Identification of assembly mode of non-canonical BAF (ncBAF) chromatin remodeling complex core module.

Mammalian SWI/SNF (mSWI/SNF) ATP-dependent chromatin remodeling complexes play critical roles in regulating gene expression and DNA accessibility, and more than 20 % of cancers have mutations in genes encoding chromatin remodeling complexes. The mSWI/SNF family comprises three distinct classes: canonical BAF (cBAF), PBAF, and non-canonical BAF (ncBAF). While the structures of cBAF and PBAF have been resolved by using cryo-electron microscopy (cryo-EM), the modular organization and assembly mechanism of ncBAF remain poorly understood.

M13 bacteriophage based fluorescence immunoassay against food allergens of Ara h 3 and Mac i 1.

Food allergy is increasingly prevalent and poses notable health risks, which underscores the urgent need to develop reliable and sensitive detection methods for effective identification of food allergens. This study aims to address the limitations of existing methods by developing an immunoassay utilizing bacteriophage/carbon dots (CDs)@silica core-shell nanospheres. Two CDs with different emission wavelengths (513 nm for Green CDs, 645 nm for Red CDs) were synthesized for signal development and amplification.

HMOX1-LDHB interaction promotes ferroptosis by inducing mitochondrial dysfunction in foamy macrophages during advanced atherosclerosis.

Advanced atherosclerosis is the pathological basis for acute cardiovascular events, with significant residual risk of recurrent clinical events despite contemporary treatment. The death of foamy macrophages is a main contributor to plaque progression, but the underlying mechanisms remain unclear. Bulk and single-cell RNA sequencing demonstrated that massive iron accumulation in advanced atherosclerosis promoted foamy macrophage ferroptosis, particularly in low expression of triggering receptor expressed on myeloid cells 2 (TREM2) foamy macrophages.

Efficient Orthogonal Spin Labeling of Proteins via Aldehyde Cyclization for Pulsed Dipolar EPR Distance Measurements.

Pulsed dipolar electron paramagnetic resonance (PD-EPR) measurement is a powerful technique for characterizing the interactions and conformational changes of biomolecules. The extraction of these distance restraints from PD-EPR experiments relies on manipulation of spin-spin pairs. The orthogonal spin labeling approach offers unique advantages by providing multiple distances between different spin-spin pairs.

α-decay half-life predictions with support vector machine.

In this study, we investigate the application of support vector machines utilizing a radial basis function kernel for predicting nuclear α-decay half-lives. Our approach integrates a comprehensive set of physics-derived features, including characteristics derived from nuclear structure, to systematically evaluate their impact on predictive accuracy. In addition to traditional parameters such as proton and neutron numbers, as well as terms based on the liquid drop model (e.

ROS scavenging and corneal epithelial wound healing by a self-crosslinked tissue-adhesive hydrogel based-on dual-functionalized hyaluronic acid.

Reactive oxygen species (ROS) scavenging is a viable approach to promote corneal epithelium wound healing. This study created a single-component hydrogel (HA Gel) with a novel dual-functionalized hyaluronic acid derivative (HA-GA-PBA) containing gallol and phenylboronic acid (PBA) moieties. Both of these moieties were dual-functional.

Light intensity-regulated glycogen synthesis and pollutant removal in microalgal-bacterial granular sludge for wastewater treatment.

As light intensity plays a pivotal role in the microalgal-bacterial granular sludge (MBGS) process, understanding its impact on system performance and energy dynamics is essential. This study investigated the effects of varying light intensities (20, 100, 200, and 300 μ mol/m²/s) on the performance of MBGS in urban wastewater treatment, with a particular focus on glycogen accumulation and pollutant removal. The results demonstrated that light intensity significantly influenced microbial community structure, glycogen accumulation, and pollutant removal efficiency.

Structure-Activity Relationship Study of Majusculamide D: Overcoming Metabolic Instability and Severe Toxicity with a Fluoro Analogue.

Majusculamide D, isolated from the marine cyanobacterium , is an anticancer lipopentapeptide consisting of fatty acid, tripeptide, and pyrrolyl proline moieties. In this work, by utilizing a convergent synthetic approach, late-stage modification, and bioisostere strategy, 26 majusculamide D analogues were synthesized, and two ( and ) demonstrated IC values < 1 nM against PANC-1 cancer cells. The results summarized a preliminary structure-activity relationship mainly at the C23, C4, C34, and C10 sites.

