones with aryl halides.

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By targeting the essential viral RNA-dependent RNA polymerase (RdRP), nucleoside analogs (NAs) have exhibited great potential in antiviral therapy for RNA virus-related diseases. However, most ribose-modified NAs do not present broad-spectrum features, likely due to differences in ribose-RdRP interactions across virus families. Here, we show that HNC-1664, an adenosine analog with modifications both in ribose and base, has broad-spectrum antiviral activity against positive-strand coronaviruses and negative-strand arenaviruses.

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A Straightforward Synthetic Route to Monocyclic 1,3,2,4-Diazadiborinines.

Inorg Chem

January 2025

School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, P. R. China.

A novel straightforward synthetic route to monocyclic 1,3,2,4-diazadiborinines has been developed by the sequential reaction of the NHC-coordinated iminoborane with bases and haloboranes (or borate). The first examples of monocyclic 1,3,2,4-diazadiborinines featuring different functional groups on the two B atoms have been synthesized and structurally characterized. Further derivatization of 4-bromophenyl-substituted 1,3,2,4-diazadiborinine has also been achieved, giving the biphenyl-substituted 1,3,2,4-diazadiborinine.

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Highly Sensitive Low-Frequency Acoustic Sensor Based on Functionalized Graphene Oxide.

Small

December 2024

State Key Laboratory of Precision Measurement Technology and Instruments, School of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin, 300072, China.

Developing miniaturized low-frequency acoustic sensors with high sensitivity is crucial for diverse applications, including geological monitoring and aerospace exploration. However, the performance of low-frequency acoustic sensor is constrained by the limited mechanical robustness of traditional sensing films at nanoscale thickness. Here, a functionalized graphene oxide (GO)-based Fabry-Perot (FP) low-frequency sensor is proposed, with characteristics of compact size, resistance to electromagnetic interference high-sensitivity low minimum detectable pressure (MDP), and a high signal-to-noise ratio (SNR).

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Age, frequency, and strategy optimization for organized colorectal cancer screening: a decision analysis conducted in China for the years 2023-2038.

BMC Cancer

December 2024

Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, No. 5 Dongdansantiao Street, Dongcheng District, Beijing, 100005, China.

Background: The colorectal cancer mortality rate in China has exceeded that in many developing countries and is expected to further increase owing to multiple factors, including the aging population. However, the optimal policy for colorectal cancer screening is unknown.

Methods: We synthesized the most up-to-date data using a 12-state Markov model populated with a cohort of Chinese men and women born during 1949-1988, and evaluated 16 conventional and 40 risk-tailored schemes for colorectal cancer screening, considering possible combinations of age (starting at 40 + years and ending at 75 years), frequency, and strategy (standard colonoscopy, fecal immunochemical testing with colonoscopy if positive, or risk-tailored).

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Metabolomic Profiling Reveals Biomarkers in Coronary Heart Disease Comorbidity.

J Diabetes Res

December 2024

Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, Shandong, China.

Coronary heart disease (CHD), hypertension (HTN), depression (Dep), and Type 2 diabetes mellitus (T2DM) are often comorbid, resulting in an exacerbated patient condition and worsened prognosis. A lack of systematic metabolomic studies on comorbidities of CHD remains. Therefore, comprehensive metabolomic-based evaluation of comorbidities of CHD is necessary.

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The effect of right versus left long-term single-sided deafness on sound source localization.

J Otol

July 2024

Department of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, 100853, China.

Purpose: To analyze the effect of right versus left long-term single-sided deafness (SSD) on sound source localization (SSL), discuss the necessity of intervention and treatment for SSD patients, and analyze the therapeutic effect of long-term unilateral cochlear implantation (UCI) from the perspective of SSL.

Methods: This study included 25 patients with SSD, 11 patients with UCI, and 30 participants with normal hearing (NH). Their SSL ability was tested by obtaining their average root mean square (RMS) error values of SSL test.

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Primary Cilia Regulate the Homeostasis and Regeneration of the Stem Cell Niche in the Tooth.

J Cell Physiol

January 2025

Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, Tianjin Medical University School of Stomatology, Tianjin Medical University, Tianjin, China.

Primary cilia, functioning as crucial hubs for signal sensing and transduction, are integral to the development and maintenance of homeostasis across various organs. However, their roles in tooth homeostasis and repair remain inadequately understood. In this study, we reveal an indispensable role for primary cilia in regulating the homeostasis and regeneration of teeth, primarily through the regulation of cell proliferation.

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Analyzing the effect of surgical and corneal parameters on the postoperative refractive outcomes of SMILE in myopic eyes based on machine learning.

Am J Ophthalmol

December 2024

Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China; School of Medicine, Nankai University, Tianjin, China; Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute, Nankai University Affiliated Ophthalmology Hospital, Tianjin, China; Nankai Eye Institute, Nankai University, Tianjin, China. Electronic address:

Purpose: To analyze the effect of individual parameters on the postoperative refractive outcomes of small incision lenticule extraction in myopic eyes using machine learning methods.

