Novel Janus MoSiGeN nanosheet: adsorption behaviour and sensing performance for NO and NO gas molecules.

A novel Janus MoSiGeN nanosheet is proposed for detecting poisonous gas molecules. Herein, the adsorption behaviour and sensing performance of both sides of the MoSiGeN monolayer to NO and NO gas molecules were investigated by first-principles calculations. Firstly, it is found that the MoSiGeN monolayer exhibits structural stability and indirect gap semiconductor characteristics.

Integrated bioactive scaffold with aptamer-targeted stem cell recruitment and growth factor-induced pro-differentiation effects for anisotropic meniscal regeneration.

Reconstruction of the knee meniscus remains a significant clinical challenge owing to its complex anisotropic tissue organization, complex functions, and limited healing capacity in the inner region. The development of in situ tissue-engineered meniscal scaffolds, which provide biochemical signaling to direct endogenous stem/progenitor cell (ESPC) behavior, has the potential to revolutionize meniscal tissue engineering. In this study, a fiber-reinforced porous scaffold was developed based on aptamer Apt19S-mediated mesenchymal stem cell (MSC)-specific recruitment and dual growth factor (GF)-enhanced meniscal differentiation.

Subcomponent self-assembly of circular helical Dy(L) and bipyramid Dy(L) architectures directed second-order template effects.

metal-templated (hydrazone) condensation also called subcomponent self-assembly of 4,6-dihydrazino-pyrimidine, -vanillin and dysprosium ions resulted in the formation of discrete hexa- or dodecanuclear metallosupramolecular Dy(L) or Dy(L) aggregates resulting from second-order template effects of the base and the lanthanide counterions used in these processes. XRD analysis revealed unique circular helical or tetragonal bipyramid architectures in which the bis(hydrazone) ligand L adopts different conformations and shows remarkable differences in its mode of metal coordination. While a molecule of trimethylamine acts as a secondary template that fills the void of the Dy(L) assembly, sodium ions take on this role for the formation of heterobimetallic Dy(L) by occupying vacant coordination sites, thus demonstrating that these processes can be steered in different directions upon subtle changes of reaction conditions.

Correction: Visible-light-mediated Minisci C-H alkylation of heteroarenes with unactivated alkyl halides using O as an oxidant.

[This corrects the article DOI: 10.1039/C8SC04892D.].

Higher benefit-risk ratio of COVID-19 vaccination in patients with schizophrenia and major depressive disorder versus patients with bipolar disorder when compared to controls.

Patients with major psychiatric disorders (MPD) that include schizophrenia (SCH), bipolar disorder (BP), and major depressive disorder (MDD) are at increased risk for coronavirus disease 2019 (COVID-19). However, the safety and efficacy of COVID-19 vaccines in MPD patients have not been fully evaluated. This study aimed to investigate adverse events (AEs)/side effects and efficacy of COVID-19 vaccines in MPD patients.

Introduction to 'Synthesis and chemical biology of macrocycles'.

Gong Chen, Monika Raj and Andrei Yudin introduce the themed collection on the 'Synthesis and chemical biology of macrocycles'.

A tunable full-color lanthanide noncovalent polymer based on cucurbituril-mediated supramolecular dimerization.

The construction of lanthanide multicolor luminescent materials with tunable photoluminescence properties has been developed as one of the increasingly significant topics and shown inventive applications in miscellaneous fields. However, fabricating such materials based on synergistically assembly-induced emission rather than simple blending of different fluorescent dyes together still remains a challenge. Herein, we report a europium-based noncovalent polymer with tunable full-color emission, which is constructed from the 2,6-pyridinedicarboxylic acid-bearing bromophenylpyridinium salt.

Supramolecular assembly confined purely organic room temperature phosphorescence and its biological imaging.

Purely organic room temperature phosphorescence, especially in aqueous solution, is attracting increasing attention owing to its large Stokes shift, long lifetime, low preparation cost, low toxicity, good processing performance advantages, and broad application value. This review mainly focuses on macrocyclic (cyclodextrin and cucurbituril) hosts, nanoassembly, and macromolecule (polyether) confinement-driven RTP. As an optical probe, the assembly and the two-stage assembly strategy can realize the confined purely organic RTP and achieve energy transfer and light-harvesting from fluorescence to delayed fluorescence or phosphorescence.

