Study protocol: A national cross-sectional study on psychology and behavior investigation of Chinese residents in 2023.

Introduction: This study protocol specifies the primary research line and theoretical framework of the 2023 Survey of the Psychology and Behavior of the Chinese Population. It aims to establish a consistent database of Chinese residents' psychological and behavioral surveys through multi-center and large-sample cross-sectional surveys to provide robust data support for developing research in related fields. It will track the public's physical and psychological health more comprehensively and systematically.

A recyclable dynamic semiconducting polymer consisting of Pauli-paramagnetic diradicaloids promoted and stabilized by catechol-boron coordination.

Coordination between 5,5',6,6'-tetrahydroxyindigo (4OH-ID) and boron tribromide unexpectedly affords a novel dynamic covalent polymer, namely P(ID-O-B), consisting of alternating indigo and indigo diradicaloid units. The catechol-boron dynamic bond plays a vital role in promoting the diradicaloid formation and stabilizing the formed diradicaloid segments. The diradicaloid segment in the polymer has a triplet ground state and a thermally populated doublet state, which has been confirmed by the EPR study.

An artesunate-modified half-sandwich iridium(iii) complex inhibits colon cancer cell proliferation and metastasis through the STAT3 pathway.

Colon cancer is one of the most commonly diagnosed cancers and is recognized as the most aggressive tumor of the digestive system. Aberrant activation of signal transducer and activator of transcription 3 (STAT3) is associated with proliferation, metastasis and immunosuppression of the tumor cells. Here, to inhibit the STAT3 pathway and suppress metastasis in colon cancer cells, the half-sandwich iridium complex Ir-ART containing an artesunate-derived ligand was synthesized.

Interventional surgery shows efficacy for diabetic patients withperipheral vascular disease.

Objective: To analyze the effect of interventional surgery on treatment efficacy and inflammatory cytokine (ICK) levels in diabetic patients with peripheral vascular disease (PVD).

Methods: A total of 116 diabetic patients with PVD admitted to the Second Affiliated Hospital of Guangzhou Medical University from August 2020 to March 2022 were selected for this retrospective analysis. Patients were divided into two groups: 58 patients receiving conventional medication were assigned to the control group, while 58 patients receiving interventional surgery in addition to conventional medication were assigned to the research group.

Endoscopic maxillary sinus drainage combined with buccal fat pad flaps for repairing large oroantral fistulas in patients with odontogenic maxillary sinusitis.

Background: Oroantral fistula (OAF) is a pathological channel formed between the oral cavity and the maxillary sinus. A large size of OAF (≥5 mm) increases the risk of surgical failure, and an optimal surgical approach should be cautiously selected.

Objective: This study aims to characterize the application of nasal endoscopy and buccal fat pad (BFP) flaps to repair large OAFs in patients with odontogenic maxillary sinusitis (OMS).

A dual-locked cyclopeptide-siRNA conjugate for tumor-specific gene silencing.

Strategies allowing tumor-selective siRNA delivery while minimizing off-tumor gene silencing effects are highly demanded to advance cancer gene therapy, which however still remain challenging. We herein report a dual-locking bioconjugation approach to address this challenge. A dual-locked cyclopeptide-siRNA conjugate (DPRC) was designed to simultaneously endow siRNA with tumor-targeting properties and tumor-biomarker/visible-light dually controllable action.

Copper depletion-induced tumor cuproptosis.

Copper homeostasis is crucial for cells, especially for rapidly proliferating cancerous cells. Copper imbalance-induced cell death (, cuproptosis) has emerged as a new strategy for tumor therapy. While copper accumulation-induced cuproptosis has been extensively investigated and its underlying mechanism recently elaborated, copper depletion-induced cuproptosis remains largely unexplored.

Photoactivated hydride therapy under hypoxia beyond ROS.

As compared to oxidative phototherapy, studies on reactive reductive species-participating photodynamic therapy (PDT) are rare. Porphyrins are typical photosensitizers restricted by the oxygen level, but efficacy and selectivity are always incompatible in PDT. Herein, we report that phlorins are ideal hydride (H) donors and explore a water-soluble triphenylphosphonium-modified zinc-coordinated porphyrin (ZnPor) for photogeneration of zinc-cored phlorin (ZnPhl).

A high entropy metallic-high entropy nonmetallic community as a high performance electrocatalyst for the oxygen evolution reaction and oxygen reduction reaction.

The multi-element synergism in high-entropy materials (HEMs) provides great opportunities as multi-functional catalysts or for the promotion of tandem reactions. Herein, a strategy that utilizes a high entropy precursor is proposed to realize the formation of a unique high entropy metallic-high entropy non-metallic community (HEM-HENMC). Aminotriazole acts as a "bonding agent" for the high entropy precursor, and not only binds the five metals Cr, Mn, Fe, Co and Ni together, but also introduces nitrogen and carbon .

Regioselectivity switches between anthraquinone precursor fissions involved in bioactive xanthone biosynthesis.

Xanthone-based polyketides with complex molecular frameworks and potent bioactivities distribute and function in different biological kingdoms, yet their biosynthesis remains under-investigated. In particular, nothing is known regarding how to switch between the C-C (C-selective) and C-C bond (C-selective) cleavages of anthraquinone intermediates involved in biosynthesizing strikingly different frameworks of xanthones and their siblings. Enabled by our characterization of antiosteoporotic brunneoxanthones, a subfamily of polyketides from FB-2, we present herein the brunneoxanthone biosynthetic gene cluster and the C-selective cleavage of anthraquinone (chrysophanol) hydroquinone leading ultimately to the bioactive brunneoxanthones under the catalysis of BruN (an undescribed atypical non-heme iron dioxygenase) in collaboration with BruM as a new oxidoreductase that reduces the anthraquinone into its hydroquinone using NADPH as a cofactor.