Design: Retrospective Clinical Cohort Study METHODS: We included 477 patients (922 eyes) of small incision lenticule extraction at Tianjin Ophthalmology Hospital and divided the patients into two groups to analyzed the factors affecting postoperative refractive outcomes based on the label of postoperative spherical equivalent (SE) ≤ -0.50D.

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The main objective of this study was to evaluate the potential of near infrared (NIR) spectroscopy and machine learning in detecting microplastics (MPs) in chicken feed. The application of machine learning techniques in building optimal classification models for MPs-contaminated chicken feeds was explored. 80 chicken feed samples with non-contaminated and 240 MPs-contaminated chicken feed samples including polypropylene (PP), polyvinyl chloride (PVC), and polyethylene terephthalate (PET) were prepared, and the NIR diffuse reflectance spectra of all the samples were collected.

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PrPc is expressed in various tumors and is associated with cancer progression, but previous studies have shown conflicting results regarding its relationship with patient prognosis-potentially due to differences in the antibodies used. This study aimed to clarify the relationship between PrPc expression and primary esophageal squamous cell carcinoma (ESCC) and primary hepatocellular carcinoma (HCC) using a novel anti-PrPc antibody, 4AA-m, noted for its high specificity and sensitivity. We used flow cytometry to detect PrPc expression in ESCC and HCC cell lines.

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Dual-domain superoxide dismutase: In silico prediction directed combinatorial mutation for enhanced robustness and catalytic efficiency.

Int J Biol Macromol

December 2024

Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, TEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin 300457, PR China; Tianjin Key Laboratory of Microbial Functional Genomics, Tianjin 300457, PR China. Electronic address:

The robustness and catalytic activity of superoxide dismutase (SOD) are still the main factors limiting their application in industrial fields. This study aims to further improve the properties of a natural thermophilic iron/manganese dual-domain SOD (Fe/Mn-SODA fused with N-terminal polypeptide) from Geobacillus thermodenitrificans NG80-2 (GtSOD) by modifying its each domain using in-depth in silico prediction analysis as well as protein engineering. First, computational analysis of the N-terminal domain and GtSODA domain was respectively performed by using homologous sequence alignment and virtual mutagenesis.

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Identification of assembly mode of non-canonical BAF (ncBAF) chromatin remodeling complex core module.

Biochem Biophys Res Commun

January 2025

State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Science, and College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin, 300071, China. Electronic address:

Mammalian SWI/SNF (mSWI/SNF) ATP-dependent chromatin remodeling complexes play critical roles in regulating gene expression and DNA accessibility, and more than 20 % of cancers have mutations in genes encoding chromatin remodeling complexes. The mSWI/SNF family comprises three distinct classes: canonical BAF (cBAF), PBAF, and non-canonical BAF (ncBAF). While the structures of cBAF and PBAF have been resolved by using cryo-electron microscopy (cryo-EM), the modular organization and assembly mechanism of ncBAF remain poorly understood.

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M13 bacteriophage based fluorescence immunoassay against food allergens of Ara h 3 and Mac i 1.

Food Chem

December 2024

Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China. Electronic address:

Food allergy is increasingly prevalent and poses notable health risks, which underscores the urgent need to develop reliable and sensitive detection methods for effective identification of food allergens. This study aims to address the limitations of existing methods by developing an immunoassay utilizing bacteriophage/carbon dots (CDs)@silica core-shell nanospheres. Two CDs with different emission wavelengths (513 nm for Green CDs, 645 nm for Red CDs) were synthesized for signal development and amplification.

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HMOX1-LDHB interaction promotes ferroptosis by inducing mitochondrial dysfunction in foamy macrophages during advanced atherosclerosis.

Dev Cell

December 2024

Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China; Heilongjiang Provincial Key Laboratory of Panvascular Disease, Harbin 150086, China; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin 150081, China; State Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin 150080, China. Electronic address:

Advanced atherosclerosis is the pathological basis for acute cardiovascular events, with significant residual risk of recurrent clinical events despite contemporary treatment. The death of foamy macrophages is a main contributor to plaque progression, but the underlying mechanisms remain unclear. Bulk and single-cell RNA sequencing demonstrated that massive iron accumulation in advanced atherosclerosis promoted foamy macrophage ferroptosis, particularly in low expression of triggering receptor expressed on myeloid cells 2 (TREM2) foamy macrophages.

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Efficient Orthogonal Spin Labeling of Proteins via Aldehyde Cyclization for Pulsed Dipolar EPR Distance Measurements.

J Am Chem Soc

January 2025

State Key Laboratory of Elemento-organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.

Pulsed dipolar electron paramagnetic resonance (PD-EPR) measurement is a powerful technique for characterizing the interactions and conformational changes of biomolecules. The extraction of these distance restraints from PD-EPR experiments relies on manipulation of spin-spin pairs. The orthogonal spin labeling approach offers unique advantages by providing multiple distances between different spin-spin pairs.

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