25,153 results match your criteria: "Nankai University.[Affiliation]"

Rbfox3 Promotes Transformation of MDSC-Like Tumor Cells to Shape Immunosuppressive Microenvironment.

Adv Sci (Weinh)

January 2025

State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, 300450, China.

Myeloid-derived suppressor cells (MDSCs) within the tumor microenvironment (TME) contribute to the malignant progression of tumors by exerting immunosuppressive effects. Bacterial lipopolysaccharides (LPS) have been widely demonstrated in various types of solid tumors. LPS can promote the malignant progression of tumors, which mechanism has not yet been fully elucidated.

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Enhanced Cooperative Generalized Compressive Strain and Electronic Structure Engineering in W-NiN for Efficient Hydrazine Oxidation Facilitating H Production.

Adv Mater

January 2025

Frontiers Science Center for New Organic Matter, Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), State Key Laboratory of Advanced Chemical Power Sources, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), College of Chemistry, Nankai University, Tianjin, 300071, China.

As promising bifunctional electrocatalysts, transition metal nitrides are expected to achieve an efficient hydrazine oxidation reaction (HzOR) by fine-tuning electronic structure via strain engineering, thereby facilitating hydrogen production. However, understanding the correlation between strain-induced atomic microenvironments and reactivity remains challenging. Herein, a generalized compressive strained W-NiN catalyst is developed to create a surface with enriched electronic states that optimize intermediate binding and activate both water and NH.

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We estimated the monetary value of informal care from the perspectives of informal caregivers and care recipients in China using the contingent valuation method. Data were obtained from a specially designed survey of 1458 informal caregivers and 972 care recipients. The mean for caregivers' willingness to pay (WTP) for reducing informal care by 1 h per week was CNY32.

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Background: Hepatocellular carcinoma (HCC) has been a pervasive malignancy throughout the world with elevated mortality. Efficient therapeutic targets are beneficial to treat and predict the disease. Currently, the exact molecular mechanisms leading to the progression of HCC are still unclear.

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Background: Clozapine exhibits significant therapeutic efficacy in schizophrenia, especially treatment-resistant schizophrenia. However, clozapine can cause agranulocytosis, a fatal adverse effect, and the aim of this study is to explore this mechanism based on network pharmacology and molecular docking.

Method: Six and two databases were used to identify targets associated with clozapine and agranulocytosis, respectively.

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Ferroelectric Optical Memristors Enabled by Non-Volatile Electro-Optic Effect.

Adv Mater

January 2025

Institute of Modern Optics & Tianjin Key Laboratory of Micro-Scale Optical Information Science and Technology, Nankai University, Tianjin, 300350, P. R. China.

Memristors enable non-volatile memory and neuromorphic computing. Optical memristors are the fundamental element for programmable photonic integrated circuits due to their high-bandwidth computing, low crosstalk, and minimal power consumption. Here, an optical memristor enabled by a non-volatile electro-optic (EO) effect, where refractive index modulation under zero field is realized by deliberate control of domain alignment in the ferroelectric material Pb(MgNb)O-PbTiO(PMN-PT) is proposed.

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Suppression of Sepsis Cytokine Storm by Escherichia Coli Cell Wall-Derived Carbon Dots.

Adv Mater

January 2025

State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, 300350, China.

Article Synopsis
  • Sepsis is a severe condition caused by an uncontrolled immune reaction to infections, often involving harmful bacteria like E. coli, and currently lacks effective treatments.
  • Researchers developed E. coli wall-derived carbon dots (E-CDs) that can reduce inflammation and improve survival rates in septic mice by binding to immune receptors and preventing excessive immune responses.
  • E-CDs also show promise in other models, reducing inflammation and oxidative stress, suggesting they could be a new therapeutic approach for treating sepsis by utilizing pathogen-derived materials.
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Dissolution, solvation and diffusion in low-temperature zinc electrolyte design.

Nat Rev Chem

January 2025

Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), College of Chemistry, Nankai University, Tianjin, China.

Aqueous zinc-based batteries have garnered the attention of the electrochemical energy storage community, but they suffer from electrolytes freezing and sluggish kinetics in cold environments. In this Review, we discuss the key parameters necessary for designing anti-freezing aqueous zinc electrolytes. We start with the fundamentals related to different zinc salts and their dissolution and solvation behaviours, by highlighting the effects of anions and additives on salt solubility, ion diffusion and freezing points.

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Multifaceted roles of UFMylation in health and disease.