Detecting Range Shrinking From Historical Amphibian Species Occurrences Under Influence of Human Impacts: A Case Study Using the Chinese Giant Salamander, .

Amphibian declines, driven by climate change (e.g., shifting temperatures, altered precipitation) and human activities like deforestation, agriculture, and urbanization, may lead to local extinctions.

An electrochemiluminescence device for visualized detection of lead in practical samples.

Lead (Pb) pollution poses a significant threat to human health due to its potential accumulation through the food chain. In response to this challenge, an array of electrochemiluminescence (ECL) devices has been developed for the accurate and visualized detection of trace Pb, achieving an ultra-low limit of detection (LOD) of 9.8 pg L.

Bovine serum albumin framed activatable NIR AIE photosensitizer for targeted tumor therapy.

Organic near-infrared (NIR) photosensitizers (PS) largely facilitate photodynamic therapy (PDT). To overcome aggregation induced quenching and diminishment of reactive oxygen species (ROS) generation capability of NIR-PS, aggregation-induced emission (AIE) effect groups have been introduced to generate NIR AIE photosensitizers. However, currently reported NIR AIE photosensitizers all take "always-on" activity that may cause systemic phototoxic side effects.

Efficient helical columnar emitters of chiral homoleptic Pt(ii) metallomesogens for circularly polarized electroluminescence.

Chiral organometallic Pt(ii) complexes have been demonstrated to be excellent circularly polarized luminescence (CPL) materials due to their rich phosphorescence and strong self-assembly characteristics. However, it remains a formidable task to simultaneously achieve high luminance () and electroluminescence dissymmetry factor ( ) values for circularly polarized electroluminescence (CP-EL) devices of Pt(ii) complex-based emitters. In this study, we carry out a straightforward and efficient protocol to construct highly CPL-active helical columnar () emitters by using chiral homoleptic triazolatoplatinum(ii) metallomesogens (/-HPt).

Developing functional hydrogels for treatment of oral diseases.

Oral disease is a severe healthcare challenge that diminishes people's quality of life. Functional hydrogels with suitable biodegradability, biocompatibility, and tunable mechanical properties have attracted remarkable interest and have been developed for treating oral diseases. In this review, we present up-to-date research on hydrogels for the management of dental caries, endodontics, periapical periodontitis, and periodontitis, depending on the progression of dental diseases.

A comparative study of the prognostic outcomes of periodontal soft tissue health in traditional restoration and micro-invasive restoration with the use of microscopy.

Objective: To compare the treatment efficacy of conventional restoration techniques versus micro-invasive restoration techniques utilizing a microscope in the restorative treatment for dental caries.

Methods: The clinical information of 84 patients who received restorative treatment for dental caries was retrospectively analyzed. Patients were divided into two groups according to the type of restoration they received.

Well-Being and Cardiovascular Health: Insights From the UK Biobank Study.

Background: Cardiovascular diseases (CVDs) are a leading global health concern. Emerging evidence suggests a potential protective role of well-being in reducing CVD risk.

Methods And Results: We conducted a cohort analysis using the UK Biobank data set, encompassing 121 317 participants.

Exclusive catalytic hydrogenation of nitrobenzene toward -aminophenol over atomically precise Au(SR) clusters.

Despite the advances in devising green methodologies for selective hydrogenation of nitrobenzene toward -aminophenol, it is still difficult to realize -aminophenol as the exclusive product in heterogeneous metal catalysis, as the excessive hydrogenation of nitrobenzene usually results in the aniline byproduct. Herein we report that a metal cluster containing 36 gold atoms capped by 24 thiolate ligands provides a unique pathway for nitrobenzene hydrogenation to achieve a -aminophenol selectivity of ∼100%. The gold cluster can efficiently suppress the over-hydrogenation of amino groups hydroxyl rearrangement with the aid of water and sequentially the proton transfer promoted by acid toward -aminophenol.

Impact of dental operative microscopes on precision in minimally invasive dental restoration procedures.

Objective: To evaluate the effect of dental operative microscopes on precision in minimally invasive dental restoration procedures.

Methods: This retrospective analysis included patients who underwent minimally invasive dental restoration procedure at Nanjing Stomatological Hospital from March 2018 to December 2019. Patients were categorized into two groups, an observation group treated with microscope-guided provisional restorations, and a control group treated using conventional methods.

Efficient circularly polarized multiple resonance thermally activated delayed fluorescence from B,N-embedded hetero[8]helicene enantiomers.

Helicene-based circularly polarized multiple resonance thermally activated delayed fluorescence (CP-MR-TADF) materials are promising for ultra-high-definition and 3D displays, but most of them encounter potential problems such as easy racemization during the thermal deposition process, low luminous efficiency, and low luminescence dissymmetry factor ( ), making the development of efficient circularly polarized organic light-emitting diodes (CP-OLEDs) a significant challenge. Here, we report a pair of CP-MR-TADF enantiomers with high-order B,N-embedded hetero[8]helicene, (/)-BN-TP-ICz, by fusing two MR chromophores, DtCzB and indolo[3,2,1-]carbazole (ICz). BN-TP-ICz exhibits green emission in toluene with a peak of 531 nm and a full-width at half-maximum (FWHM) of 36 nm.