Contact Dynamic Behaviors of Magnetic Hydrogel Soft Robots.

Magnetic hydrogel soft robots have shown great potential in various fields. However, their contact dynamic behaviors are complex, considering stick-slip motion at the contact interface, and lack accurate computational models to analyze them. This paper improves the numerical computational method for hydrogel materials with magneto-mechanical coupling effect, analyses the inchworm-like contact motion of the biomimetic bipedal magnetic hydrogel soft robot, and designs and optimizes the robot's structure.

Examining the Role of Psychological Symptoms and Safety Climate in Shaping Safety Behaviors Among Construction Workers.

Construction workers are often subjected to strenuous manual labor, poor working conditions, and prolonged separation from family, leading to psychological symptoms such as stress, depression, and anxiety. These psychological factors, combined with safety climate elements like risk perception and safety attitude, significantly influence workers' safety behaviors, including risk-taking, safety compliance, and safety participation. To address these issues, this study investigates the interplay between psychological symptoms, safety climate, and safety behaviors among construction workers in Mainland China.

The Moral Psychological Justification of Anger: An Exploration of Self-Respect and Recognition.

In the field of moral psychology, traditional perspectives often evaluate anger based on its consequences, either validating or condemning it for its perceived benefits or harms. This paper argues for a shift in focus from the outcomes of anger to its moral and psychological foundations. By integrating insights from psychological research, this study posits that the fundamental nature of anger is intrinsically linked to the quest for recognition.

Bionic Modeling Study on the Landing Mechanism of Flapping Wing Robot Based on the Thoracic Legs of Purple Stem Beetle, .

Flapping wing micro aerial vehicles (FWMAVs) are recognized for their significant potential in military and civilian applications, such as military reconnaissance, environmental monitoring, and disaster rescue. However, the lack of takeoff and landing capabilities, particularly in landing behavior, greatly limits their adaptability to the environment during tasks. In this paper, the purple stem beetle (), a natural flying insect, was chosen as the bionic research object.

A Bio-Inspired Visual Neural Model for Robustly and Steadily Detecting Motion Directions of Translating Objects Against Variable Contrast in the Figure-Ground and Noise Interference.

(1) Background: At present, the bio-inspired visual neural models have made significant achievements in detecting the motion direction of the translating object. Variable contrast in the figure-ground and environmental noise interference, however, have a strong influence on the existing model. The responses of the lobula plate tangential cell (LPTC) neurons of Drosophila are robust and stable in the face of variable contrast in the figure-ground and environmental noise interference, which provides an excellent paradigm for addressing these challenges.

Artificial Visual System for Stereo-Orientation Recognition Based on Hubel-Wiesel Model.

Stereo-orientation selectivity is a fundamental neural mechanism in the brain that plays a crucial role in perception. However, due to the recognition process of high-dimensional spatial information commonly occurring in high-order cortex, we still know little about the mechanisms underlying stereo-orientation selectivity and lack a modeling strategy. A classical explanation for the mechanism of two-dimensional orientation selectivity within the primary visual cortex is based on the Hubel-Wiesel model, a cascading neural connection structure.

A Numerical Study on the Crashworthiness of Corrugated Conical Tubes with Small Semi-Apical Angles and Their Influence Mechanism.

To develop a new type of biomimetic single-cell and multi-cell energy-absorbing box (tube) featuring conical tubes at the intersection of cell walls, it is necessary to address the issue of large bottom-space requirements in current conical energy-absorbing tubes with superior crashworthiness due to their large semi-apical angles. This study proposes adding corrugations to conical tubes with small semi-apical angles and modifying the bottom by replacing the last one or two inclined corrugations with vertical ones. Finite element simulation results show that, compared to conventional conical tubes, adding corrugations reduces the optimal semi-apical angle of conical tubes by 5°, with the optimal range being 5-10°.

Learning Dendritic-Neuron-Based Motion Detection for RGB Images: A Biomimetic Approach.

