27,279 results match your criteria: "Nanjing University of Sci. & Tech[Affiliation]"

Because of its dimensional characteristics, two-dimensional (2D) materials exhibit many special properties. The key to researching their features is to prepare high-quality larger-area monolayer 2D materials. Metal-assisted mechanical exfoliation method offers the possibility.

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In renewable power systems, the interaction between generators, power electronic devices, and the grid has led to frequent high-frequency oscillation (HFO) events. These events can result in significant generation losses and pose serious threats to system stability. Therefore, the rapid and accurate HFO parameter estimation is crucial for early warning and effective mitigation of HFO.

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Multiomic characterization, immunological and prognostic potential of SMAD3 in pan-cancer and validation in LIHC.

Sci Rep

January 2025

Jiangxi Key Laboratory of Molecular Medicine, Jiangxi Medical College, The Second Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, 330006, China.

SMAD3, a protein-coding gene, assumes a pivotal role within the transforming growth factor-beta (TGF-β) signaling pathway. Notably, aberrant SMAD3 expression has been linked to various malignancies. Nevertheless, an extensive examination of the comprehensive pan-cancer impact on SMAD3's diagnostic, prognostic, and immunological predictive utility has yet to be undertaken.

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The Cardiometabolic Index (CMI) is a well-recognized risk factor for a range of cardiovascular diseases and diabetes mellitus. However, the population-level characteristics of CMI and its potential association with mortality risk among individuals over 40 years of age have not been investigated. This study aims to assess the association between CMI and both all-cause and cardiovascular mortality among the middle-aged and elderly population.

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Tandospirone prevents anesthetic-induced respiratory depression through 5-HT receptor activation in rats.

Sci Rep

January 2025

Beijing Key Laboratory of Neuropsychopharmacology, State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Taiping Road 27, Beijing, 100850, China.

Respiratory depression is a side effect of anesthetics. Treatment with specific antagonists or respiratory stimulants can reverse respiratory depression caused by anesthetics; however, they also interfere with the sedative effects of anesthetics. Previous studies have suggested that tandospirone may ameliorate respiratory depression without affecting the sedative effects of anesthetics.

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Targeting the peculiarities of tumor tissue microenvironment different from normal tissue, such as lower pH and overexpression of hydrogen peroxide is the key to effective treatment. In this study, acid-responsive Z-scheme heterojunctions polyglycolated MoS/CoFeO (MoS = molybdenum disulfide, CoFeO = cobalt ferrite) was synthesized using a two-step hydrothermal method, designated as MSCO-PEG, guided by dual modes of photoacoustic imagine (PAI) and nuclear magnetic imaging (MRI). MSCO-PEG (PEG = polyethylene glycol) responded to the acidic environment of tumor tissues and overexpression of hydrogen peroxide to turn on multimodal synergistic treatment of tumor cells under near-infrared-II (NIR-II) illumination.

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A rare dominant allele determines seed coat color and improves seed oil content in .

Sci Adv

January 2025

College of Life Science and Technology, Key Laboratory of Molecular Biophysics of the Ministry of Education, Huazhong University of Science and Technology, Wuhan 430074, China.

Yellow seed coat color (SCC) is a valuable trait in , which is significantly correlated to high seed oil content (SOC) and low seed lignocellulose content (SLC). However, no dominant yellow SCC genes were identified in . In this study, a dominant yellow SCC N53-2 was verified, and then 58,981 eQTLs and 25 trans-eQTL hotspots were identified in a double haploid population derived from N53-2 and black SCC material Ken-C8.

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Background: spp. are protozoan parasites that infect the gastrointestinal tract of various animals, including goats, and can also contaminate water sources, posing a significant public health risk. Detecting oocysts in fecal and water samples is critical for understanding the epidemiology of cryptosporidiosis and implementing appropriate control measures.

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Background: Salmonella enterica serovar Enteritidis (S. Enteritidis) is a global foodborne pathogen that poses a significant threat to human health, with poultry being the primary reservoir host. Therefore, addressing S.

