Target and Nontarget Analysis of Organophosphorus Flame Retardants and Plasticizers in a River Impacted by Industrial Activity in Eastern China.

Industrial activities are a major source of organophosphorus flame retardants (OPFRs) and plasticizers in aquatic environments. This study investigated the distribution of 40 OPFRs in a river impacted by major industrial manufacturing plants in Eastern China by target analysis. Nontarget analysis using high-resolution mass spectrometry was further employed to identify novel organophosphorus compounds (NOPs).

Regulation mechanism of the long-chain -alkane monooxygenase gene in RAG-1.

Unlabelled: As toxic pollutants, -alkanes are pervasively distributed in most environmental matrices. Although the alkane monooxygenase AlmA plays a critical role in the metabolic pathway of solid long-chain -alkanes (≥C) that are extremely difficult to degrade, the mechanism regulating this process remains unclear. Here, we characterized the function of AlmA in RAG-1, which was mainly involved in the degradation of long-chain -alkanes (C-C), among which, -C induced the promoter activity most.

Isomerism Effect of 3D Dimeric Acceptors for Non-halogenated Solvent-Processed Organic Solar Cells with 20% Efficiency.

Organic photovoltaic materials that can be processed via non-halogenated solvents are crucial for the large-area manufacturing of organic solar cells (OSCs). However, the limited available of electron acceptors with adequate solubility and favorable molecular packing presents a challenge in achieving efficient non-halogenated solvent-processed OSCs. Herein, inspired by the three-dimensional dimeric acceptor CH8-4, we employed a molecular isomerization strategy to synthesize its isomers, CH8-4A and CH8-4B, by tuning the position of fluorine (F) atom in the central unit.

Case report: A successful live birth after fertilization and embryo transfer in a patient with endometrial cancer who was treated conservatively.

Objective: To describe a patient conceiving with fertilization and embryo transfer(IVF-ET) after conservative treatment of early stage endometrial cancer.

Patient: A 31-year-old multiparous woman diagnosed with highly-differentiated (G1) endometrial adenocarcinoma (grade IA).

Interventions: After four courses of conservative treatment each followed by hysteroscopic biopsy and endometrial curettage,assisted reproductive technology was performed.

Observed Effects on Very Early Pregnancy Linked to Ambient PM Exposure in China among Women Undergoing Fertilization-Embryo Transfer.

The adverse effect of ambient PM exposure on very early pregnancy (VEP) remains controversial among epidemiological studies but is supported by toxicological evidence. We adopted a multicenter retrospective cohort of 141,040 cycles to evaluate the effect of PM exposure on the VEP using the fertilization and embryo transfer platform and high-resolution PM data in China. We first investigated the association between PM exposure 1 week before and 1 week after the embryo transfer date and VEP.

Valorization systems based on electrocatalytic nitrate/nitrite conversion for energy supply and valuable product synthesis.

The excessive accumulation of nitrate/nitrite (NO ) in surface and groundwater has severely disrupted the global nitrogen cycle and jeopardized public health. The electrochemical conversion of NO to ammonia (NH) not only holds promise for ecofriendly NO removal, but also provides a green alternative to the energy-intensive Haber-Bosch process for NH production. Recently, in addition to the electrocatalyst design explosion in this field, many innovative valorization systems based on NO -to-NH conversion have been developed for generating energy and expanding the range of value-added products.

Magnetic Domain Wall Energy Landscape Engineering in a Ferrimagnet.

Architectures based on a magnetic domain wall (DW) can store and process information at a high speed in a nonvolatile manner with ultra-low power consumption. Recently, transition-metal rare earth metal alloy-based ferrimagnets have attracted a considerable amount of attention for the ultrafast current-driven DW motion. However, the high-speed DW motion is subject to film inhomogeneity and device edge defects, causing challenges in controlling the DW motion and hindering practical application.

Automatic MRI-TRUS Fusion Technique for Transperineal Biopsy Guidance: From Preoperative Planning to Intraoperative Navigation.

Background: Targeted and systematic transperineal biopsy of lesions guided by magnetic resonance imaging (MRI) and transrectal ultrasonography (TRUS) fusion technique may optimize the biopsy procedure and enhance the detection of prostate cancer. We described the transperineal biopsy guided by an automatic MRI-TRUS fusion technique, and evaluated the accuracy and feasibility of this method in a prospective single-center study.

