Spiropyran-modified upconversion nanocomposite as a fluorescent sensor for diagnosis of histidinemia.

Histidinemia is a congenital metabolic disorder where the histidine (His) metabolism is blocked, resulting in increased concentrations of His in blood and urine. The disease causes an abnormal development of the patient's nervous system, which leads to many serious illnesses. Therefore, it is very important to diagnose early.