2 results match your criteria: "Nanjing University Nanjing 210023 China hyan1965@nju.edu.cn.[Affiliation]"
Molecular engineering of AIE-active boron clustoluminogens for enhanced boron neutron capture therapy.
Chem Sci
March 2024
State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University Nanjing 210023 China
Article Synopsis
- A new boron delivery agent designed for boron neutron capture therapy (BNCT) integrates imaging capabilities and high boron content for effective cancer targeting.
- *The agent combines a carborane cluster for boron delivery, an erlotinib component for lung cancer cell targeting, and an AIE-active unit to enhance imaging.
- *Results show that this agent achieves high tumor selectivity and efficient tumor suppression while minimizing damage to surrounding tissue during neutron irradiation experiments.*
A switchable redox annulation of 2-nitroarylethanols affording -heterocycles: photoexcited nitro as a multifunctional handle.
Chem Sci
September 2022
State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University Nanjing 210023 China
The efficient transformation of nitroaromatics to functional molecules such as -heterocycles has been an attractive and significant topic in synthesis chemistry. Herein, a photoexcited nitro-induced strategy for switchable annulations of 2-nitroarylethanols was developed to construct -heterocycles including indoles, -hydroxyl oxindoles and -H oxindoles. The metal- and photocatalyst-free reaction proceeds through intramolecular redox C-N coupling of branched hydroxyalkyl and nitro units, which is initiated by a double hydrogen atom abstraction (-HAA) process.
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