Efficacy and safety of crizotinib plus bevacizumab in positive non-small cell lung cancer: an open-label, single-arm, prospective observational study.

Background: Crizotinib is a tyrosine kinase inhibitor (TKI) effective in positive non-small cell lung cancer (NSCLC) patients. Bevacizumab is an antiangiogenic monoclonal antibody, and improves clinical benefit of NSCLC in combination with EGFR-TKIs or chemotherapy. However, the efficacy and safety of crizotinib plus bevacizumab in treating naive positive NSCLC patients have not been studied.

Reactive Oxygen Species-Responsive Adaptable Self-Assembly of Peptides toward Advanced Biomaterials.

Precise control over self-assembly of peptides into adaptable nanostructures allows for emulating the dynamic organization of natural proteins and their sophisticated biological functions. Utilization of disease biomarkers as internal stimuli for manipulating the self-assembly of peptides bestows their adaptable features with a spatiotemporal resolution to satisfy the requirement of the performance of biomaterials. Reactive oxygen species (ROS) consisting of reactive ions or free radicals are overexpressed by pathological lesions and have been recognized as one of conventional biomarkers for disease progression.

Peptide Tectonics: Encoded Structural Complementarity Dictates Programmable Self-Assembly.

Programmable self-assembly of peptides into well-defined nanostructures represents one promising approach for bioinspired and biomimetic synthesis of artificial complex systems and functional materials. Despite the progress made over the past two decades in the development of strategies for precise manipulation of the self-assembly of peptides, there is a remarkable gap between current peptide assemblies and biological systems in terms of structural complexity and functions. Here, the concept of peptide tectonics for the creation of well-defined nanostructures predominately driven by the complementary association at the interacting interfaces of tectons is introduced.

KPO-promoted domino reactions: diastereoselective synthesis of -2,3-dihydrobenzofurans from salicyl -butanesulfinyl imines and sulfur ylides.

An efficient domino annulation between sulfur ylides and salicyl -butylsulfinyl imines was developed. The reaction proceeds with a diastereodivergent process, the configuration of the sulfinyl group determining the stereochemical course of the reaction. The method allows the synthesis of a highly substituted -2,3-dihydrobenzofuran skeleton with high yield and good chemo- and diastereoselectivity.