Monoallelic deleterious MUTYH mutations generate colorectal cancer: A case report.

Here we reported a particular case of MUTYH-associated polyposis (MAP) that had only one rare heterozygous variant, but some particular clinical manifestations contributed to occur in this male patient by only one defective MUTYH allele were worth of further investigation. We reported a case of MAP. It is about a 33-year-old man with chief complaints of hematochezia who had multiple polyps that were found in his colon via colonoscopy.

Covalent inorganic complexes enabled zinc blende to wurtzite phase changes in CdSe nanoplatelets.

Phase changes in colloidal semiconductor nanocrystals (NCs) are essential in material design and device applications. However, the transition pathways have yet to be sufficiently studied, and a better understanding of the underlying mechanisms is needed. In this work, a complete ligand-assisted phase transition from zinc blende (ZB) to wurtzite (WZ) is observed in CdSe nanoplatelets (NPLs).

Surface-enhanced Raman scattering sensing for detection and mapping of key cellular biomarkers.

Cellular biomarkers mainly contain proteins, nucleic acids, glycans and many small molecules including small biomolecule metabolites, reactive oxygen species and other cellular chemical entities. The detection and mapping of the key cellular biomarkers can effectively help us to understand important cellular mechanisms associated with physiological and pathological processes, which greatly promote the development of clinical diagnosis and disease treatment. Surface-enhanced Raman scattering (SERS) possesses high sensitivity and is free from the influence of strong self-fluorescence in living systems as well as the photobleaching of the dyes.

Enhancing organic cathodes of aqueous zinc-ion batteries utilizing steric hindrance and electron cloud equalization.

Polyaniline (PANI), with merits of high electronic conductivity and capacity, is a promising material for zinc (Zn)-ion batteries. However, its redox window in Zn batteries is often limited, mainly due to the oxidative degradation at high potentials-in which imine groups can be attacked by water molecules. Here, we introduce phytic acid, a kind of supermolecule acid radical ion, as a dopant and electrolyte additive.

A mixed-dimensional quasi-1D BiSeI nanowire-2D GaSe nanosheet p-n heterojunction for fast response optoelectronic devices.

Due to the unique combination configuration and the formation of a built-in electric field, mixed-dimensional heterojunctions present fruitful possibilities for improving the optoelectronic performances of low-dimensional optoelectronic devices. However, the response times of most photodetectors built from mixed-dimensional heterojunctions are within the millisecond range, limiting their applications in fast response optoelectronic devices. Herein, a mixed-dimensional BiSeI/GaSe van der Waals heterostructure is designed, which exhibits visible light detection ability and competitive photoresponsivity of 750 A W and specific detectivity of 2.

Cholesterol-rich dietary pattern during early pregnancy and genetic variations of cholesterol metabolism genes in predicting gestational diabetes mellitus: a nested case-control study.

Background: Higher dietary cholesterol intake during pregnancy increases risk of gestational diabetes mellitus (GDM). However, no studies have investigated interindividual variability in cholesterol metabolism and the association of genetics and diet on GDM.

Objective: ; To prospectively evaluate the joint association of cholesterol-rich dietary patterns and polymorphisms of genes coding for cholesterol metabolism pathway proteins with GDM.

Efficient All-Perovskite Tandem Solar Cells with Low-Optical-Loss Carbazolyl Interconnecting Layers.

Combining wide-band gap (WBG) and narrow-band gap (NBG) perovskites with interconnecting layers (ICLs) to construct monolithic all-perovskite tandem solar cell is an effective way to achieve high power conversion efficiency (PCE). However, optical losses from ICLs need to be further reduced to leverage the full potential of all-perovskite tandem solar cells. Here, metal oxide nanocrystal layers anchored with carbazolyl hole-selective-molecules (CHs), which exhibit much lower optical loss, is employed to replace poly(3,4-ethylenedioxythiophene) polystyrenesulfonate (PEDOT : PSS) as the hole transporting layers (HTLs) in lead-tin (Pb-Sn) perovskite sub-cells and ICLs in all-perovskite tandem solar cells.

Base-mediated C-B bond activation of benzylic boronate for the rapid construction of β-silyl/boryl functionalized 1,1-diarylalkanes from aromatic alkenes.

The effect of BuOK on the existing state of benzylic boronates in the solution phase has been investigated in detail by NMR analysis and DFT calculations. It was determined that simply using an excess of BuOK (2.0 equivalents) can result in the full deborylation of benzylic boronates to afford free benzyl potassium species.

Facile synthesis of gold nanocages with silver nanocubes templates dual metal effects enabled SERS imaging and catalytic reduction.