Acta Pharmacol Sin

January 2025

Center for Cell Structure and Function, Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, 250014, China.

Ubiquitin fold modifier 1 (UFM1) is a newly identified post-translational modifier that is involved in the UFMylation process. Similar to ubiquitination, UFMylation enables the conjugation of UFM1 to specific target proteins, thus altering their stability, activity, or localization. UFM1 chains have the potential to undergo cleavage from their associated proteins via UFM1-specific proteases, thus highlighting a reversible feature of UFMylation.

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Observing non-Hermiticity induced chirality breaking in a synthetic Hall ladder.

Light Sci Appl

January 2025

State Key Laboratory of Advanced Optical Communication Systems and Networks, School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, 200240, China.

Non-Hermitian topological photonics plays a key role in bridging topological matter with gain and loss engineering in optics. Here we report the experimental observation of the break of chiral currents in a Hall ladder from the non-Hermiticity by constructing synthetic frequency dimension in two rings, where currents on both legs of the ladder co-propagate in the same direction. The origin of such phenomena is resulted from the interplay between the effective magnetic flux and the on-site gain and loss.

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Structural insights into the activation mechanism of the human zinc-activated channel.

Nat Commun

January 2025

State Key Laboratory of Medicinal Chemical Biology and Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, Tianjin, 300350, China.

The zinc-activated channel (ZAC) is an atypical mammalian cys-loop receptor (CLR) that is activated by zinc ions and protons, allowing cations to pass through. The molecular mechanism that ligands use to activate ZAC remains elusive. Here, we present three cryo-electron microscopy reconstructions of human ZAC (hZAC) under different conditions.

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Mechanical Twisting-Induced Enhancement of Second-Order Optical Nonlinearity in a Flexible Molecular Crystal.

J Am Chem Soc

January 2025

School of Materials Science and Engineering, Tianjin Key Laboratory of Metal and Molecular Materials Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tongyan Road 38, Tianjin 300350, P. R. China.

Flexible molecular crystals are essential for advancing smart materials, providing unique functionality and adaptability for applications in next-generation electronics, pharmaceuticals, and energy storage. However, the optical applications of flexible molecular crystals have been largely restricted to linear optics, with nonlinear optical (NLO) properties rarely explored. Herein, we report on the application of mechanical twisting of flexible molecular crystals for second-order nonlinear optics.

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Targeted Degradation of HCV Polymerase by GalNAc-Conjugated ApTACs for Pan-Genotypic Antiviral Therapy with High Resistance Barriers.

J Med Chem

January 2025

Department of Ophthalmology, Tianjin Medical University General Hospital, International Joint Laboratory of Ocular Diseases (Ministry of Education), Tianjin Key Laboratory of Ocular Trauma, Tianjin Institute of Eye Health and Eye Diseases, China-U.K. "Belt and Road" Ophthalmology Joint Laboratory, Laboratory of Molecular Ophthalmology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, Tianjin 300070, China.

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease. Although interferon-free direct-acting antivirals have led to significant advancements in the treatment of HCV infection, the high genetic variability of the virus and the emergence of acquired drug resistance pose potential threats to their effectiveness. In this study, we develop a broad-spectrum aptamer-based proteolysis targeting chimera, designated dNS5B, which effectively degrades both pan-genotypic NS5B polymerase and drug-resistant mutants through ubiquitin proteasome system.

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Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with a notably poor response to therapy due to its immunosuppressive tumor microenvironment (TME) and intrinsic drug resistance. The oncolytic virus (OV) represents a promising therapeutic strategy capable of transforming the "cold" immunological profile of PDAC tumors to a "hot" one by reshaping the TME. 4-1BB (CD137), a crucial member of the tumor necrosis factor receptor superfamily, plays a significant role in T-cell activation and function.

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Network Dismantling on Signed Network by Evolutionary Deep Reinforcement Learning.

Sensors (Basel)

December 2024

School of Statistics and Data Science, Nankai University, Tianjin 300074, China.

Network dismantling is an important question that has attracted much attention from many different research areas, including the disruption of criminal organizations, the maintenance of stability in sensor networks, and so on. However, almost all current algorithms focus on unsigned networks, and few studies explore the problem of signed network dismantling due to its complexity and lack of data. Importantly, there is a lack of an effective quality function to assess the performance of signed network dismantling, which seriously restricts its deeper applications.

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Protective Effects of Cereal-Based Fermented Beverages Against 5-Fluorouracil-Induced Intestinal Damage in Mice.

