3 results match your criteria: "Nanjing University Nanjing 210023 P. R. China jjzhu@nju.edu.cn.[Affiliation]"
A "dual-key-and-lock" DNA nanodevice enables spatially controlled multimodal imaging and combined cancer therapy.
Chem Sci
July 2024
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University Nanjing 210023 P. R. China
Article Synopsis
- DNA-based theragnostic platforms face challenges like nonspecific interference and low effectiveness, prompting the development of a dual-key-and-lock (DKL) nanodevice for improved performance.
- The DKL-DND consists of a complex internal system that responds to specific conditions in cancer cells, enabling targeted imaging and combined therapies (gene, chemo, small molecules) to fight breast cancer.
- This innovative nanodevice shows strong potential for accurate tumor diagnosis and effective treatment by precisely controlling drug release and activation without premature action, making it a promising tool for multimodal imaging-guided therapies.
visualization of local electrochemical reactions provides mechanical insights into the dynamic transport of interfacial charge and reactant/product. Electrochemiluminescence is a crossover technique that quantitatively determines Faraday current and mass transport in a straightforward manner. However, the sensitivity is hindered by the low collision efficiency of radicals and side reactions at high voltage.
View Article and Find Full Text PDFA self-powered and drug-free diabetic wound healing patch breaking hyperglycemia and low HO limitations and precisely sterilizing driven by electricity.
Chem Sci
October 2022
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University Nanjing 210023 P. R. China
Accelerating diabetes-related chronic wound healing is a long-sought-after goal in diabetes management. However, therapeutic strategies based on antibiotics or catalysts still face great challenges to break the limitations of antimicrobial resistance, low HO and the blocking effect of bacterial biofilms on antibiotic/catalyst penetration. Herein, we reported a glucose biofuel cell-powered and drug-free antibacterial patch, which consisted of an MAF-7 protected glucose oxidase/horseradish peroxidase anode and a horseradish peroxidase cathode, for treating diabetic wounds.
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