In this study, we designed a biomimetic artificial visual system (AVS) inspired by biological visual system that can process RGB images. Our approach begins by mimicking the photoreceptor cone cells to simulate the initial input processing followed by a learnable dendritic neuron model to replicate ganglion cells that integrate outputs from bipolar and horizontal cell simulations. To handle multi-channel integration, we utilize a nonlearnable dendritic neuron model to simulate the lateral geniculate nucleus (LGN), which consolidates outputs across color channels, an essential function in biological multi-channel processing.

Bionic Inner-Tapered Energy Absorption Tube Featuring Progressively Enhanced Fold Deformation Mode.

Slender tubes are in high demand owing to their lightweight and outstanding energy absorption. However, conventional slender tubes are prone to catastrophic failures such as Euler's buckling under axial load. Interestingly, growing bamboos overcome this similar dilemma via a unique tapered intine in the internodes, which endows them with excellent energy absorption.

The Differential Expressions and Associations of Intracellular and Extracellular GRP78/Bip with Disease Activity and Progression in Rheumatoid Arthritis.

GRP78/BiP, a stress-induced protein and autoantigen in rheumatoid arthritis (RA), exhibits different expressions in various biological fluids and tissues, including blood, synovial fluid (SF), and synovium, all of which are pertinent to the disease activity and progression of RA; however, there is a scarcity of data linking both intracellular and extracellular GRP78/Bip to disease activity and progression of RA. This study was undertaken to investigate the differential expression of GRP78/Bip in blood, SF, and synovium, and to determine their association with disease activity and progression of RA. Patients with RA, osteoarthritis (OA), and traumatic meniscal injury (TMI) without radiographic OA were consecutively recruited for the study.

SMARCA4/BRG1 deficiency induces a targetable dependence on oxidative phosphorylation in clear cell renal cell carcinoma.

The tumor suppressor gene SMARCA4, a critical component of the SWI/SNF chromatin remodeling complex, is frequently inactivated in various cancers, including clear cell renal cell carcinoma (ccRCC). Despite its significance, the role of SMARCA4 in ccRCC development and its potential therapeutic vulnerabilities have not been fully explored. Our research found that SMARCA4 deficiency was associated with poor prognosis and was observed in a subset of high-grade ccRCCs.

Correction: Chen . β-Sitosterol Enhances Lung Epithelial Cell Permeability by Suppressing the NF-κB Signaling Pathway. Discovery Medicine. 2023; 35(179): 946-955.

Correction of Discovery Medicine 2023, 35 (179) https://www.discovmed.com/EN/10.

Development and validation of a prediction model for estimating patency rates after treatment of haemodialysis access dysfunction.

Objective: This study aims to develop a risk assessment model for predicting haemodialysis access dysfunction and to construct a nomogram.

Method: The clinical data of patients with haemodialysis access dysfunction treated at our hospital from October 2020 to January 2024 were retrospectively analysed. The least absolute shrinkage and selection operator regression method was used to filter variables and select predictors, while Cox regression was applied to filter variables and construct a nomogram.

The Application of the Pyrazole Structure in the Structural Modification of Natural Products.

Most natural products in nature have broad but not exceedingly good biological activities. The pyrazole structure has been introduced into natural products due to its suitability for various synthetic methods and its broad pharmacological activities. This article provides a detailed introduction to the anti-inflammatory, antibacterial, antifungal, antiviral, and anti-Alzheimer disease activities of pyrazole-modified natural product derivatives, particularly their anti-tumor activity.

HMGB1 lactylation drives neutrophil extracellular trap formation in lactate-induced acute kidney injury.

Rationale: Acute kidney injury (AKI) is a clinical syndrome associated with a multitude of conditions. Although renal replacement therapy (RRT) remains the cornerstone of treatment for advanced AKI, its implementation can potentially pose risks and may not be readily accessible across all healthcare settings and regions. Elevated lactate levels are implicated in sepsis-induced AKI; however, it remains unclear whether increased lactate directly induces AKI or elucidates the underlying mechanisms.

