1 results match your criteria: "Nankai University Tianjin 300071 PR China tanganna@nankai.edu.cn kongdem@nankai.edu.cn.[Affiliation]"
Telomerase-activated Au@DNA nanomachine for targeted chemo-photodynamic synergistic therapy.
RSC Med Chem
November 2023
State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Centre for Analytical Sciences, College of Chemistry, Nankai University Tianjin 300071 PR China
We successfully designed a smart activatable nanomachine for cancer synergistic therapy. Photodynamic therapy (PDT) and chemotherapy can be activated by intracellular telomerase while anti-cancer drugs can be effectively transported into tumour cells. An Sgc8 aptamer was designed, which can specifically distinguish tumour cells from normal cells and perform targeted therapy.
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