[Advances in the pathology of digestive system diseases in China over the past ten years: retrospect and prospect].

The incidence of digestive system diseases is high. So digestive system pathology is widely concerned. In the past 10 years, Chinese pathologists insist on hard work and have made significant progress.

Comparative study on the inactivation and immunogenicity of Mycoplasma hyopneumoniae and Mycoplasma hyorhinis vaccines prepared using different inactivants.

The present study aimed to investigate the optimal inactivants and inactivation conditions for preparing inactivated vaccines of Mycoplasma hyopneumoniae and Mycoplasma hyorhinis. Mycoplasma inactivation was performed using formaldehyde, thimerosal, β-propiolactone (BPL), and binary ethylenimine (BEI) and compared. The results showed that M.

Carbon-supported Fe single atom nanozymes with long-lasting ROS generation and high NIR photothermal performance for synergistic cancer therapy.

Synergistic therapy combining photothermal therapy (PTT) and chemodynamic therapy (CDT) has proven to be a highly effective strategy for cancer treatment. However, PTT heavily relies on the accumulation of therapeutic agents at the tumor site. The peroxidase (POD) activity of common catalysts can be rapidly exhausted during the accumulation process, prior to laser intervention, thereby diminishing the synergistic enhancement effect of the combined therapy.

Post-procedural Plasma D-dimer Level May Predict Futile Recanalization in Stroke Patients with Endovascular Treatment.

Objective: High D-dimer levels may increase the likelihood of unfavorable clinical outcomes in patients with acute ischemic stroke. However, the impacts of serum D-dimer levels on outcomes of reperfusion treatment in patients with acute ischemic stroke have not been evaluated. This study aims to assess a possible relationship between serum D-dimer and functional outcomes in stroke patients with endovascular treatment (EVT).

Functional nanoplatform for modulating cellular forces to enhance antitumor immunity via mechanotransduction.

Immune cells are sensitive to the perception of mechanical stimuli in the tumor microenvironment. Changes in biophysical cues within tumor tissue can alter the force-sensing mechanisms experienced by cells. Mechanical stimuli within the extracellular matrix are transformed into biochemical signals through mechanotransduction.

Insight into selective removal of trace thallium (Tl(Ι)) by novel chitosan adsorbents encapsulating low-cost silicate mineral wastes.

Recently, thallium (Tl) contamination at trace levels has gained worldwide attention, particularly in the remote ore-smelting regions of China. To effectively eliminate the residual target Tl(I) ions, one of the best strategies is to develop novel adsorbents with high selectivity. In this study, we selected silicate mineral waste (SMW) and chitosan (CTS) to synthesize a low-cost composite adsorbent for the removal of trace Tl(I).

Attributes novel drug candidate: Constitutive GPCR signal bias mediated by purinergic receptors.

G protein-coupled receptors (GPCRs) can transmit signals via G protein-dependent or independent pathways due to the conformational changes of receptors and ligands, which is called biased signaling. This concept posits that ligands can selectively activate a specific signaling pathway after receptor activation, facilitating downstream signaling along a preferred pathway. Biased agonism enables the development of ligands that prioritize therapeutic signaling pathways while mitigating on-target undesired effects.

Underestimated Industrial Ammonia Emission in China Uncovered by Material Flow Analysis.

Ammonia (NH) is crucial in fine particulate matter (PM) formation, but past estimations on industrial NH emissions remain highly uncertain. In this study, the flow of NH within air pollution control devices (APCDs) were investigated basing on material flow analysis with in-situ measurements of NH concentrations at the inlets and outlets of each APCD. Then, by combing emission factors updated with recent in-situ measurements and provincial-level activity data from statistical yearbooks and associated reports, NH emissions from various industrial sources, as well as their spatial distribution across China in 2020, were evaluated.

Influence of precipitation and temperature variability on anthropogenic nutrient inputs in a river watershed: Implications for environmental management.