Spatial distribution-based progression of spinal cord injury pathology: a key role for neuroimmune cells.

An external trauma, illness, or other pathological cause can harm the structure and function of the spinal cord, resulting in a significant neurological disorder known as spinal cord injury (SCI). In addition to impairing movement and sensory functions, spinal cord injury (SCI) triggers complex pathophysiological responses, with the spatial dynamics of immune cells playing a key role. The inflammatory response and subsequent healing processes following SCI are profoundly influenced by the spatial distribution and movement of immune cells.

Copper in the colorectal cancer microenvironment: pioneering a new era of cuproptosis-based therapy.

Copper, an essential trace element and biochemical cofactor in humans plays a critical role in maintaining health. Recent studies have identified a significant association between copper levels and the progression and metastasis of cancer. Copper is primarily absorbed in the intestinal tract, often leading to an imbalance of copper ions in the body.

Autophagic flux modulates tumor heterogeneity and lineage plasticity in SCLC.

Introduction: Small cell lung cancer (SCLC) is characterized by significant heterogeneity and plasticity, contributing to its aggressive progression and therapy resistance. Autophagy, a conserved cellular process, is implicated in many cancers, but its role in SCLC remains unclear.

Methods: Using a genetically engineered mouse model ( ; ; GFP-LC3-RFP-LC3△G), we tracked autophagic flux to investigate its effects on SCLC biology.

Surgical treatment of mammalian bites----experience in the management of facial wounds by dog and cat bite in China.

Mammalian bites to the face challenges not only related to wound healing but also to aesthetic outcomes. This study aims to summarize 7 years of experience in treating mammalian bite wounds and propose a surgical approach for managing these wounds. From July 2016 to August 2023, 185 cases were treated and retrospectively evaluated.

The Eurasian Magpie Preys on the Nests of Vinous-throated Parrotbills in Invasive Smooth Cordgrass.

Native animals worldwide are experiencing long-term coexistence with invasive plants, leading to diverse behavioral changes. Invasive plants may create new habitat structures that affect the distribution or behavior of prey, which in turn might attract predators to these novel habitats, thereby altering predator-prey dynamics within the ecosystem. However, this phenomenon is rarely reported.

Atacama Large Aperture Submillimeter Telescope (AtLAST) science: Probing the transient and time-variable sky.

The study of transient and variable events, including novae, active galactic nuclei, and black hole binaries, has historically been a fruitful path for elucidating the evolutionary mechanisms of our universe. The study of such events in the millimeter and submillimeter is, however, still in its infancy. Submillimeter observations probe a variety of materials, such as optically thick dust, which are hard to study in other wavelengths.

Assessment of heart rate deceleration capacity, heart rate deceleration runs, heart rate acceleration capacity, and lipoprotein-related phospholipase A2 as predictors in individuals with dementia.

Background: Autonomic dysfunction plays an essential role in dementia, however, it is not known whether electrocardiogram autonomic dysfunction-related indicators are associated with the severity of dementia. In this study, we attempted to investigate whether these indicators are correlated in patients with vascular dementia and Alzheimer's disease compared with normal health individuals. For this purpose, we measured and analyzed the predictive value of heart rate deceleration capacity (DC), heart rate deceleration runs (DRs), heart rate acceleration capacity (AC) along with the plasma levels of lipoprotein-associated phospholipase A2 (Lp-PLA2).

Structure-based identification of HNF4α agonists: Rosmarinic acid as a promising candidate for NAFLD treatment.

Unlabelled: The prevention and treatment of metabolic disorders, such as non-alcoholic fatty liver disease (NAFLD), have emerged as critical global health challenges. Current lipid-lowering pharmacotherapies are associated with side effects, including hepatotoxicity, rhabdomyolysis, and decreased erythrocyte counts, underscoring the urgent need for safer therapeutic alternatives. Hepatocyte nuclear factor 4α (HNF4α) has been identified as a pivotal regulator of lipid metabolism, making it an attractive target for drug development.