Silver (Ag) nanomaterials featuring a cubic shape particularly represent supreme class of advance nanomaterials. This work explored a new precursor and its effect on morphological features of silver (Ag) nanocubes (NCs) serving as sacrificial templates for facile synthesis of gold NCs. The AgNCs were initially prepared utilizing sodium thiosulphate (NaSO) as relatively stable S producing species along with a soft etchant source KCl.

Ultrafast C-C and C-N bond formation reactions in water microdroplets facilitated by the spontaneous generation of carbocations.

Carbocations are important electrophilic intermediates in organic chemistry, but their formation typically requires harsh conditions such as extremely low pH, elevated temperature, strong oxidants and/or expensive noble-metal catalysts. Herein, we report the spontaneous generation of highly reactive carbocations in water microdroplets by simply spraying a diarylmethanol aqueous solution. The formation of transient carbocations as well as their ultrafast in-droplet transformations through carbocation-involved C-C and C-N bond formation reactions are directly characterized by mass spectrometry.

Geometry guided crystallization of anisotropic DNA origami shapes.

Three-dimensional assembly based on DNA origami structures is an ideal method to precisely fabricate nano-scale materials. Additionally, applying an anisotropic assembly unit facilitates constructing complex materials with extraordinary structure. However, it still remains challenging to crystallize anisotropic DNA nano-structures using simple design, because the assembly of low-symmetry monomers often requires harsh auxiliary conditions and more complicated crystallization processes.

Host-guest system of a phosphorylated macrocycle assisting structure determination of oily molecules in single-crystal form.

X-ray crystallography is the most reliable method for structure elucidation and absolute configuration determination of organic molecules based on their single-crystal forms. However, many analytes are hard to crystallize because of their low melting points (an oily state at room temperature) or conformational flexibility. Here, we report the crystallization of a macrocycle, CTX[P(O)Ph] (host), which is a cyclotrixylohydroquinoylene (CTX) derivative, with 26 oily organic molecules (guests), which is applied for the structural determination of the guest with X-ray crystallography.

Macroscopic handedness inversion of terbium coordination polymers achieved by doping homochiral ligand analogues.

Inspired by natural biological systems, chiral or handedness inversion by altering external and internal conditions to influence intermolecular interactions is an attractive topic for regulating chiral self-assembled materials. For coordination polymers, the regulation of their helical handedness remains little reported compared to polymers and supramolecules. In this work, we choose the chiral ligands -pempH (pempH = (1-phenylethylamino)methylphosphonic acid) and -XpempH (X = F, Cl, Br) as the second ligand, which can introduce C-H⋯π and C-H⋯X interactions, doped into the reaction system of the Tb(-cyampH)·3HO (cyampH = (1-cyclohexylethylamino)methylphosphonic acid) coordination polymer, which itself can form a right-handed superhelix by van der Waals forces, and a series of superhelices -1H-, -2F-, -3Cl-, and -4Br- with different doping ratios were obtained, whose handedness is related to the second ligand and its doping ratio, indicating the decisive role of interchain interactions of different strengths in the helical handedness.

Study of the mechanisms of the phonon bottleneck effect in CdSe/CdS core/shell quantum dots and nanoplatelets and their application in hot carrier multi-junction solar cells.

The hot carrier multi-junction solar cell (HCMJSC) is one of the promising advanced conceptual solar cells with theoretical efficiency greater than 65%, consisting of a thin top junction with a wide bandgap and a thicker junction at the bottom with a medium bandgap for absorption of high and low energy photons. The wide bandgap CdSe/CdS low-dimensional systems ( quantum dots, QDs and nanoplatelets, NPLs) widely used in optoelectrical devices are expected to be an appropriate candidate for the top junction. However, the mechanisms underlying the carrier relaxation rate reduction (or phonon bottleneck effect, PBE) for HCMJSC in these material systems are not well understood so far.

[Effect of surface treatment on the three-point bend bonding strength between pure titanium fabricated by selective laser melting and porcelain].

Purpose: To evaluate the effect of surface treatment on bonding strength between pure titanium formed by selective laser melting and porcelain.

Methods: Pure titanium strips (64) and cobalt-chromium alloy strips (16) were laser machined to meet ISO 9693 standards. The pure titanium specimens were divided into 4 groups according to the sandblasting pressure and interlayer material.

[Effects and mechanisms of total flavones of Abelmoschus manihot in inhibiting podocyte necroptosis and renal fibrosis in diabetic kidney disease].

