Effect of LLZO on the polymerization of acrylate solid-state electrolytes on cathodes.

The comprehensive performance of the state-of-the-art solid-state electrolytes (SSEs) cannot match the requirements of commercial applications, and constructing an organic-inorganic composite electrolyte on a porous electrode is an effective coping strategy. However, there are few studies focused on the influence of inorganic ceramics on the polymerization of multi-organic components. In this study, it was found that the addition of LiLaZrTaO (LLZO) weakens the interaction between different polymers and makes organic and inorganic components contact directly in the solid electrolyte.

Theoretical prediction of the electronic structure, optical properties and photocatalytic performance of type-I SiS/GeC and type-II SiS/ZnO heterostructures.

Nowadays, it would be ideal to develop high-performance photovoltaic devices as well as highly efficient photocatalysts for the production of hydrogen photocatalytic water splitting, which is a feasible and sustainable energy source for addressing the challenges related to environmental pollution and a shortage of energy. In this work, we employ first-principles calculations to investigate the electronic structure, optical properties and photocatalytic performance of novel SiS/GeC and SiS/ZnO heterostructures. Our results indicate that both the SiS/GeC and SiS/ZnO heterostructures are structurally and thermodynamically stable at room temperature, suggesting that they are promising materials for experimental implementation.

Site-directed late-stage diversification of macrocyclic nannocystins facilitating anticancer SAR and mode of action studies.

Nannocystins are a family of 21-membered cyclodepsipeptides with excellent anticancer activity. However, their macrocyclic architecture poses a significant challenge to structure modification. Herein, this issue is addressed by leveraging the strategy of post-macrocyclization diversification.

Activation of perfluoroalkyl iodides by anions: extending the scope of halogen bond activation to C(sp)-H amidation, C(sp)-H iodination, and perfluoroalkylation reactions.

A simple, efficient, and convenient activation of perfluoroalkyl iodides by BuONa or KOH, without expensive photo- or transition metal catalysts, allows the promotion of versatile α-sp C-H amidation reactions of alkyl ethers and benzylic hydrocarbons, C-H iodination of heteroaryl compounds, and perfluoroalkylations of electron-rich π bonds. Mechanistic studies show that these novel protocols are based on the halogen bond interaction between perfluoroalkyl iodides and BuONa or KOH, which promote homolysis of perfluoroalkyl iodides under mild conditions.

An protonation-activated supramolecular self-assembly for selective suppression of tumor growth.

An supramolecular self-assembly in the subcellular organelles could provide a new strategy to treat diseases. Herein, we report a protonation-activated supramolecular self-assembly system in the lysosomes, which could destabilize the lysosome membrane, resulting in the selective suppression of cancer cells. In this system, pyridyl-functionalized tetraphenylethylene (TPE-Py) was protonated in the lysosomes of A549 lung cancer cells to form octahedron-like structures with cucurbit[8]uril (CB[8]), which impaired the integrity of the lysosome membrane, resulting in selective suppression of cancer cells.

Quantitative evaluation of the actual hydrogen atom donating activities of O-H bonds in phenols: structure-activity relationship.

The H-donating activity of phenol and the H-abstraction activity of phenol radicals have been extensively studied. In this article, the second-order rate constants of 25 hydrogen atom transfer (HAT) reactions between phenols and PINO and DPPH radicals in acetonitrile at 298 K were studied. Thermo-kinetic parameters Δ (XH) were obtained using a kinetic equation [Δ = Δ (XH) + Δ (Y)].

The anthropogenic effect of land use on population genetics of .

Since the beginning of the Holocene era, human activities have seriously impacted animal habitats and vegetative environments. Species that are dependent on natural habitats or with narrow niches might be more severely affected by habitat changes. is distributed in subtropical China and highly dependent on the mountain environment.

Highly bioresistant, hydrophilic and rigidly linked trityl-nitroxide biradicals for cellular high-field dynamic nuclear polarization.

Cellular dynamic nuclear polarization (DNP) has been an effective means of overcoming the intrinsic sensitivity limitations of solid-state nuclear magnetic resonance (ssNMR) spectroscopy, thus enabling atomic-level biomolecular characterization in native environments. Achieving DNP signal enhancement relies on doping biological preparations with biradical polarizing agents (PAs). Unfortunately, PA performance within cells is often limited by their sensitivity to the reductive nature of the cellular lumen.

Bacterial infection microenvironment-responsive porous microspheres by microfluidics for promoting anti-infective therapy.