Surface-Enhanced Raman Spectroscopic Study of Key Intermediates in Electrochemical Ammonia Decomposition.

Ammonia is an alternative hydrogen storage material and a promising source of sustainable clean energy. The lack of a mechanistic understanding of ammonia electrooxidation hinders the efforts to overcome the slow kinetics of the anode reaction in direct ammonia fuel cells. Herein, we use surface-enhanced Raman spectroscopy to study the electro-decomposition of ammonia on the Au surface.

Manipulating Toughness and Microstructure in Polyelectrolyte Complex Hydrogels with Competitive Surfactant Micelles.

Polyelectrolyte complex (PEC) hydrogels provide a promising strategy to develop a class of physically cross-linked networks characterized by exceptional toughness and self-healing properties. However, the precise control of the microstructure and the enhancement of mechanical properties still pose challenges in the field of PEC hydrogels. Herein, we propose a strategy to manipulate the structure of PEC with competitively charged surfactant micelles, leveraging the spatially confined surface charge and excluded volume effects to overcome coacervation issues associated with the PEC, thus achieving a simple one-step preparation of macroscopically uniform and tough PEC hydrogels.

Target and Nontarget Analysis of Organophosphorus Flame Retardants and Plasticizers in a River Impacted by Industrial Activity in Eastern China.

Industrial activities are a major source of organophosphorus flame retardants (OPFRs) and plasticizers in aquatic environments. This study investigated the distribution of 40 OPFRs in a river impacted by major industrial manufacturing plants in Eastern China by target analysis. Nontarget analysis using high-resolution mass spectrometry was further employed to identify novel organophosphorus compounds (NOPs).

Regulation mechanism of the long-chain -alkane monooxygenase gene in RAG-1.

Unlabelled: As toxic pollutants, -alkanes are pervasively distributed in most environmental matrices. Although the alkane monooxygenase AlmA plays a critical role in the metabolic pathway of solid long-chain -alkanes (≥C) that are extremely difficult to degrade, the mechanism regulating this process remains unclear. Here, we characterized the function of AlmA in RAG-1, which was mainly involved in the degradation of long-chain -alkanes (C-C), among which, -C induced the promoter activity most.

Isomerism Effect of 3D Dimeric Acceptors for Non-Halogenated Solvent-Processed Organic Solar Cells with 20 % Efficiency.

Organic photovoltaic materials that can be processed via non-halogenated solvents are crucial for the large-area manufacturing of organic solar cells (OSCs). However, the limited available of electron acceptors with adequate solubility and favorable molecular packing presents a challenge in achieving efficient non-halogenated solvent-processed OSCs. Herein, inspired by the three-dimensional dimeric acceptor CH8-4, we employed a molecular isomerization strategy to synthesize its isomers, CH8-4A and CH8-4B, by tuning the position of fluorine (F) atom in the central unit.

Case report: A successful live birth after fertilization and embryo transfer in a patient with endometrial cancer who was treated conservatively.

Objective: To describe a patient conceiving with fertilization and embryo transfer(IVF-ET) after conservative treatment of early stage endometrial cancer.

Patient: A 31-year-old multiparous woman diagnosed with highly-differentiated (G1) endometrial adenocarcinoma (grade IA).

Interventions: After four courses of conservative treatment each followed by hysteroscopic biopsy and endometrial curettage,assisted reproductive technology was performed.

Observed Effects on Very Early Pregnancy Linked to Ambient PM Exposure in China among Women Undergoing Fertilization-Embryo Transfer.

The adverse effect of ambient PM exposure on very early pregnancy (VEP) remains controversial among epidemiological studies but is supported by toxicological evidence. We adopted a multicenter retrospective cohort of 141,040 cycles to evaluate the effect of PM exposure on the VEP using the fertilization and embryo transfer platform and high-resolution PM data in China. We first investigated the association between PM exposure 1 week before and 1 week after the embryo transfer date and VEP.

Valorization systems based on electrocatalytic nitrate/nitrite conversion for energy supply and valuable product synthesis.

The excessive accumulation of nitrate/nitrite (NO ) in surface and groundwater has severely disrupted the global nitrogen cycle and jeopardized public health. The electrochemical conversion of NO to ammonia (NH) not only holds promise for ecofriendly NO removal, but also provides a green alternative to the energy-intensive Haber-Bosch process for NH production. Recently, in addition to the electrocatalyst design explosion in this field, many innovative valorization systems based on NO -to-NH conversion have been developed for generating energy and expanding the range of value-added products.

