[Research progress on the application of polypeptide hydrogels in drug sustained/controlled release].

In recent years, peptide hydrogels have garnered significant attention in the biomedical field due to their excellent biocompatibility, biodegradability, and low cytotoxicity. They can mimic the microenvironment of the extracellular matrix, effectively encapsulate drugs, and achieve sustained or controlled drug release, thereby facilitate tissue regeneration. This article introduces the research progress in the application of peptide hydrogels for drug sustained/controlled release.

Valorization systems based on electrocatalytic nitrate/nitrite conversion for energy supply and valuable product synthesis.

The excessive accumulation of nitrate/nitrite (NO ) in surface and groundwater has severely disrupted the global nitrogen cycle and jeopardized public health. The electrochemical conversion of NO to ammonia (NH) not only holds promise for ecofriendly NO removal, but also provides a green alternative to the energy-intensive Haber-Bosch process for NH production. Recently, in addition to the electrocatalyst design explosion in this field, many innovative valorization systems based on NO -to-NH conversion have been developed for generating energy and expanding the range of value-added products.

Halogenation-induced C-N bond activation enables the synthesis of 1,2--aryl furanosides deaminative cyclization.

1,2--Aryl furanosides are prevalent in nature and exhibit significant biological activities. The 1,2- configuration is less favorable in terms of stereoelectronic and steric effects, making the synthesis of this type of skeleton highly challenging. Traditional methods for the synthesis of 1,2--aryl furanosides usually require complicated protection manipulations, resulting in lengthy synthetic routes and low overall efficiency.

Two new species and one new record of the genus Meyrick (Lepidoptera, Lecithoceridae) from China.

Two new species of the genus Meyrick, 1894 are described from China: and Additionally, Park, 2007 is newly recorded for China. Images of the adults and their genitalia are provided.

Tanshinone IIA, a component of Salvia miltiorrhiza Bunge, attenuated sepsis-induced liver injury via the SIRT1/Sestrin2/HO-1 signaling pathway.

Ethnopharmacological Relevance: As a traditional Chinese medicine, Salvia miltiorrhiza Bunge has been widely used to treat ischemic and inflammation-related diseases for more than 2000 years. S. miltiorrhiza Bunge has hepatoprotective effects, but the underlying mechanism is not fully understood.

Hydroselenation of olefins: elucidating the β-selenium effect.

We report a light-promoted hydroselenation of alkenes with high -Markovnikov selectivity. Blue light activates an aryl diselenide to generate a seleno radical with subsequent addition into an alkene to form a β-seleno carbon radical. Hydrogen atom transfer (HAT) from the selenol to the carbon radical generates the linear selenide with high selectivity in preference to the branched isomer.

Diversity of the Obligate Gut Bacteria Indicates Host-Symbiont Coevolution at the Population Level in the Plataspid Stinkbug .

is an obligate gut bacterium in stinkbugs that belong to Plataspidae family (Hemiptera: Heteroptera). It is vertically transmitted to newborn nymphs through capsules laid on eggs by maternal stinkbugs. Previous research has established a pattern of strict cospeciation between Plataspidae stinkbugs and .

Three-dimensional covalent organic framework-based artificial interphase layer endows lithium metal anodes with high stability.

To gain a deeper understanding and address the scientific challenges of lithium dendrite growth, a robust solid-state electrolyte interface (SEI) with good mechanical properties and rapid ion conduction is crucial for the advancement of lithium metal batteries. Artificial SEI layers based on organic polymers, such as covalent organic frameworks (COF), have garnered widespread attention due to their flexible structural design and tunable functionality. In this work, a COF with 3D spatial geometric symmetry and a fully covalent topology was synthesized and used as artificial SEI layers.

Effects of current density on Zn reversibility.

Aqueous zinc (Zn) batteries (AZBs) exhibit potential as viable candidates for stationary energy storage. Improvements in the plating/stripping efficiency and lifespan of Zn anodes at high applied current density () render AZBs attractive for rapid charge and discharge scenarios. However, the existing literature presents inconsistent experimental results and interpretations regarding the impact of on Zn reversibility.

Cyclodextrin supramolecular assembly confined luminescent materials.

The macrocyclic supramolecular assembly confinement effect not only induces or extends the fluorescence/phosphorescence luminescence behavior of guest molecules but has also been widely applied in the research fields of chemistry, biology, and materials. This review primarily describes recent advances in cyclodextrin (CD) supramolecular assembly confined luminescent materials. Taking advantage of their hydrophobic cavity, CDs and their derivatives effectively encapsulate guest molecules and special functional groups or further assemble and polymerize to restrict the motion of guest chromophores, inducing and enhancing the luminescence behavior and realizing intelligent stimulus-responsive luminescence depending on changes in temperature, light, redox reactions and solvent polarity, which are successfully applied in targeted cell imaging, sensing, information encryption, anti-counterfeiting and flexible electronic light-emitting devices.

Facilitating intrinsic delayed fluorescence of conjugated emitters by inter-chromophore interaction.

Delayed fluorescence (DF) is a unique emitting phenomenon of great interest for important applications in organic optoelectronics. In general, DF requires well-separated frontier orbitals, inherently corresponding to charge transfer (CT)-type emitters. However, facilitating intrinsic DF for local excited (LE)-type conjugated emitters remains very challenging.

The Zeb1-Cxcl1 axis impairs the antitumor immune response by inducing M2 macrophage polarization in breast cancer.