Nutrients

December 2024

Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China.

Background: 5-Fluorouracil (5-FU) is a common chemotherapeutic medication used to treat cancer. However, the intestinal tract may sustain oxidative damage as a result.

Objectives: The purpose of this study was to clarify the underlying molecular mechanisms and examine the preventive benefits of cereal-based fermented drinks (CFBs) against intestinal injury in mice caused by 5-FU.

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Ferroptosis, a novel form of cell death discovered in recent years, is typically accompanied by significant iron accumulation and lipid peroxidation during the process. This article systematically elucidates how tumor metabolic reprogramming affects the ferroptosis process in tumor cells. The paper outlines the basic concepts and physiological significance of tumor metabolic reprogramming and ferroptosis, and delves into the specific regulatory mechanisms of glucose metabolism, protein metabolism, and lipid metabolism on ferroptosis.

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Cucumber ( L.) is a crucial vegetable crop, requiring significant nitrogen fertilizer inputs. However, excessive nitrogen application not only impairs growth but also poses severe environmental risks.

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MODE: Minimax Optimal Deterministic Experiments for Causal Inference in the Presence of Covariates.

Entropy (Basel)

November 2024

National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), School of Statistics and Data Science, Nankai University, Tianjin 300071, China.

Data-driven decision-making has become crucial across various domains. Randomization and re-randomization are standard techniques employed in controlled experiments to estimate causal effects in the presence of numerous pre-treatment covariates. This paper quantifies the worst-case mean squared error of the difference-in-means estimator as a generalized discrepancy of covariates between treatment and control groups.

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Multiple sequence alignment (MSA) has evolved into a fundamental tool in the biological sciences, playing a pivotal role in predicting molecular structures and functions. With broad applications in protein and nucleic acid modeling, MSAs continue to underpin advancements across a range of disciplines. MSAs are not only foundational for traditional sequence comparison techniques but also increasingly important in the context of artificial intelligence (AI)-driven advancements.

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Age-related macular degeneration (AMD) is a leading cause of vision loss in the elderly, significantly diminishing quality of life. Currently, there is no available treatment to reverse retinal degeneration and neuronal loss, prompting a focus on interventions that slow the progression of intermediate AMD and geographic atrophy. Berries are rich in bioactive compounds, including flavonoids, anthocyanins, carotenoids, and resveratrol, known for their antioxidant, anti-inflammatory, and anti-angiogenic properties.

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Microbially mediated iron redox processes for carbon and nitrogen removal from wastewater: Recent advances.

Bioresour Technol

January 2025

Key Laboratory of Agro-Forestry Environmental Processes and Ecological Regulation of Hainan Province, School of Environmental Science and Engineering, Hainan University, 58 Renmin Avenue, Meilan District, Haikou 570228, China. Electronic address:

Article Synopsis
  • Iron is a key player in various microbial processes related to iron redox that impact global carbon and nitrogen cycles.
  • These processes include dissimilatory iron reduction, ammonium oxidation linked to iron reduction, and others that involve essential microorganisms and unique reaction mechanisms.
  • The review highlights potential applications in wastewater treatment, identifies research gaps, and suggests future directions for developing cost-effective and eco-friendly iron-based treatment methods.
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A butterfly-shaped acceptor with rigid skeleton and unique assembly enables both efficient organic photovoltaics and high-speed organic photodetectors.

Natl Sci Rev

January 2025

State Key Laboratory of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, The Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer Materials, Institute of Polymer Chemistry, Renewable Energy Conversion and Storage Center (RECAST), Tianjin Key Laboratory of Functional Polymer Materials, Nankai University, Tianjin 300071, China.

It remains challenging to design efficient bifunctional semiconductor materials in organic photovoltaic and photodetector devices. Here, we report a butterfly-shaped molecule, named WD-6, which exhibits low energy disorder and small reorganization energy due to its enhanced molecular rigidity and unique assembly with strong intermolecular interaction. The binary photovoltaic device based on PM6:WD-6 achieved an efficiency of 18.

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sp-carbon-linked covalent organic frameworks (spc-COFs) are crystalline porous polymers with repeat organic units linked by sp carbons, and have attracted increasing interest due to their robust skeleton and tunable semiconducting properties. Single-crystalline spc-COFs with well-defined structures can represent an ideal platform for investigating fundamental physics properties and device performance. However, the robust olefin bonds inhibit the reversible-reaction-based crystal self-correction, thus yielding polycrystalline or amorphous polymers.

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