Rational design of a dual-reactive probe for imaging the biogenesis of both HS and GSH from l-Cys rather than d-Cys in live cells.

Biothiols and their interconversion are involved in cellular redox homeostasis as well as many physiological processes. Here, a dual-reactive dual-quenching fluorescent probe was rationally developed based on thiolysis reactions of 7-nitrobenzoxadiazole (NBD) tertiary amine and 7-cyanobenzoxadiazole (CBD) arylether for imaging of the biothiol interconversion. We demonstrate that the NBD-CBD probe exhibits very weak background fluorescence due to the dual-quenching effects, and can be dual-activated by HS and GSH with an over 500-fold fluorescence increase at 525 nm.

Iron-catalysed hydroalumination of internal alkynes.

Although research on iron-catalysed reactions has recently achieved significant progress, the activity and selectivity of iron catalysts are generally inferior to those of noble-metal catalysts. The development of new iron-catalysed reactions, especially those in which iron catalysts exhibit superior activity or selectivity to other catalysts, is the key to promote iron catalysis. Herein, we report the first protocol for iron-catalysed hydroalumination of internal alkynes.

Controlled synthesis of open-mouthed epitope-imprinted polymer nanocapsules with a PEGylated nanocore and their application for fluorescence detection of target protein.

Epitope imprinting is an effective way to create artificial receptors for protein recognition. Surface imprinting with immobilized templates and sacrificial supports can generate high-quality imprinted cavities of homogeneous orientation and good accessibility, but it is still challenging to fabricate nanoscale imprinted materials by this approach. Herein, we propose a method for the controlled synthesis of open-mouthed epitope-imprinted polymer nanocapsules (OM-MIP NCs) by limiting the imprinting polymerization on the template-bearing side of the Janus nanoparticles (JNPs).

Synthesis of MoS-based nanostructures and their applications in rechargeable ion batteries, catalysts and gas sensors: a review.

Molybdenum disulfide (MoS) is a two-dimensional (2D) layered material with a graphene-like structure that has attracted attention because of its large specific surface area and abundant active sites. In addition, the compounding of MoS with other materials can enhance the performance in applications such as batteries, catalysts, and optoelectronic devices, MoS is prepared by various methods, among which chemical deposition and hydrothermal methods are widely used. In this review, we focus on summarizing the applications of MoS and MoS composite nanomaterials in rechargeable ion batteries, catalysts for water splitting and gas sensors, and briefly outline the preparation methods.

Novel Risk Prediction Model to Determine Adverse Heart Failure Outcomes in Arrhythmogenic Right Ventricular Cardiomyopathy.

Background Patients with arrhythmogenic right ventricular cardiomyopathy are at risk for life-threatening ventricular tachyarrhythmias, but progressive heart failure (HF) may occur in later stages of disease. This study aimed to characterize potential risk predictors and develop a model for individualized assessment of adverse HF outcomes in arrhythmogenic right ventricular cardiomyopathy. Methods and Results Longitudinal and observational cohorts with 290 patients with arrhythmogenic right ventricular cardiomyopathy from the Fuwai Hospital in Beijing, China, and 99 patients from the University Heart Center in Zurich, Switzerland, with follow-up data were studied.

Synthesis and characterisation of the ternary intermetalloid clusters {M@[As(ZnMes)]} (M = Nb, Ta) from binary [M@As] precursors.

The development of rational synthetic routes to inorganic arsenide compounds is an important goal because these materials are finding applications in many areas of materials science. In this paper, we show that the binary crown clusters [M@As] (M = Nb, Ta) can be used as synthetic precursors which, when combined with ZnMes, generate ternary intermetalloid clusters with 12-vertex cages, {M@[As(ZnMes)]} (M = Nb, Ta). Structural studies are complemented by mass spectrometry and an analysis of the electronic structure using DFT.

New insights into the NH-selective catalytic reduction of NO over Cu-ZSM-5 as revealed by spectroscopy.

To control diesel vehicle NO emissions, Cu-exchanged zeolites have been applied in the selective catalytic reduction (SCR) of NO using NH as reductant. However, the harsh hydrothermal environment of tailpipe conditions causes irreversible catalyst deactivation. The aggregation of isolated Cu brings about unselective ammonia oxidation along with the main NH-SCR reaction.