The overuse of antibiotics for treating bacterial infection has caused severe bacterial resistance and become a public health threat worldwide. It is desired to develop novel antibiotic delivery systems as efficient antibacterial strategies for promoting anti-infective therapy. Herein, the AgNPs-loaded -[(2-hydroxy-3-trimethyl ammonium) propyl] chitosan (HTCC)/hyaluronic acid (HA) porous microspheres (HHPMs) by microfluidics have been developed as novel bacterial infection microenvironment (IME)-responsive antibiotic delivery systems for promoting antimicrobial therapy.

Alkylboronic acids as alkylating agents: photoredox-catalyzed alkylation reactions assisted by KPO.

Despite the ubiquity of alkylboronic acids in organic synthesis, their utility as alkyl radical precursors in visible-light-induced photocatalytic reactions is limited by their high oxidation potentials. In this study, we demonstrated that an inorganophosphorus compound can modulate the oxidation potentials of alkylboronic acids so that they can act as alkyl radical precursors. We propose a mechanism based on the results of fluorescence quenching experiments, electrochemical experiments, B and P NMR spectroscopy, and other techniques.

[Dissolution test and evaluation of Guizhi Fuling Capsules].

Because of the complex components, simple content determination can hardly reflect the overall quality of Guizhi Fuling Capsules. Therefore, it is necessary to carry out a multi-component dissolution test. The variability of quality among different batches of products from different manufacturers is a common problem of Chinese medicine solid preparations.

Precisely synthesized LiF-tipped CoF-nanorod heterostructures improve energy storage capacities.

CoF, with a relatively high theoretical capacity (553 mA h g), has been attracting increasing attention in the energy storage field. However, a facile and controllable synthesis of monodispersed CoF and CoF-based nano-heterostructures have been rarely reported. In this direction, an eco-friendly and precisely controlled colloidal synthesis strategy to grow uniformly sized CoF nanorods and LiF-tipped CoF-nanorod heterostructures based on a seeded-growth method is established.

Two-dimensional van der Waals heterostructures (vdWHs) with band alignment transformation in multi-functional devices.

Two-dimensional van der Waals heterostructures (vdWHs) with tunable band alignment have the potential to be benignant in the development of minimal multi-functional and controllable electronics, but they have received little attention thus far. It is crucial to characterize and control the band alignment in semiconducting vdWHs, which determines the electronic and optoelectronic properties. The future success of optoelectronic devices will require improved electronic property control techniques, such as using an external electric field or strain engineering, to change the electronic structures directly.

Enhanced cycling stability and rate capability of a graphene-supported commercialized Vat Blue 4 anode for advanced Li-ion batteries.

Commercialized Vat Blue 4 (VB4) has attracted more attention as a promising anode for large-scale applications in Li-ion batteries (LIBs) due to its high electrochemical activity, low price, and large-scale production. However, its moderate solubility results in severe capacity decay and low utilization of active components. Herein, we present a graphene-supported VB4 composite (VB4/rGO) prepared by a facile sonication and hydrothermal process for long cycling stability and high-rate capability.

Non-flammable, dilute, and hydrous organic electrolytes for reversible Zn batteries.

Rechargeable Zn batteries hold great practicability for cost-effective sustainable energy storage but suffer from irreversibility of the Zn anode in aqueous electrolytes due to parasitic H evolution, corrosion, and dendrite growth. Herein, we report a non-flammable, dilute, and hydrous organic electrolyte by dissolving low-cost hydrated Zn(ClO)·6HO in trimethyl phosphate (TMP), which homogenizes plating/stripping and enables formation of a Zn(PO)-ZnCl-rich interphase to stabilize the Zn anode. A dilute 0.

Bismuth nanoparticles embedded in a carbon skeleton as an anode for high power density potassium-ion batteries.

Bismuth is a promising anode for potassium-ion batteries (PIBs) due to its suitable redox potential, large theoretical capacity, and superior electronic conductivity. Herein, we report a Bi@C (Bi nanoparticles uniformly embedded in a carbon skeleton) composite anode which delivers a superior rate performance of 244.3 mA h g at 10.

Base-promoted cascade β-F-elimination/electrocyclization/Diels-Alder/retro-Diels-Alder reaction: efficient access to δ-carboline derivatives.

A serendipitous and highly efficient approach for the construction of a variety of δ-carboline derivatives was developed through base-promoted cascade β-F-elimination/electrocyclization/Diels-Alder/retro-Diels-Alder reaction of -2,2,2-trifluoroethylisatin ketoimine esters with alkynes in good to high yields with excellent regio-/chemoselectivity control. Moreover, a reasonable reaction pathway was proposed, which was in accordance with the prepared reaction intermediate and control experiment results. The δ-carboline product could be easily converted into a new chiral Py-box-type ligand through simple synthetic transformations.