Zeb1, a key epithelial-mesenchymal transition (EMT) regulator, has recently been found to be involved in M2 macrophage polarization in the tumor immune microenvironment, thereby promoting tumor development. However, the underlying mechanism of Zeb1-induced M2 macrophage polarization remains largely unexplored. To identify the potential role of Zeb1 in remodeling the tumor immune microenvironment in breast cancer, we crossed the floxed Zeb1 allele homozygously into PyMT mice to generate PyMT; (MMTV-Cre;PyMT; ) mice.

Methane C(sp)-H bond activation by water microbubbles.

Microbubble-induced oxidation offers an effective approach for activating the C(sp)-H bond of methane under mild conditions, achieving a methane activation rate of up to 6.7% per hour under optimized parameters. In this study, microbubbles provided an extensive gas-liquid interface that promoted the formation of hydroxyl (OH˙) and hydrogen radicals (H˙), which facilitated the activation of methane, leading to the generation of methyl radicals (CH˙).

Solvation structure dependent ion transport and desolvation mechanism for fast-charging Li-ion batteries.

The solvation structures of Li in electrolytes play prominent roles in determining the fast-charging capabilities of lithium-ion batteries (LIBs), which are in urgent demand for smart electronic devices and electric vehicles. Nevertheless, a comprehensive understanding of how solvation structures affect ion transport through the electrolyte bulk and interfacial charge transfer reactions remains elusive. We report that the charge transfer reaction involving the desolvation process is the rate-determining step of the fast charging when ion conductivity reaches a certain value as determined by investigating electrolytes with eight conventional solvents (linear/cyclic carbonate/ether).

Green innovation and natural resource efficiency: The role of environmental regulations and resource endowment in Chinese cities.

Achieving natural resource utilization efficiency (NRUE) is a critical objective in addressing the pressing challenges of climate change and the risks associated with the finite availability of mineral resources. Enhancing NRUE can mitigate environmental impacts and support sustainable development for future generations. In this context, green innovation emerges as a pivotal driver of environmental sustainability and resource conservation.

Host-guest binding between cucurbit[8]uril and amphiphilic peptides achieved tunable supramolecular aggregates for cancer diagnosis.

The manipulation of biocompatible supramolecular nanostructures at subcellular and cellular levels has become one of the increasingly significant topics but remains a formidable challenge in chemical and biological science. In this work, a controllable supramolecular aggregate based on host-guest competitive binding is elaborately constructed using cucurbit[8]uril, methionine-containing amphiphilic peptide, and perylene diimide, displaying oxidation-driven macrocycle-confined fluorescence enhancement for cell imaging and morphological reconstruction for cancer cell death. The experimental results demonstrate that cucurbit[8]uril possesses a high binding affinity with the methionine peptide, while this value sharply decreases after the methionine residue is oxidized to sulfoxide or sulfone.

Unleashing the potential of Li-O batteries with electronic modulation and lattice strain in pre-lithiated electrocatalysts.

Efficient catalysts are indispensable for overcoming the sluggish reaction kinetics and high overpotentials inherent in Li-O batteries. However, the lack of precise control over catalyst structures at the atomic level and limited understanding of the underlying catalytic mechanisms pose significant challenges to advancing catalyst technology. In this study, we propose the concept of precisely controlled pre-lithiated electrocatalysts, drawing inspiration from lithium electrochemistry.

Sialylation-induced stabilization of dynamic glycoprotein conformations unveiled by time-aligned parallel unfolding and glycan release mass spectrometry.

Sialylation, a critical post-translational modification, regulates glycoprotein structure and function by tuning their molecular heterogeneity. However, characterizing its subtle and dynamic conformational effects at the intact glycoprotein level remains challenging. We introduce a glycoform-resolved unfolding approach based on a high-throughput ion mobility-mass spectrometry (IM-MS) platform.

Isomer engineering for deep understanding of aggregation-induced photothermal enhancement in conjugated systems.

Organic photothermal materials based on conjugated structures have significant potential applications in areas such as biomedical diagnosis, therapy, and energy conversion. Improving their photothermal conversion efficiency through molecular design is critical to promote their practical applications. Especially in similar structures, understanding how the position of heteroatoms affects the conversion efficiency is highly desirable.

Deboronative functionalization of alkylboron species a radical-transfer strategy.

With advances in organoboron chemistry, boron-centered functional groups have become increasingly attractive. In particular, alkylboron species are highly versatile reagents for organic synthesis, but the direct generation of alkyl radicals from commonly used, bench-stable boron species has not been thoroughly investigated. Herein, we describe a method for activating C-B bonds by nitrogen- or oxygen-radical transfer that is applicable to alkylboronic acids and esters and can be used for both Michael addition reactions and Minisci reactions to generate alkyl or arylated products.

Assessment of the application of a novel three-dimension printing individualized titanium mesh in alveolar bone augmentation: A retrospective study.

Objective: To assess the clinical and radiographic outcomes of alveolar ridge augmentation using a novel three-dimensional printed individualized titanium mesh (3D-PITM) for guided bone regeneration (GBR).

Materials And Methods: Preoperative cone-beam computed tomography (CBCT) was used to evaluate alveolar ridge defects, followed by augmentation with high-porosity 3D-PITM featuring circular and spindle-shaped pores. Postoperative CBCT scans were taken immediately and after 6 months of healing.

Recent progress in high-voltage P2-Na TMO materials and their future perspectives.

P2-type layered materials (Na TMO) have become attractive cathode electrodes owing to their high theoretical energy density and simple preparation. However, they still face severe phase transition and low conductivity. Current research on Na TMO is mostly focused on the modification of bulk materials, and the application performances have been infrequently addressed.