Methods: The proposed method focuses on automating the delineation of prostate contours in both the MRI and TRUS images, the registration and fusion of MRI and TRUS images, the generation and visualiztion of the systematic biopsy cores in their corresponding locations within the 2D and the 3D views, as well as the computation and visualiztion of needle trajectories from preoperative planning to intraoperative navigation.

Crystalline Silylene-Stabilized Diboryne and Siladiborirene.

The exploration of main group compounds with multiple bonds has significantly enhanced our understanding of chemical bonding and expanded transition-metal-free bond activation and catalysis. Diborynes, characterized by a boron-boron triple bond (B≡B), represent a particularly challenging area due to boron's limited valence electrons. Here, we report the synthesis and characterization of a silylene-stabilized diboryne (), expanding the frontier of diboryne stabilization.

Assembling MOF on CNTs into 0D-1D heterostructures for enhanced volatile organic compounds detection.

The rapid advancement of the Internet of Things has created a substantial demand for portable gas sensors. Nevertheless, the development of gas sensors that can fulfill the demanding criteria of high sensitivity and rapid response time continues to pose a considerable challenge. Herein, an in-situ anchoring strategy is proposed to construct CNTs@MOF heterostructure to establish strong electronic coupling and charge relocation for enhancing the monitoring capabilities of isopropanol (freshness markers for fruits) at room temperature.

Nanoenzymes-Integrated and Microenvironment Self-Adaptive Hydrogel for the Healing of Burn Injury and Post-Burn Depression.

Burn injuries often cause prolonged oxidative stress and inflammatory pain due to an initial increase in inflammatory responses, consequently exacerbating depressive disorders and severely impairing patients' quality of life. The primary function of traditional burn dressings is to prevent infection and facilitate tissue repair. However, these dressings are not intended for the inflammatory pain and depression that often occur during recovery.

Enhanced Water Splitting Electrocatalysis with Heterointerfacial Cobalt Phosphide In Situ Supported on a Cellulose-Derived Carbon Aerogel.

The active site density, intrinsic activity, and supporting substrate of cobalt phosphide catalysts are vital to their performance in alkaline water electrolysis. In this work, a CoP/CoP loaded on cellulose nanofiber-derived carbon aerogels (CP/CCAs) bifunctional electrocatalyst with a three-dimensional network and heterostructure is illustrated through sequential facile hydrothermal, freeze-drying, and phosphorylation processes. The three-dimensional network of carbon aerogels derived from cellulose nanofibers reveals a specific surface area of 183.

Current trends and hotspots of etiology of auditory neuropathy in the past 30 years: A bibliometric analysis.

Objective: To make an overview of global research trends in the etiology of auditory neuropathy (AN) over the past 30 years using a bibliometric approach.

Methods: Bibliometric analyses were conducted by GraphPad Prism 9.0, Citespace 6.

Machine learning helps reveal key factors affecting tire wear particulate matter emissions.

Tire wear particles (TWPs) are generated with every rotation of the tire. However, obtaining TWPs under real driving conditions and revealing key factors affecting TWPs are challenging. In this study, we obtained a TWPs dataset by simulating tire wear process under real driving conditions using a tire wear simulator and custom-designed test conditions.

Assembly of Four Ternary Polyoxometalate Aggregates by Integrating Presynthesized {XWNbO} (X = Si/Ge) Units Using Molybdenum-Oxo Clusters.

Polyoxometalates (POMs) have good potential for applications in different fields, including conducting materials, optics, and electrocatalysis. Of particular significance is the synthesis and development of addendum POMs. Molybdenum-oxo clusters, which are renowned for their diverse structures and electronic properties, were utilized to facilitate the synthesis of innovative materials.

Enantioselective Vinylogous Addition of Enones to Allenes Enabled by Synergistic Borane/Palladium Catalysis.

Herein, we report a method for enantioselective vinylogous addition of enones to alkoxyallenes enabled by synergistic borane/palladium catalysis. The inductive effect provided by borane coordination to the ketone was essential for closing the gap between the conditions needed for the generation of a dienolate and those needed for initiation of the palladium catalytic cycle by protonation of the metal catalyst. Furthermore, we accomplished the first example of stereodivergent synthesis with chiral borane/transition-metal catalysts.

Dual-purpose elemental sulfur for capturing and accelerating biodegradation of petroleum hydrocarbons in anaerobic environment.