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Age-related hearing loss is the third most common health condition affecting elderly individuals. The relationship between lycopene in blood and sensorineural hearing loss in elderly adults has rarely been reported. This study aimed to elucidate the connection between serum lycopene levels and sensorineural hearing loss among elderly individuals.

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Two-dimensional (2D) hexagonal boron nitride (hBN) has garnered significant attention due to its exceptional thermal and chemical stability, excellent dielectric properties, and unique optical characteristics, making it widely used in deep ultraviolet (DUV) applications. However, the integration of hBN with plasmonic materials in the visible region (532 nm) has not been fully explored, particularly in terms of morphology regulation and size control of mono- and bimetallic nanoparticles (BMNPs) namely gold (Au), silver (Ag) and Au-Ag. A Schottky junction-based metal-semiconductor contact configuration is employed to achieve hot-carrier reflections on the metal side, enhancing the quantum efficiency of the photodetector.

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ALKBH5 acts a tumor-suppressive biomarker and is associated with immunotherapy response in hepatocellular carcinoma.

Sci Rep

January 2025

Phase I Clinical Trials Unit, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.

As immune-checkpoint inhibitors (ICIs) therapy has made great strides in hepatocellular carcinoma (HCC) treatment, improving patient response to this strategy has become the main focus of research. Accumulating evidence has shown that mA methylation plays a crucial role in the tumorigenesis and progression of HCC, while the precise impact of the mA demethylase ALKBH5 on the tumor immune microenvironment (TIME) of HCC remains poorly defined. The clinical significance of ALKBH5 and TIM3 were evaluated in human HCC tissues.

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Hydrological forecasting is of great significance to regional water resources management and reservoir operation. Climate change has increased the complexity and difficulty of hydrological forecasting. In this study, a hybrid explainable streamflow forecasting model based on CNN-LSTM-Attention was established for five typical river source regions in the eastern Qinghai-Tibet Plateau (EQTP).

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With the ongoing rise in the incidence of inflammatory bowel disease (IBD), its extraintestinal manifestations have garnered significant attention. IBD-related arthritis is notable for its insidious onset and unpredictability, presenting considerable challenges for clinical diagnosis and management. Factors such as gut microbiota, plasma proteins, inflammatory proteins, and biomarkers found in blood and urine may be closely associated with IBD-related arthritis.

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The control and industrial application of chaotic systems is a major obstacle limiting the diffusion of chaos theory. In this study, we proposed a novel, universally applicable methodology for constructing an offset boosting function for chaotic systems. By integrating this approach with traditional techniques, a four-dimensional chaotic system with two-dimensional offset boosting was developed and successfully implemented by a real chaotic circuit for manganese metal electrolysis, replacing conventional DC.

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It remains controversial as to which optimal cannulation strategy ought to be employed in surgery for type A aortic dissection (TAAD). The aim of this study was to make a comparison of the clinical outcomes between single and double arterial cannulation. From January 2018 to December 2022, 403 individuals with TAAD were recruited for the study and were divided into two groups based on the cannulation approach.

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In this paper, a robust fuzzy multi-objective framework is performed to optimize the dispersed and hybrid renewable photovoltaic-wind energy resources in a radial distribution network considering uncertainties of renewable generation and network demand. A novel multi-objective improved gradient-based optimizer (MOIGBO) enhanced with Rosenbrock's direct rotational technique to overcome premature convergence is proposed to determine the problem optimal decision variables. The deterministic optimization framework without uncertainty minimizes active energy loss, unmet customer energy, and renewable generation costs.

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Diabetic wounds are notoriously difficult to heal due to impaired cell repair mechanisms, reduced angiogenesis, and a heightened risk of infection. Fibroblasts play a vital role in wound healing by producing extracellular matrix (ECM) components and various growth factors, but their function is inhibited in diabetic wounds. Chitooligosaccharides (COS), intermediate products of chitosan degradation, have shown efficacy in promoting tissue repair, yet their role in diabetic wound healing remains underexplored.

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Structural dimensions of physical function and their associations with working memory in adults aged 60-74 years.

Sci Rep

January 2025

School of Physical Education, Shanghai University of Sport, 650 Qingyuanhuan Road, Yangpu District, Shanghai, China.