Stereodivergent synthesis of enantioenriched azepino[3,4,5-]-indoles cooperative Cu/Ir-catalyzed asymmetric allylic alkylation and intramolecular Friedel-Crafts reaction.

The development of enantioselective annulation reactions using readily available substrates for the construction of structurally and stereochemically diverse heterocycles is a compelling topic in diversity-oriented synthesis. Herein, we report efficient catalytic asymmetric formal 1,3-dipolar (3 + 4) cycloadditions of azomethine ylides with 4-indolyl allylic carbonates for the construction of azepino[3,4,5-]-indoles fused with a challenging seven-membered N-heterocycle, a frequently occurring tricyclic indole scaffold in bioactive compounds and pharmaceuticals. Through cooperative Cu/Ir-catalyzed asymmetric allylic alkylation followed by intramolecular Friedel-Crafts reaction, an array of azepino[3,4,5-]-indoles were obtained in good yields with excellent diastereo-/enantioselective control.

An electrically conductive metallocycle: densely packed molecular hexagons with π-stacked radicals.

Electrical conduction among metallocycles has been unexplored because of the difficulty in creating electronic transport pathways. In this work, we present an electrocrystallization strategy for synthesizing an intrinsically electron-conductive metallocycle, [Ni(NDI-Hpz)(dma)(NO)]·5DMA·HO (PMC-hexagon) (NDI-Hpz = ,'-di(1-pyrazol-4-yl)-1,4,5,8-naphthalenetetracarboxdiimide). The hexagonal metallocycle units are assembled into a densely packed ABCABC… sequence (like the fcc geometry) to construct one-dimensional (1D) helical π-stacked columns and 1D pore channels, which were maintained under the liberation of HO molecules.

Mitogenomes provide new insights of evolutionary history of Boreheptagyiini and Diamesini (Diptera: Chironomidae: Diamesinae).

Mitogenomes have been widely used for phylogenetic reconstruction of various Dipteran groups, but specifically for chironomid, they have not been carried out to resolve the relationships. Diamesinae (Diptera: Chironomidae) are important bioindicators for freshwater ecosystem monitoring, but its evolutionary history remains uncertain for lack of information. Here, coupled with one previously published and 30 new mitogenomes of Diamesinae, we carried out comparative mitogenomic analysis and phylogenetic analysis.

LGR4 cooperates with PrPc to endow the stemness of colorectal cancer stem cells contributing to tumorigenesis and liver metastasis.

Cancer stem cells (CSCs) are a subpopulation of cancer cells that drive tumour progression and metastasis. Anti-CSC strategies represent new targets for cancer therapies. However, CSCs are highly plastic and heterogeneous, making validation and targeting difficult without bona fide markers that define their identity, especially in a clinical setting.

MnO nanosheets as a carrier and accelerator for improved live-cell biosensing application of CRISPR/Cas12a.

Besides gene-editing, the CRISPR/Cas12a system has also been widely used in biosensing, but its applications in live-cell biosensing are rare. One reason is lacking appropriate carriers to synchronously deliver all components of the CRISPR/Cas12a system into living cells. Herein, we demonstrate that MnO nanosheets are an excellent carrier of CRISPR/Cas12a due to the two important roles played by them.

g-CN/ZnCdS heterojunction for efficient visible light-driven photocatalytic hydrogen production.

To suppress the aggregation behavior caused by the high surface energy of quantum dots (QDs), ZnCdS QDs were grown on a g-CN support. During the growth process, the QDs tightly adhered to the support surface. The ZnCdS QDs were prepared by low-temperature sulfurization and cation exchange with a zeolitic imidazolate framework precursor under mild conditions.

Synthesis of ppy-MgO-CNT nanocomposites for multifunctional applications.

Cotton is one of the most important raw materials for textile and clothing production. The main drawbacks of cotton fibers are their poor mechanical properties and high flammability. Compared with some synthetic polymer fibers, cotton fabrics treated with modern flame-retardant and reinforcement finishes often cannot meet rigid military specifications.

Realizing high performance flexible supercapacitors by electrode modification.

It is well known that the structure of an electrode material seriously affects its electrochemical performance. In this study, we prepare hybrid structured NiCoS@PPy nanoarchitectures by a hydrothermal method and subsequent electrodeposition process. The specific capacitance of the obtained sample is 1733.