Since the Industrial Revolution, anthropogenic activities have substantially increased the input of nitrogen (N) and phosphorus (P) into river watersheds, exacerbated by uncertainties stemming from climate change. This study provided a detailed analysis of N and P inputs within the Dawen River Watershed in China from 2000 to 2021. The Net Anthropogenic Nitrogen Input (NANI) and Net Anthropogenic Phosphorus Input (NAPI) methods were used in study, which aimed to investigate how they respond to various climate change factors.

Evolutionary characteristics and influencing mechanisms of green development efficiency in Chinese urban agglomerations: Analysis of the Yangtze River Delta urban agglomeration.

Urban agglomerations are central to global economic growth and the shift towards green development, particularly in developing countries. This study examines regional comparisons and variations in green development mechanisms within urban agglomerations to better understand their spatiotemporal patterns. An input-output indicator system was developed, accounting for social benefits and carbon emissions.

Analysis of pathogen distribution, drug sensitivity and inflammatory indicators related to pelvic infection after hysterectomy.

Objective: To analyse the distribution of pathogens, risk factors and inflammatory indicators related to pelvic infection after hysterectomy.

Methods: Patients who underwent hysterectomy at Women's Hospital of Nanjing Medical University between January 2022 and January 2023 were recruited into this study. Vaginal secretions from patients with suspected postoperative pelvic infection were collected for pathogen cultivation, identification, and antimicrobial susceptibility analysis.

RMKD: Relaxed matching knowledge distillation for short-length SSVEP-based brain-computer interfaces.

Accurate decoding of electroencephalogram (EEG) signals in the shortest possible time is essential for the realization of a high-performance brain-computer interface (BCI) system based on the steady-state visual evoked potential (SSVEP). However, the degradation of decoding performance of short-length EEG signals is often unavoidable due to the reduced information, which hinders the development of BCI systems in real-world applications. In this paper, we propose a relaxed matching knowledge distillation (RMKD) method to transfer both feature-level and logit-level knowledge in a relaxed manner to improve the decoding performance of short-length EEG signals.

Multiple insights into differential Cd detoxification mechanisms in new germplasms of mung bean (Vigna radiata L.) and potential mitigation strategy.

Long-term cadmium (Cd) exposure inhibits plant growth and development, reduces crop yield and quality, and threatens food security. Exploring the Cd tolerance mechanisms and safe production of crops in Cd-contaminated environment has become a worldwide concern. In this study, mung bean (Vigna radiata L.

Evaluation of drug-drug interaction between rosuvastatin and tacrolimus and the risk of hepatic injury in rats.

Multimorbidity, therapeutic complexity, and polypharmacy, which greatly increases the risk of drug-drug interactions (DDIs) and adverse medical outcomes, have become important and growing challenges in clinical practice. Statins are frequently prescribed to manage post-transplant dyslipidemia and reduce overall cardiovascular risk in solid organ transplant recipients. This study aimed to determine whether rosuvastatin has significant DDIs with tacrolimus (the first-line immunosuppressant) and to evaluate the risk of hepatotoxicity associated with concomitant therapy.

Strategies and Challenges of Cytosolic Delivery of Proteins.

The cytosolic delivery of therapeutic proteins represents a promising strategy for addressing diseases caused by protein dysfunction. Despite significant advances, efficient delivery remains challenging due to barriers such as cell membrane impermeability, endosomal sequestration, and protein instability. This review summarizes recent progress in protein delivery systems, including physical, chemical, and biological approaches, with a particular focus on strategies that enhance endosomal escape and targeting specificity.

Synthesis of 1,4-Diketones from Esters Enabled by a Tetraborylethane Reagent.

A modular synthesis method for 1,4-diketones has been developed. Utilizing inexpensive carboxylic acid esters as carbonyl sources and tetraborylethane () as a nucleophilic reagent, a one-pot strategy for constructing two C-C bonds was established. Notably, this reaction proceeds without the involvement of transition metals and exhibits excellent functional group compatibility.

High-Performance Mechano-Sensitive Piezoelectric Nanogenerator from Post-Treated Nylon-11,11 Textiles for Energy Harvesting and Human Motion Monitoring.