The association between physical function and working memory in older adults is moderated by structural dimensions of physical function, but it is unclear which structural dimensions of physical function are associated with working memory in healthy older adults. The purpose of this study was to construct the structural dimensions of physical function and assess their associations with working memory in adults aged 60-74 years to provide potential targets for earlier identification and interventions of physical function and working memory decline in older adults. To this end, data from 664 to 589 eligible older adults were used for factor analysis and structural equation modeling, respectively.

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This study aims to mine and analyze adverse events (AEs) of Vedolizumab based on the FAERS database to better understand its safety and potential risks in the real world. Data from the second quarter of 2014 to the third quarter of 2023 were collected, employing various signal mining methods such as Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), and Empirical Bayesian Geometric Mean (EBGM). The study gathered 14,753,012 reports of AEs, of which 46,726 were related to Vedolizumab.

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Enhancement of soy protein functionality by conjugation or complexation with polysaccharides or polyphenols: A review.

Compr Rev Food Sci Food Saf

January 2025

State Key Laboratory of Food Science and Resources, Jiangnan University, School of Food Science and Technology, Collaborative innovation center of food safety and quality control in Jiangsu Province, Jiangnan University, Wuxi, China.

Soy proteins have good nutritional quality and exhibit a range of useful functional attributes, making them a viable option for replacing animal proteins in the development of more sustainable and eco-friendly plant-based food products. Nevertheless, soy proteins are prone to denaturation and/or aggregation under conditions they encounter in some food and beverage products (including certain pH, ionic, and thermal conditions), which adversely impact their functional performance. This problem can often be overcome by covalently (conjugation) or noncovalently (complexation) linking the soy proteins to polysaccharides or polyphenols, thereby expanding their application scope.

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ECSIT-X4 is Required for Preventing Pressure Overload-Induced Cardiac Hypertrophy via Regulating Mitochondrial STAT3.

Adv Sci (Weinh)

January 2025

Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, 211166, China.

Mitochondrial dysfunction is a key factor in exacerbating pressure overload-induced cardiac hypertrophy and is linked to increased morbidity and mortality. ECSIT, a crucial adaptor for inflammation and mitochondrial function, has been reported to express multiple transcripts in various species and tissues, leading to distinct protein isoforms with diverse subcellular localizations and functions. However, whether an unknown ECSIT isoform exists in cardiac cells and its potential role in regulating mitochondrial function and pathological cardiac hypertrophy has remained unclear.

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Effects of a self-efficacy-centered self-management program on neurogenic bladder after spinal cord injury: A randomized controlled trial.

Jpn J Nurs Sci

January 2025

Center for Medical Ultrasound, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, Suzhou, China.

Purpose: The present research aimed to investigate the effects of a self-efficacy-centered self-management program on persons with neurogenic bladder (NGB) after spinal cord injury (SCI).

Design: A randomized controlled trial.

Materials And Methods: Eighty-two individuals with NGB after spinal cord injury (SCI) were randomized into either the control or intervention group.

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Liquid chromatography coupled with high resolution mass spectrometry reveals the inhibitory effects of Huangkuisiwu formula on biosynthesis of protein-binding uremic toxins in rats with chronic kidney disease.

J Chromatogr B Analyt Technol Biomed Life Sci

December 2024

Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China; Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:

Chronic kidney disease (CKD) is recognized as a common disorder worldwide. Protein-binding uremic toxins that cannot be efficiently removed by extracorporeal renal replacement therapies, such as indoxyl sulfate (IS) and p-cresyl sulfate (PCS), are associated with high risks of cardiovascular complications and high mortality in CKD population. This study aimed to explore the therapeutical effects of Huangkuisiwu formula (HKSWF) on CKD rats.

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The concept of a geometric series (GS) plays an important role in mathematics. However, it has been neglected in describing biological size series. Herein, we show that a GS describes the nonreproductive (perianth) parts of the flowers of four Magnoliaceae species and two Rosaceae species and the leaves of 60 Alangium chinense and 60 Shibataea chinensis shoots.

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