Magnetic Domain Wall Energy Landscape Engineering in a Ferrimagnet.

Architectures based on a magnetic domain wall (DW) can store and process information at a high speed in a nonvolatile manner with ultra-low power consumption. Recently, transition-metal rare earth metal alloy-based ferrimagnets have attracted a considerable amount of attention for the ultrafast current-driven DW motion. However, the high-speed DW motion is subject to film inhomogeneity and device edge defects, causing challenges in controlling the DW motion and hindering practical application.

Automatic MRI-TRUS Fusion Technique for Transperineal Biopsy Guidance: From Preoperative Planning to Intraoperative Navigation.

Background: Targeted and systematic transperineal biopsy of lesions guided by magnetic resonance imaging (MRI) and transrectal ultrasonography (TRUS) fusion technique may optimize the biopsy procedure and enhance the detection of prostate cancer. We described the transperineal biopsy guided by an automatic MRI-TRUS fusion technique, and evaluated the accuracy and feasibility of this method in a prospective single-center study.

Methods: The proposed method focuses on automating the delineation of prostate contours in both the MRI and TRUS images, the registration and fusion of MRI and TRUS images, the generation and visualiztion of the systematic biopsy cores in their corresponding locations within the 2D and the 3D views, as well as the computation and visualiztion of needle trajectories from preoperative planning to intraoperative navigation.

Crystalline Silylene-Stabilized Diboryne and Siladiborirene.

The exploration of main group compounds with multiple bonds has significantly enhanced our understanding of chemical bonding and expanded transition-metal-free bond activation and catalysis. Diborynes, characterized by a boron-boron triple bond (B≡B), represent a particularly challenging area due to boron's limited valence electrons. Here, we report the synthesis and characterization of a silylene-stabilized diboryne (), expanding the frontier of diboryne stabilization.

Assembling MOF on CNTs into 0D-1D heterostructures for enhanced volatile organic compounds detection.

The rapid advancement of the Internet of Things has created a substantial demand for portable gas sensors. Nevertheless, the development of gas sensors that can fulfill the demanding criteria of high sensitivity and rapid response time continues to pose a considerable challenge. Herein, an in-situ anchoring strategy is proposed to construct CNTs@MOF heterostructure to establish strong electronic coupling and charge relocation for enhancing the monitoring capabilities of isopropanol (freshness markers for fruits) at room temperature.

Nanoenzymes-Integrated and Microenvironment Self-Adaptive Hydrogel for the Healing of Burn Injury and Post-Burn Depression.

Burn injuries often cause prolonged oxidative stress and inflammatory pain due to an initial increase in inflammatory responses, consequently exacerbating depressive disorders and severely impairing patients' quality of life. The primary function of traditional burn dressings is to prevent infection and facilitate tissue repair. However, these dressings are not intended for the inflammatory pain and depression that often occur during recovery.

Enhanced Water Splitting Electrocatalysis with Heterointerfacial Cobalt Phosphide In Situ Supported on a Cellulose-Derived Carbon Aerogel.

The active site density, intrinsic activity, and supporting substrate of cobalt phosphide catalysts are vital to their performance in alkaline water electrolysis. In this work, a CoP/CoP loaded on cellulose nanofiber-derived carbon aerogels (CP/CCAs) bifunctional electrocatalyst with a three-dimensional network and heterostructure is illustrated through sequential facile hydrothermal, freeze-drying, and phosphorylation processes. The three-dimensional network of carbon aerogels derived from cellulose nanofibers reveals a specific surface area of 183.

Current trends and hotspots of etiology of auditory neuropathy in the past 30 years: A bibliometric analysis.

Objective: To make an overview of global research trends in the etiology of auditory neuropathy (AN) over the past 30 years using a bibliometric approach.

Methods: Bibliometric analyses were conducted by GraphPad Prism 9.0, Citespace 6.

Machine learning helps reveal key factors affecting tire wear particulate matter emissions.

Tire wear particles (TWPs) are generated with every rotation of the tire. However, obtaining TWPs under real driving conditions and revealing key factors affecting TWPs are challenging. In this study, we obtained a TWPs dataset by simulating tire wear process under real driving conditions using a tire wear simulator and custom-designed test conditions.