Hydrophobic organic pollutants in aqueous environments are challenging to biodegrade due to limited contact between microorganisms, the pollutants and the electron acceptor, particularly under anaerobic or anoxic conditions. Here, we propose a novel strategy that uses inexpensive, dual-function elemental sulfur (S) to enhance biodegradation. Using petroleum hydrocarbons as the target pollutants, we demonstrated that hydrophobic and nonpolar S° can concentrate hydrocarbons while simultaneously serving as an electron acceptor to enrich hydrocarbon-degrading bacteria.

Single-Cell RNA Sequencing Reveals That C5AR1 in Follicle Monocyte Cells Could Predict the Development of POI.

Purpose: To investigate the follicle microenvironments of women with premature ovarian insufficiency (POI), with normal ovarian reserve function, and who are older (age >40 years) and to identify potential therapeutic targets.

Patients And Methods: In total, 9 women who underwent in vitro fertilization(IVF) or intracytoplasmic sperm injection(ICSI) were included in this study. The first punctured follicle of each patient was used.

Development of a prediction nomogram for IgG levels among asymptomatic or mild patients with COVID-19.

Objective: COVID-19 has evolved into a seasonal coronavirus disease, characterized by prolonged infection duration and repeated infections, significantly increasing the risk of patients developing long COVID. Our research focused on the immune responses in asymptomatic and mild cases, particularly the critical factors influencing serum immunoglobulin G (IgG) levels and their predictive value.

Methods: We conducted a retrospective analysis on data from 1939 asymptomatic or mildly symptomatic COVID-19 patients hospitalized between September 2022 and June 2023.

Higher remnant cholesterol increases the risk of coronary heart disease and diabetes in postmenopausal women.

Background: Postmenopausal women represent the demographic increasingly susceptible to cardiovascular and metabolic diseases. Elevated levels of remnant cholesterol (RC) have been implicated in atherosclerosis and insulin resistance.

Methods: This study aimed to investigate the relationship between RC and the prevalence of coronary heart disease (CHD), diabetes, and CHD combined with diabetes in a nationally representative sample of US postmenopausal women using data from the National Health and Nutrition Examination Survey (NHANES) 2007-2018.

Therapeutic potential of CD73 mesenchymal stem cells for myocardial infarction and beyond.

Extracellular adenine nucleotides serve as crucial signaling molecules and influence a broad spectrum of physiological and pathological processes. CD73, the rate-limiting enzyme in the metabolism of extracellular adenine nucleotides, is ubiquitously expressed on various cell types, particularly stem cells. CD73 mesenchymal stem cells (MSCs) have emerged as promising candidates for therapeutic applications due to their immunomodulatory and pro-regenerative properties.

A novel self-assembling peptide nanofiber hydrogel with glucagon-like peptide-1 functionality enhances islet survival to improve islet transplantation outcome in diabetes treatment.

Islet transplantation is a promising therapy for diabetes, yet the limited survival and functionality of transplanted islet grafts hinder optimal outcomes. Glucagon-like peptide-1 (GLP-1), an endogenous hormone, has shown potential to enhance islet survival and function; however, its systemic administration can result in poor localization and undesirable side effects. To address these challenges, we developed a novel peptide-based nanofiber hydrogel incorporating GLP-1 functionality for localized delivery.

Manipulating π-π Interactions between Single Molecules by Using Antenna Electrodes as Optical Tweezers.

Via conductance measurements of thousands of single-molecule junctions, we report that the π-π coupling between neighboring aromatic molecules can be manipulated by laser illumination. We reveal that this optical manipulation originates from the optical plasmonic gradient force generated inside the nanogaps, in which the gapped antenna electrodes act as optical tweezers pushing the neighboring molecules closer together. These findings offer a nondestructive approach to regulate the interaction of the molecules, deepening the understanding of the mechanism of π-π interaction, and open an avenue to manipulate the relative position of extremely small objects down to the scale of single molecules.

Supramolecular Assembly Enhanced Linear and Nonlinear Chiroptical Properties of Chiral Manganese Halides.

Chiral hybrid organic-inorganic metal halides (HOMHs) hold great promise in broad applications ranging from ferroelectrics, spintronics to nonlinear optics, owing to their broken inversion symmetry and tunable chiroptoelectronic properties. Typically, chiral HOMHs are constructed by chiral organic cations and metal anion polyhedra, with the latter regarded as optoelectronic active units. However, the primary design approaches are largely constrained to regulation of general components within structural formula.