A CRISPR/Cas12a-responsive dual-aptamer DNA network for specific capture and controllable release of circulating tumor cells.

The separation and detection of circulating tumor cells (CTCs) have a significant impact on clinical diagnosis and treatment by providing a predictive diagnosis of primary tumors and tumor metastasis. But the responsive release and downstream analysis of live CTCs will provide more valuable information about molecular markers and functional properties. To this end, specific capture and controllable release methods, which can achieve the highly efficient enrichment of CTCs with strong viability, are urgently needed.

Evaluation and comparison of antioxidant abilities of five bioactive molecules with C-H and O-H bonds in thermodynamics and kinetics.

In this work, the antioxidant abilities of NADH coenzyme analogue BNAH, F420 reduction prototype analogue F420H, vitamin C analogue iAscH, caffeic acid, and (+)-catechin in acetonitrile in chemical reactions were studied and discussed. Three physical parameters of the antioxidant XH, homolytic bond dissociation free energy Δ (XH), self-exchange HAT reaction activation free energy Δ , and thermo-kinetic parameter Δ (XH), were used to evaluate the antioxidant ability of XH in thermodynamics, kinetics, and thermo-kinetics. By comparing Δ (XH), Δ and Δ (XH) of these five bioactive antioxidants to release hydrogen atoms, it is easy to find that iAscH is the best hydrogen atom donor both thermodynamically and kinetically among these antioxidants.

Novel Janus MoSiGeN nanosheet: adsorption behaviour and sensing performance for NO and NO gas molecules.

A novel Janus MoSiGeN nanosheet is proposed for detecting poisonous gas molecules. Herein, the adsorption behaviour and sensing performance of both sides of the MoSiGeN monolayer to NO and NO gas molecules were investigated by first-principles calculations. Firstly, it is found that the MoSiGeN monolayer exhibits structural stability and indirect gap semiconductor characteristics.

Integrated bioactive scaffold with aptamer-targeted stem cell recruitment and growth factor-induced pro-differentiation effects for anisotropic meniscal regeneration.

Reconstruction of the knee meniscus remains a significant clinical challenge owing to its complex anisotropic tissue organization, complex functions, and limited healing capacity in the inner region. The development of in situ tissue-engineered meniscal scaffolds, which provide biochemical signaling to direct endogenous stem/progenitor cell (ESPC) behavior, has the potential to revolutionize meniscal tissue engineering. In this study, a fiber-reinforced porous scaffold was developed based on aptamer Apt19S-mediated mesenchymal stem cell (MSC)-specific recruitment and dual growth factor (GF)-enhanced meniscal differentiation.

Subcomponent self-assembly of circular helical Dy(L) and bipyramid Dy(L) architectures directed second-order template effects.

metal-templated (hydrazone) condensation also called subcomponent self-assembly of 4,6-dihydrazino-pyrimidine, -vanillin and dysprosium ions resulted in the formation of discrete hexa- or dodecanuclear metallosupramolecular Dy(L) or Dy(L) aggregates resulting from second-order template effects of the base and the lanthanide counterions used in these processes. XRD analysis revealed unique circular helical or tetragonal bipyramid architectures in which the bis(hydrazone) ligand L adopts different conformations and shows remarkable differences in its mode of metal coordination. While a molecule of trimethylamine acts as a secondary template that fills the void of the Dy(L) assembly, sodium ions take on this role for the formation of heterobimetallic Dy(L) by occupying vacant coordination sites, thus demonstrating that these processes can be steered in different directions upon subtle changes of reaction conditions.

Correction: Visible-light-mediated Minisci C-H alkylation of heteroarenes with unactivated alkyl halides using O as an oxidant.

[This corrects the article DOI: 10.1039/C8SC04892D.].

Higher benefit-risk ratio of COVID-19 vaccination in patients with schizophrenia and major depressive disorder versus patients with bipolar disorder when compared to controls.

Patients with major psychiatric disorders (MPD) that include schizophrenia (SCH), bipolar disorder (BP), and major depressive disorder (MDD) are at increased risk for coronavirus disease 2019 (COVID-19). However, the safety and efficacy of COVID-19 vaccines in MPD patients have not been fully evaluated. This study aimed to investigate adverse events (AEs)/side effects and efficacy of COVID-19 vaccines in MPD patients.