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MicroRNAs in the prognosis of triple-negative breast cancer: A systematic review and meta-analysis.
Medicine (Baltimore)
June 2017
Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing Department of Clinical Laboratory, Yixing People's Hospital, Wuxi Department of Social Medicine and Health Education, School of Public Health, Nanjing Medical University The Innovation Center for Social Risk Governance in Health, Nanjing, China.
Article Synopsis
- Triple-negative breast cancer (TNBC) is aggressive and associated with poor survival, and the role of microRNAs (miRs) in its prognosis is still being studied.
- A meta-analysis of 21 studies (2510 subjects) identified six miRs linked to overall survival (OS) and disease-free survival (DFS) in TNBC patients.
- Key findings suggest that lower levels of miR-155 and higher levels of miR-21 are linked to worse OS, while elevated levels of miR-27a/b, miR-210, and miR-454 are also associated with shorter OS and DFS, indicating their potential as prognostic biomarkers.