Synthesis of potent antifungal 3,4-dichloroisothiazole-based strobilurins with both direct fungicidal activity and systemic acquired resistance.

To continue our efforts to discover novel fungicide lead structures, a series of 3,4-dichloroisothiazole-based-strobilurin derivatives were synthesized and characterized. bioassay screening with 9 different plant pathogens suggested that the linker between 3,4-dichloroisothiazole and the pharmacophore played a critical role in fungicidal potency and scope. Among these, compound 2a with a -methoxy oxime ether as a linker was a better active compound.

Erratum: Angiopoietin-2 induces the neuronal differentiation of mouse embryonic NSCs via phosphatidylinositol 3 kinase-Akt pathway-mediated phosphorylation of mTOR.

[This corrects the article on p. 1895 in vol. 11, PMID: 30972213.

Angiopoietin-2 induces the neuronal differentiation of mouse embryonic NSCs via phosphatidylinositol 3 kinase-Akt pathway-mediated phosphorylation of mTOR.

The fate of neural stem cells (NSCs) is decided by numerous growth factors. Among these factors, the well-known angiogenic factor angiopoietin-2 (Ang-2) has been revealed to participate in neurogenesis separate from its role in angiogenesis. However, the effect of Ang-2 on the fate determination of mouse embryonic NSCs and the underlying mechanism remain unclear.