4 results match your criteria: "Nanjing Medical UniversityHuai'an 223300[Affiliation]"
MicroRNA-134-5p promotes high glucose-induced podocyte apoptosis by targeting bcl-2.
Am J Transl Res
March 2018
Department of Endocrinology, The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210000, China.
Podocyte apoptosis is a typical early feature of diabetic nephropathy (DN), with loss of nephrin integrity contributing to increased proteinuria in patients with DN. Emerging evidence shows that microRNAs (miRNAs) play vital roles in the pathogenesis of DN. Thus, we aimed to further elucidate the role of miRNAs in podocyte apoptosis in DN.
View Article and Find Full Text PDFVitamin D enhances resistance to aspergillus fumigatus in mice via inhibition of excessive autophagy.
Am J Transl Res
February 2018
Department of Medical Immunology, Medical School, Anhui University of Science and TechnologyHuai'nan 232001, Anhui, P. R. China.
Article Synopsis
- Vitamin D plays a crucial role in lung immune defense, and its deficiency is linked to increased susceptibility to respiratory infections.
- A study using rat models demonstrated that Vitamin D deficiency leads to higher mortality, increased fungal growth, and weight loss after infection compared to mice with sufficient Vitamin D levels.
- The research suggests that Vitamin D may affect lung defense mechanisms by delaying lysosome formation and altering autophagy and Treg cell levels, ultimately impairing pulmonary resistance.
The long noncoding RNA LINC00473, a target of microRNA 34a, promotes tumorigenesis by inhibiting ILF2 degradation in cervical cancer.
Am J Cancer Res
November 2017
Department of Obstetrics and Gynecology, Huai'an First People's Hospital, Nanjing Medical UniversityHuai'an 223300, Jiangsu, P. R. China.
Cervical cancer is one of the most common gynecological malignancies in women worldwide. The long non-coding RNA (lncRNA) LINC00473 is increased in some human cancer tissues and it plays important roles in tumorigenesis. However, neither the expression pattern nor the biological functions of LINC00473 have been elucidated in cervical cancer so far.
View Article and Find Full Text PDFFms related tyrosine kinase 1 (Flt1) functions as an oncogene and regulates glioblastoma cell metastasis by regulating sonic hedgehog signaling.
Am J Cancer Res
May 2017
Department of Neurosurgery, Huai'an First People's Hospital, Nanjing Medical UniversityHuai'an 223300, China.
Studies have shown that the abnormal expression of Fms related tyrosine kinase 1 (Flt1) is associated with multiple malignancies, yet its role in glioblastoma pathology remains to be elucidated. In this study, we investigated the role of Flt1 in regulating proliferation, migration and invasion of glioblastoma cells by establishing glioblastoma cell strains with constitutively silenced or elevated Flt1 expression. We demonstrate that ectopic expression of Flt1 promotes glioblastoma cells migration, invasion through cell scratching and Transwell assays.
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