Piezoelectric polymer textiles offer distinct advantages in the fabrication of wearable nanogenerators (NGs). One effective strategy to enhance the output capacity of NGs is to modulate the piezoelectric performance of the textiles. This paper focuses on further improving the piezoelectric properties of nylon-11,11 textiles through post-drawing and annealing treatments.

Correction: Razzaq et al. Development of Cephradine-Loaded Gelatin/Polyvinyl Alcohol Electrospun Nanofibers for Effective Diabetic Wound Healing: In-Vitro and In-Vivo Assessments. 2021, , 349.

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Pathophysiology and Treatment of Psoriasis: From Clinical Practice to Basic Research.

Psoriasis, a chronic inflammatory dermatosis, represents a significant clinical challenge due to its complex pathogenesis and the limitations of existing therapeutic strategies. Current psoriasis diagnoses are primarily clinician-dependent, with instrumental diagnostics serving as adjuncts. Ongoing research is progressively deciphering its molecular underpinnings; the future of psoriasis diagnostics may involve genetic and immunological profiling to pinpoint biomarkers, enabling more accurate and timely interventions.

Tenascin C-Guided Nanosystem for Precision Delivery of Obeticholic Acid in Liver Fibrosis Therapy.

Liver fibrosis, a hallmark of chronic liver diseases, is characterized by excessive extracellular matrix (ECM) deposition and scar tissue formation. Current antifibrotic nanomedicines face significant limitations, including poor penetration into fibrotic tissue, rapid clearance, and suboptimal therapeutic efficacy. The dense fibrotic ECM acts as a major physiological barrier, necessitating the development of a targeted delivery strategy to achieve effective therapeutic outcomes.

Innovative Solid Lipid Nanoparticle-Enriched Hydrogels for Enhanced Topical Delivery of L-Glutathione: A Novel Approach to Anti-Ageing.

Skin ageing, driven predominantly by oxidative stress from reactive oxygen species (ROS) induced by environmental factors like ultraviolet A (UVA) radiation, accounts for approximately 80% of extrinsic skin damage. L-glutathione (GSH), a potent antioxidant, holds promise in combating UVA-induced oxidative stress. However, its instability and limited penetration through the stratum corneum hinder its topical application.

VsMATE1-Mediated Citrate Efflux Is Involved in Al Resistance in Common Vetch ( L.).

Planting aluminum-tolerant legume green manure is a cost-effective and sustainable method to increase soil fertility as well as decrease Al toxicity in acidic soils. By analyzing the relative root elongation of seven legume green manure species, common vetch ( L.) was identified as an Al-resistant species.

Unveiling the Role of in Cotton Salt Stress Tolerance: A Comprehensive Genomic and Functional Analysis of Genes.

Proline, a critical osmoregulatory compound, is integral to various plant stress responses. The gene, which encodes the rate-limiting enzyme in proline biosynthesis, known as ∆1-pyrroline-5-carboxylate synthetase, is fundamental to these stress response pathways. While the functions of genes in plants have been extensively documented, their specific roles in cotton remain inadequately characterized.

Variations in the End-Use Quality of Whole Grain Flour Are Closely Related to the Metabolites in the Grains of Pigmented Wheat ( L.).

Whole grain flour is considered a part of a healthy diet, especially when produced with pigmented wheat (). However, the specific metabolic pathways and mechanisms by which these metabolites affect the end-use quality of pigmented wheat varieties still need to be better understood. This study examined the relationship between metabolite concentrations and the end-use quality of three wheat varieties: common wheat (CW, JM20), black wheat (BW, HJ1), and green wheat (GW, HZ148).

Analysis of the CHS Gene Family Reveals Its Functional Responses to Hormones, Salinity, and Drought Stress in Moso Bamboo ().

Chalcone synthase (CHS), the first key structural enzyme in the flavonoid biosynthesis pathway, plays a crucial role in regulating plant responses to abiotic stresses and hormone signaling. However, its molecular functions remain largely unknown in , which is one of the most economically and ecologically important bamboo species and the most widely distributed one in China. This study identified 17 genes in and classified them into seven subgroups, showing a closer evolutionary relationship to genes from rice.