Previous studies have shown that high blood glucose-induced chronic microinflammation can cause inflammatory podocyte injury in patients with diabetic kidney disease(DKD). Therein, necroptosis is a new form of podocyte death that is closely associated with renal fibrosis(RF). To explore the effects and mechanisms in vivo of total flavones of Abelmoschus manihot(TFA), an extract from traditional Chinese herbal medicine Abelmoschus manihot for treating kidney diseases, on podocyte necroptosis and RF in DKD, and to further reveal its scientific connotation with multi-pathway and multi-target, the authors randomly divided all rats into four groups: a namely normal group, a model group, a TFA group and a rapamycin(RAP) group.

Mn(iii)-mediated C-P bond activation of diphosphines: toward a highly emissive phosphahelicene cation scaffold and modulated circularly polarized luminescence.

Transition metal mediated C-X (X = H, halogen) bond activation provides an impressive protocol for building polyaromatic hydrocarbons (PAHs) in C-C bond coupling and annulation; however, mimicking both the reaction model and Lewis acid mediator simultaneously in a hetero-PAH system for selective C-P bond cleavage faces unsolved challenges. At present, developing the C-P bond activation protocol of the phosphonic backbone using noble-metal complexes is a predominant passway for the construction of phosphine catalysts and P-center redox-dependent photoelectric semiconductors, but non-noble metal triggered methods are still elusive. Herein, we report Mn(iii)-mediated C-P bond activation and intramolecular cyclization of diphosphines by a redox-directed radical phosphonium process, generating phosphahelicene cations or phosphoniums with nice regioselectivity and substrate universality under mild conditions.

Phosphorylcholine-grafted graphene oxide loaded with irinotecan for potential oncology therapy.

2-Methacryloyloxyethyl phosphorylcholine (MPC) zwitterions were modified onto self-made graphene oxide (GO) through the atom transfer radical polymerization method. The chemical structures of the products were verified using Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, nuclear magnetic resonance spectroscopy (NMR), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), It was found that the modified GO (GO-PCn) is well dispersed in water with an average hydrodynamic diameter of about 170 nm. By utilizing the 2D planar structure of this modified graphene, the irinotecan@GO-PCn composite can be loaded with about 20% of irinotecan π-π stacking interaction and exhibit pH-sensitive drug release performance, releasing faster in the acidic environment.

Versatile synthesis of nano-icosapods cation exchange for effective photocatalytic conversion of biomass-relevant alcohols.

Branched metal chalcogenide nanostructures with well-defined composition and configuration are appealing photocatalysts for solar-driven organic transformations. However, precise design and controlled synthesis of such nanostructures still remain a great challenge. Herein, we report the construction of a variety of highly symmetrical metal sulfides and heterostructured icosapods based on them, in which twenty branches were radially grown in spatially ordered arrangement, with a high degree of structure homogeneity.

Individualised adjuvant immunotherapy with neoantigen-reactive T cells for gastric signet-ring cell carcinoma.

Objectives: The signet-ring cell carcinoma (SRCC) of the stomach is highly invasive. Patients with stage III gastric SRCC usually experience tumor recurrence within 2 years after radical surgery. Unfortunately, there is no effective treatment to postpone recurrence following adjuvant chemotherapy.

DE-UFormer: U-shaped dual encoder architectures for brain tumor segmentation.

. In brain tumor segmentation tasks, the convolutional neural network (CNN) or transformer is usually acted as the encoder since the encoder is necessary to be used. On one hand, the convolution operation of CNN has advantages of extracting local information although its performance of obtaining global expressions is bad.

INSM1 promotes breast carcinogenesis by regulating C-MYC.

Insulinoma-associated protein-1 (INSM1), which is highly expressed in various neuroendocrine tumors, functions as a zinc finger transcription factor capable of regulating the biological behavior of tumor cells. However, its specific role in breast cancer remains unclear. This study aims to investigate the role and mechanism of INSM1 in breast cancer.

Site-selective heat boosting electrochemiluminescence for single cell imaging.

visualization of local electrochemical reactions provides mechanical insights into the dynamic transport of interfacial charge and reactant/product. Electrochemiluminescence is a crossover technique that quantitatively determines Faraday current and mass transport in a straightforward manner. However, the sensitivity is hindered by the low collision efficiency of radicals and side reactions at high voltage.

Associations of Oral Contraceptive Use With Cardiovascular Disease and All-Cause Death: Evidence From the UK Biobank Cohort Study.

Background The associations of oral contraceptive (OC) use with cardiovascular disease (CVD) and all-cause death remains unclear. We aimed to determine the associations of OC use with incident CVD and all-cause death. Methods and Results This cohort study included 161 017 women who had no CVD at baseline and reported their OC use.